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Quick Summary: Current access displays 2 out of 35 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles	Smart Search
Statin Drugs	15	6	Log in \| Sign up	Smart Search
Lovastatin	14	5	Log in \| Sign up	Smart Search

Quick Summary: Current access displays 2 out of 21 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles	Smart Search
Cornea Damage	10	1	Log in \| Sign up	Smart Search
Drug-Induced Toxicity	10	1	Log in \| Sign up	Smart Search

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View the Evidence: Adverse Pharmacological Actions

Pepper spray may result in damage to corneal nerve terminals with physical symptoms that last at least a week.

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Pubmed Data : Invest Ophthalmol Vis Sci. 2000 Jul ;41(8):2138-47. PMID: 10892855

Article Published Date : Jul 01, 2000

Study Type : Human Study

Additional Links

Diseases : Cornea Damage : CK(60) : AC(5)

Pharmacological Actions : Neuritogenic : CK(94) : AC(43)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

Anti Therapeutic Actions : Pepper Spraying : CK(85) : AC(11)

Problem Substances : Pepper Spray : CK(85) : AC(11)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35), Neurotoxic : CK(1042) : AC(170)

Statin drugs reduce coq10 levels which may result in mitochondrial dysfunction and cellular damage.

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Pubmed Data : J Clin Pharmacol. 1993 Mar;33(3):226-9. PMID: 8463436

Article Published Date : Mar 01, 1993

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity : CK(538) : AC(78), High Cholesterol : CK(1755) : AC(198), Myopathies : CK(241) : AC(51)

Additional Keywords : Drug-Nutrient Depletion : CK(64) : AC(7), Statin-Coq10 Depletion : CK(36) : AC(5)

Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(760) : AC(143), Statin Drugs : CK(3769) : AC(442)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

A two-generational reproductive study of zinc chloride in rats demonstrates it causes significant pathological changes in a wide range of tissues.

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Pubmed Data : J Environ Sci Health B. 2007 May;42(4):403-15. PMID: 17474020

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Problem Substances : Zinc Chloride : CK(21) : AC(8)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35), Genotoxic : CK(109) : AC(50), Teratogenic : CK(317) : AC(59)

Cupric sulfate and cadmium have genotoxic and cytotoxic effects.

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Pubmed Data : Food Chem Toxicol. 2005 Apr;43(4):569-74. PMID: 15721204

Article Published Date : Apr 01, 2005

Study Type : Animal Study

Additional Links

Problem Substances : Cadmium : CK(14) : AC(4), Cupric Sulfate : CK(49) : AC(16)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35), Genotoxic : CK(109) : AC(50)

Endocrine and toxic effects of Roundup, not just glyphosate, can be observed in mammals, and Roundup adjuvants enhance glyphosate bioavailability and/or bioaccumulation.

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Pubmed Data : Environ Health Perspect. 2005 Jun;113(6):716-20. PMID: 15929894

Article Published Date : Jun 01, 2005

Study Type : Animal Study

Additional Links

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Problem Substances : Glyphosate : CK(294) : AC(85)

Adverse Pharmacological Actions : Bioaccumulator : CK(102) : AC(23), Cytotoxic : CK(64) : AC(35), Endocrine Disruptor : CK(461) : AC(76)

Oral administration of titanium dioxide nanoparticles cause liver and heart injury, and wide distribution in the liver, spleen, kidneys and lung tissue.

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Pubmed Data : Toxicol Lett. 2007 Jan 30;168(2):176-85. Epub 2006 Dec 9. PMID: 17197136

Article Published Date : Jan 30, 2007

Study Type : Animal Study

Additional Links

Diseases : Cardiovascular Diseases : CK(5007) : AC(648), Chemical Exposure : CK(49) : AC(15), Liver Damage : CK(597) : AC(213)

Problem Substances : Titanium Dioxide : CK(41) : AC(17)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

Six food coloring agents have cytotoxic effects and amplify the toxicity of a chemical in a rat model of liver impairment.

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Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2000 Jun;46(3):130-6. PMID: 10955279

Article Published Date : Jun 01, 2000

Study Type : Animal Study

Additional Links

Diseases : Chemically-Induced Liver Damage : CK(453) : AC(175)

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Problem Substances : Brilliant Blue FCF : CK(4) : AC(3), Erythrosine : CK(2) : AC(1), FD&C Red #40 : CK(4) : AC(2), Food Colorings : CK(132) : AC(23), Ponceau 4R (New Coccine) : CK(2) : AC(1), Tartrazine (Yellow Food Dye) : CK(22) : AC(8)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35), Hepatotoxic : CK(266) : AC(73)

Study: Oral and intracheal toxicities of Roundup and its components.

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Pubmed Data : Vet Hum Toxicol. 1997 Jun;39(3):147-51. PMID: 9167243

Article Published Date : Jun 01, 1997

Study Type : Animal Study

Additional Links

Problem Substances : Glyphosate : CK(294) : AC(85), Polyoxyethylene amine : CK(12) : AC(7), Roundup (herbicide) : CK(280) : AC(78)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

Titanium dioxide nanoparticles cause acute toxicity, thrombosis, liver, lung and kidney damage when injected into mice.

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Pubmed Data : J Appl Toxicol. 2009 May;29(4):330-7. PMID: 19156710

Article Published Date : May 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Kidney Damage : CK(120) : AC(42), Lung Damage : CK(8) : AC(4)

Anti Therapeutic Actions : Nanotechnology : CK(60) : AC(12)

Problem Substances : Titanium Dioxide : CK(41) : AC(17)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

Triclosan bioconcentrates and exhibits toxicity to amphibian larvae.

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Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2010 Aug;152(2):232-40. Epub 2010 Apr 22. PMID: 20417311

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Problem Substances : Triclosan : CK(13) : AC(8)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

"Formulated glyphosate activates the DNA-response checkpoint of the cell cycle leading to the prevention of G2/M transition."

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Pubmed Data : Toxicol Sci. 2004 Dec ;82(2):436-42. Epub 2004 Sep 16. PMID: 15375296

Article Published Date : Dec 01, 2004

Study Type : In Vitro Study

Additional Links

Problem Substances : Glyphosate : CK(294) : AC(85)

Adverse Pharmacological Actions : Cell Cycle Inhibitor : CK(1) : AC(1), Cytotoxic : CK(64) : AC(35)

A commercial formulation of glyphosate inhibits proliferation and differentiation to adipocytes and induces programmed cell death in 3T3-L1 fibroblasts.

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Pubmed Data : Toxicol In Vitro. 2012 Apr 21. Epub 2012 Apr 21. PMID: 22546541

Article Published Date : Apr 21, 2012

Study Type : In Vitro Study

Additional Links

Diseases : Glyphosate Toxicity : CK(17) : AC(4)

Problem Substances : Glyphosate : CK(294) : AC(85)

Adverse Pharmacological Actions : Apoptotic : CK(8) : AC(7), Cytotoxic : CK(64) : AC(35)

A glyphosate-based pesticide impinges on transcription.

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Pubmed Data : Toxicol Appl Pharmacol. 2005 Feb 15 ;203(1):1-8. PMID: 15694458

Article Published Date : Feb 15, 2005

Study Type : In Vitro Study

Additional Links

Problem Substances : Glyphosate : CK(294) : AC(85), Polyoxyethylene amine : CK(12) : AC(7)

Adverse Pharmacological Actions : Cell Cycle Inhibitor : CK(1) : AC(1), Cytotoxic : CK(64) : AC(35)

Bisphosphonates exhibit cytotoxicity to the bone-building cells known as osteoblasts - Article 2.

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Pubmed Data : Calcif Tissue Int. 2008 Mar;82(3):191-201. Epub 2008 Feb 8. PMID: 18259679

Article Published Date : Mar 01, 2008

Study Type : In Vitro Study

Additional Links

Diseases : Osteoporosis : CK(1090) : AC(205)

Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Bisphosphonates : CK(510) : AC(61), Pamidronate (trade name Aredia) : CK(1) : AC(1)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

Bisphosphonates exhibit cytotoxicity to the bone-building cells known as osteoblasts.

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Pubmed Data : Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jul;106(1):5-13. Epub 2008 May 27. PMID: 18504149

Article Published Date : Jul 01, 2008

Study Type : In Vitro Study

Additional Links

Diseases : Osteoporosis : CK(1090) : AC(205)

Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Bisphosphonates : CK(510) : AC(61), Zoledronic Acid : CK(69) : AC(13)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

Borax exhibits cytotoxicity and genetic toxicity in human cells.

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Pubmed Data : J Occup Med Toxicol. 2009;4:27. Epub 2009 Oct 30. PMID: 19878537

Article Published Date : Jan 01, 2009

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage : CK(680) : AC(293)

Problem Substances : Borax (sodium borate) : CK(3) : AC(3)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35), Genotoxic : CK(109) : AC(50)

Both aluminium hydroxide and calcium phosphate exert local tissue irritating effects through damaging macrophages and increasing inflammation.

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Pubmed Data : Vaccine. 1997 Aug-Sep;15(12-13):1364-71. PMID: 9302746

Article Published Date : Aug 01, 1997

Study Type : In Vitro Study

Additional Links

Problem Substances : Aluminum Hydroxide : CK(56) : AC(14), Calcium Phosphate : CK(6) : AC(4)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35), Inflammatory : CK(135) : AC(37), Irritant : CK(49) : AC(9)

Bread wheat gliadin exhibits direct and signficant cytotoxicity.

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Pubmed Data : Scand J Clin Lab Invest. 2003 ;63(2):135-41. PMID: 12751695

Article Published Date : Jan 01, 2003

Study Type : In Vitro Study

Additional Links

Diseases : Gluten Intolerance : CK(236) : AC(33)

Problem Substances : Gliadin : CK(2244) : AC(99)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

DEET absorbs through the skin following topical application and may have significant toxicity.

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Pubmed Data : J Toxicol Environ Health. 1986;18(4):503-25. PMID: 3525852

Article Published Date : Jan 01, 1986

Study Type : Commentary

Additional Links

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35), Neurotoxic : CK(1042) : AC(170)

Despite the belief that immune-mediation is required for gliadin to damage to the body, gliadin appears to directly damage the cells exposed to it; i

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Pubmed Data : World J Gastroenterol. 2005 Oct 14 ;11(38):5973-7. PMID: 16273608

Article Published Date : Oct 14, 2005

Study Type : In Vitro Study

Additional Links

Diseases : Gastrointestinal Inflammation : CK(31) : AC(7), Oxidative Stress : CK(1867) : AC(710)

Problem Substances : Gliadin : CK(2244) : AC(99)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35), Oxidant : CK(114) : AC(37)

Ethylhexyl p-methoxycinnamate (EHMC), octyl p-dimethylaminobenzoate (PABA) and oxybenzone (OB) exhibit cytotoxicity and inhibit DNA synthesis.

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Pubmed Data : Photochem Photobiol. 1999 May;69(5):611-6. PMID: 10333769

Article Published Date : May 01, 1999

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage : CK(680) : AC(293)

Problem Substances : Ethylhexyl P-Methoxycinnamate (EHMC) : CK(1) : AC(1), Octyl P-Dimethylaminobenzoate (PABA) : CK(2) : AC(2), Oxybenzone : CK(30) : AC(10)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

Gliadin has a direct cytotoxic effect on the cytoskeleton and tight junctions of epithelial cells.

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Pubmed Data : World J Gastroenterol. 2005 Dec 28 ;11(48):7597-601. PMID: 16437684

Article Published Date : Dec 28, 2005

Study Type : In Vitro Study

Additional Links

Diseases : Gastrointestinal Inflammation : CK(31) : AC(7), Gluten Sensitivity : CK(2213) : AC(231), Intestinal Permeability : CK(263) : AC(56)

Problem Substances : Gliadin : CK(2244) : AC(99)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

Glyphosate pesticides are cytotoxic to human peripheral blood mononuclear cells.

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Pubmed Data : Biomedica. 2007 Dec;27(4):594-604. PMID: 18320126

Article Published Date : Dec 01, 2007

Study Type : In Vitro Study

Additional Links

Problem Substances : Glyphosate : CK(294) : AC(85), Roundup (herbicide) : CK(280) : AC(78)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35)

Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines at exceedingly small concentrations (.5 ppm to 10 ppm).

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Pubmed Data : Toxicology. 2009 Aug 21;262(3):184-91. Epub 2009 Jun 17. PMID: 19539684

Article Published Date : Aug 21, 2009

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage : CK(680) : AC(293)

Additional Keywords : Estrogen Receptor Beta : CK(24) : AC(11)

Problem Substances : Glyphosate : CK(294) : AC(85), Roundup (herbicide) : CK(280) : AC(78)

Adverse Pharmacological Actions : Cytotoxic : CK(64) : AC(35), Endocrine Disruptor : CK(461) : AC(76), Mutagenic : CK(22) : AC(11)

Glyphosate-based pesticides affect cell cycle regulation.

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Pubmed Data : Biol Cell. 2004 Apr ;96(3):245-9. PMID: 15182708

Article Published Date : Apr 01, 2004

Study Type : In Vitro Study

Additional Links

Problem Substances : Glyphosate : CK(294) : AC(85)

Adverse Pharmacological Actions : Cell Cycle Inhibitor : CK(1) : AC(1), Cytotoxic : CK(64) : AC(35)

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