Chemoresistance upregulation

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View the Evidence: Adverse Pharmacological Actions

Adrenaline induces chemoresistance in HT-29 colon adenocarcinoma cells.

Pubmed Data : Cancer Genet Cytogenet. 2009 Apr 15 ;190(2):81-7. PMID: 19380024
Article Published Date : Apr 15, 2009
Study Type : In Vitro Study
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Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Colon Cancer : CK(895) : AC(233)
Anti Therapeutic Actions : Stress : CK(30) : AC(9)
Problem Substances : Adrenaline : CK(1) : AC(1)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Chemoresistance upregulation : CK(1) : AC(1)

Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation.

Pubmed Data : J Cell Biochem. 2008 Sep 1 ;105(1):53-60. PMID: 18452159
Article Published Date : Sep 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Esophageal Cancer : CK(328) : AC(55), Squamous cell carcinoma : CK(79) : AC(36)
Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Vascular Endothelial Growth Factor A Inhibitor : CK(102) : AC(58)
Anti Therapeutic Actions : Stress : CK(30) : AC(9)
Problem Substances : Adrenaline : CK(1) : AC(1)
Adverse Pharmacological Actions : Chemoresistance upregulation : CK(1) : AC(1)

Psychological stress induces chemoresistance in breast cancer by upregulating mdr1.

Pubmed Data : Biochem Biophys Res Commun. 2005 Apr 15 ;329(3):888-97. PMID: 15752739
Article Published Date : Apr 15, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer : CK(2361) : AC(621), Cancers: Drug Resistant : CK(225) : AC(147), Cancers: Multi-Drug Resistant : CK(92) : AC(73)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)
Anti Therapeutic Actions : Stress : CK(30) : AC(9)
Problem Substances : Adrenaline : CK(1) : AC(1)
Adverse Pharmacological Actions : Chemoresistance upregulation : CK(1) : AC(1), Multidrug resistance 1 (p-glycoprotein 1) upregulation : CK(1) : AC(1)

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Stress Hormones Found To Make Cancer Resistant To Treatment
Written by Sayer Ji, Founder
There are many things that drive cancer. Poor diet, chemical and radiation exposures, and certain infections, figure prominently in the process. Stress, however, is a major contributing factor that is often ignored. New research, however, sheds light on how stress hormones make cancer cell resistant to multiple treatments.

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