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Article Count - 81
Cumulative Knowledge - 482

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Quick Summary: Current access displays 2 out of 68 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Statin Drugs	75	10	Log in \| Sign up
Organochlorine pesticides	52	6	Log in \| Sign up

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Statin-Induced Pathologies	77	12	Log in \| Sign up
Hypothyroidism	63	7	Log in \| Sign up

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View the Evidence: Adverse Pharmacological Actions

Chronic exposure to organochlorine compounds may contribute to type 2 diabetes and thyroid diseases.

Click here to read the entire abstract

Pubmed Data : Ann Ig. 2010 May-Jun;22(3):185-98. PMID: 20677670

Article Published Date : May 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8), Hyperthyroidism : CK(189) : AC(33), Hypothyroidism : CK(537) : AC(78), Thyroid Diseases : CK(182) : AC(23)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.

Click here to read the entire abstract

Pubmed Data : J Clin Invest. 2009 May;119(5):1322-34. Epub 2009 Apr 20. PMID: 19381015

Article Published Date : May 01, 2009

Study Type : Meta Analysis

Additional Links

Diseases : Abdominal Obesity (Midsection Fat) : CK(348) : AC(53), Dyslipidemias : CK(176) : AC(33), Fructose-Induced Toxicity : CK(138) : AC(49), Insulin Resistance : CK(1034) : AC(221), Obesity : CK(1869) : AC(275)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Thimerosal exposure is associated with increasing trends of premature puberty in 278,624 subjects from 1990-1996.

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Pubmed Data : Indian J Med Res. 2010 Apr;131:500-7. PMID: 20424300

Article Published Date : Apr 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Sexual Development: Dysfunctions and Abnormalities : CK(78) : AC(10)

Problem Substances : Thimerosal : CK(216) : AC(23)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Aluminium is found in human breast tissue and may be connected to breast cancer incidence.

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Pubmed Data : J Inorg Biochem. 2007 Sep ;101(9):1344-6. Epub 2007 Jun 12. PMID: 17629949

Article Published Date : Sep 01, 2007

Study Type : Human Study

Additional Links

Diseases : Aluminum Toxicity : CK(100) : AC(36), Breast Cancer : CK(2361) : AC(621)

Problem Substances : Aluminum : CK(154) : AC(41)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

An association exists between increased PCB and p,p'-DDE serum concentrations and the risk of endometriosis.

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Pubmed Data : Environ Health Perspect. 2009 Jul;117(7):1070-5. Epub 2009 Mar 31. PMID: 19654915

Article Published Date : Jul 01, 2009

Study Type : Human Study

Additional Links

Diseases : Endometriosis : CK(156) : AC(32)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

An epidemic of gynecomastia among haitian refugees was linked to phenothrin exposure.

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Pubmed Data : Endocr Pract. 2003 Sep-Oct;9(5):370-5. PMID: 14583418

Article Published Date : Sep 01, 2003

Study Type : Human Study

Additional Links

Diseases : Gynecomastia : CK(60) : AC(14)

Pharmacological Actions : Anti-Androgen : CK(58) : AC(15)

Problem Substances : Phenothrin : CK(10) : AC(1)

Adverse Pharmacological Actions : Anti-Androgenic : CK(20) : AC(2), Endocrine Disruptor : CK(478) : AC(81)

Breast enlargement is a common side effect of HIV treatment.

Click here to read the entire abstract

Pubmed Data : Clin Infect Dis. 2002 Nov 1;35(9):1113-9. Epub 2002 Oct 14. PMID: 12384846

Article Published Date : Nov 01, 2002

Study Type : Human Study

Additional Links

Diseases : HIV Drug-Induced Toxicity : CK(68) : AC(13)

Problem Substances : Antiretroviral Drugs : CK(42) : AC(6)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Cholesterol-lowering medications reduce DHEA-secretory responses and sperm motility.

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Pubmed Data : Metabolism. 1993 Sep ;42(9):1146-52. PMID: 8412767

Article Published Date : Sep 01, 1993

Study Type : Human Study

Additional Links

Diseases : DHEA: Low : CK(38) : AC(8), Sperm Quality: Low : CK(162) : AC(28), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349), Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Early-life soy exposure is associated with early onset menarche.

Click here to read the entire abstract

Pubmed Data : Paediatr Perinat Epidemiol. 2012 Mar ;26(2):163-75. Epub 2011 Dec 16. PMID: 22324503

Article Published Date : Mar 01, 2012

Study Type : Human Study

Additional Links

Substances : Soy : CK(1688) : AC(350)

Diseases : Hormone Imbalances : CK(31) : AC(4), Menarche: Early Onset : CK(10) : AC(1), Sexual Development: Dysfunctions and Abnormalities : CK(78) : AC(10)

Problem Substances : Soy : CK(56) : AC(8)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Excessive dietary fructose consumption appears to contribute to metabolic syndrome and non-alcholic fatty liver disease.

Click here to read the entire abstract

Pubmed Data : J Hepatol. 2008 Jun;48(6):993-9. Epub 2008 Mar 10. PMID: 18395287

Article Published Date : Jun 01, 2008

Study Type : Human Study

Additional Links

Diseases : Fatty Liver : CK(493) : AC(122), Insulin Resistance : CK(1034) : AC(221), Metabolic Syndrome X : CK(645) : AC(122)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Exposure to antibiotics during the first 6 months of life is associated with consistent increases in body mass from 10 to 38 months.

Click here to read the entire abstract

Pubmed Data : Int J Obes (Lond). 2012 Aug 21. Epub 2012 Aug 21. PMID: 22907693

Article Published Date : Aug 20, 2012

Study Type : Human Study

Additional Links

Diseases : Infant Chemical Exposures : CK(162) : AC(22), Obesity : CK(1869) : AC(275)

Problem Substances : Antibiotics : CK(180) : AC(19)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Obesogenic : CK(49) : AC(9)

Exposure to low-dose persistent organic pollutants appears to contribute to development of obesity, dyslipidemia, and insulin resistance.

Click here to read the entire abstract

Pubmed Data : PLoS One. 2011;6(1):e15977. Epub 2011 Jan 26. PMID: 21298090

Article Published Date : Jan 01, 2011

Study Type : Human Study

Additional Links

Diseases : Dyslipidemias : CK(176) : AC(33), Insulin Resistance : CK(1034) : AC(221), Obesity : CK(1869) : AC(275)

Problem Substances : Organochlorine pesticides : CK(260) : AC(30), Persistent organic pollutants (POPs) : CK(93) : AC(12), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

High-dose simvastatin reduces testosterone levels in men.

Click here to read the entire abstract

Pubmed Data : Metabolism. 2000 Sep ;49(9):1234-8. PMID: 11016911

Article Published Date : Sep 01, 2000

Study Type : Human Study

Additional Links

Diseases : Low Testosterone : CK(385) : AC(70)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

IGF1, IGF2 and IGFBP3 concentrations all decreased following atorvastatin therapy, which may be linked to its diabetogenic properties.

Click here to read the entire abstract

Pubmed Data : Eur J Endocrinol. 2013 Jan 18. Epub 2013 Jan 18. PMID: 23333902

Article Published Date : Jan 17, 2013

Study Type : Human Study

Additional Links

Diseases : IGF2 and IGFBP3: Low : CK(10) : AC(1), Insulin-Like Growth Factor (IGF): Low : CK(20) : AC(2)

Problem Substances : Atorvastatin : CK(491) : AC(90)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

In utero BPA exposure adversely affect male genital development.

Click here to read the entire abstract

Pubmed Data : Birth Defects Res A Clin Mol Teratol. 2011 Oct ;91(10):867-72. Epub 2011 Aug 26. PMID: 21987463

Article Published Date : Oct 01, 2011

Study Type : Human Study

Additional Links

Diseases : Prenatal Chemical Exposures : CK(322) : AC(86), Sexual Development: Dysfunctions and Abnormalities : CK(78) : AC(10)

Problem Substances : Bisphenol A : CK(217) : AC(54)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Levonorgestrel and ethinylestradiol oral contraceptive use results in lower levels of total and free testosterone in women.

Click here to read the entire abstract

Pubmed Data : Contraception. 1994 Dec;50(6):563-79. PMID: 7705098

Article Published Date : Dec 01, 1994

Study Type : Human Study

Additional Links

Diseases : Low Testosterone : CK(385) : AC(70), Testosterone: Too Low : CK(369) : AC(70)

Additional Keywords : Sex Hormone-Binding Globulin : CK(100) : AC(10)

Problem Substances : Ethinyl Estradiol : CK(38) : AC(7), Ethinyl Estradiol plus Lynestrenol : CK(34) : AC(5), Levonorgestrel : CK(45) : AC(7), Levonorgestrel/ethinyl estradiol : CK(41) : AC(5), Oral Contraceptives : CK(287) : AC(24)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Men treated for metastatic prostate cancer with anti-androgen therapy commonly experience andropause symptoms.

Click here to read the entire abstract

Pubmed Data : Cancer Nurs. 2011 May 9. Epub 2011 May 9. PMID: 21558849

Article Published Date : May 09, 2011

Study Type : Human Study

Additional Links

Diseases : Andropause Syndrome : CK(11) : AC(2), Gynecomastia : CK(60) : AC(14), Hot Flash : CK(203) : AC(19), Night Sweats : CK(10) : AC(1)

Problem Substances : Antiandrogen : CK(10) : AC(1)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Men treated with cholesterol-lowering drugs complain more frequently of erectile dysfunction.

Click here to read the entire abstract

Pubmed Data : J Clin Pharm Ther. 1996 Apr ;21(2):89-94. PMID: 8809645

Article Published Date : Apr 01, 1996

Study Type : Human Study

Additional Links

Diseases : Erectile Dysfunction : CK(510) : AC(41), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349), Fenofibrates : CK(133) : AC(19), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Mycoestrogens are found in 78.5% of Jersey girls and has been connected to endocrine disruption, e.g. delayed breast development.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Total Environ. 2011 Oct 3. Epub 2011 Oct 3. PMID: 21975003

Article Published Date : Oct 03, 2011

Study Type : Human Study

Additional Links

Diseases : Adolescent Diseases : CK(40) : AC(4), Breast Development: Delayed : CK(10) : AC(1), Sexual Development: Dysfunctions and Abnormalities : CK(78) : AC(10)

Problem Substances : Mycoestrogens : CK(10) : AC(1)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Organochlorine pesticides are a potent risk factor for peripheral arterial diseases in obese persons.

Click here to read the entire abstract

Pubmed Data : Atherosclerosis. 2011 May 10. Epub 2011 May 10. PMID: 21620405

Article Published Date : May 10, 2011

Study Type : Human Study

Additional Links

Diseases : Peripheral Arterial Disease : CK(260) : AC(26)

Problem Substances : Organochlorine compounds : CK(105) : AC(13)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Organophosphate pesticide exposure may adversely effect the thyroid.

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2010 Aug 5. Epub 2010 Aug 5. PMID: 20691716

Article Published Date : Aug 05, 2010

Study Type : Human Study

Additional Links

Diseases : Hypothyroidism : CK(537) : AC(78), Inappropriate TSH Secretion Syndrome : CK(20) : AC(2), Thyroid Diseases : CK(182) : AC(23)

Problem Substances : Organophosphates : CK(38) : AC(7), Pesticides : CK(699) : AC(70)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

PBDE exposure, at levels comparable with those of the general U.S. population, was associated with increased thyroglobulin antibodies and increased T(4) in adult males.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2008 Dec;116(12):1635-41. Epub 2008 Jul 24. PMID: 19079713

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Diseases : Autoimmune Diseases : CK(5317) : AC(779), Autoimmune Thyroiditis : CK(134) : AC(17), Thyroid Diseases : CK(182) : AC(23)

Problem Substances : Polybrominated diphenylethers (PBDEs) : CK(26) : AC(5), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Perchlorate exposure may significantly decrease thyroid iodine uptake.

Click here to read the entire abstract

Pubmed Data : Thyroid. 2000 Aug;10(8):659-63. PMID: 11014310

Article Published Date : Aug 01, 2000

Study Type : Human Study

Additional Links

Diseases : Hypothyroidism : CK(537) : AC(78)

Problem Substances : Perchlorate : CK(100) : AC(28)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Perchlorate exposure of .500 micro g/kg-day shows measurable effects on serum thyroid hormones.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2002 Sep;110(9):927-37. PMID: 12204829

Article Published Date : Sep 01, 2002

Study Type : Human Study

Additional Links

Diseases : Hypothyroidism : CK(537) : AC(78), Thyroid Diseases : CK(182) : AC(23)

Problem Substances : Perchlorate : CK(100) : AC(28)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Peripubertal aromatase inhibition in male rats has adverse long-term effects on bone strength and growth and induces prostatic hyperplasia.

Click here to read the entire abstract

Pubmed Data : J Endocrinol. 2010 Oct;207(1):27-34. Epub 2010 Jul 30. PMID: 20675302

Article Published Date : Oct 01, 2010

Study Type : Human Study

Additional Links

Diseases : Bone Diseases : CK(15) : AC(4), Children: Impaired Growth : CK(30) : AC(3), Drug-Induced Toxicity : CK(560) : AC(78), Prostatic Hyperplasia: Benign : CK(202) : AC(46)

Problem Substances : Aromatase Inhibitor Drugs : CK(360) : AC(21), Letrozole (trade name Femera) : CK(84) : AC(10)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

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