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Article Count - 81
Cumulative Knowledge - 482

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View the Evidence: Adverse Pharmacological Actions

Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction.

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Pubmed Data : Reprod Toxicol. 2002 Mar-Apr;16(2):117-22. PMID: 11955942

Article Published Date : Feb 28, 2002

Study Type : Animal Study

Additional Links

Diseases : Female Reproductive Development Abnormalities : CK(2) : AC(1)

Problem Substances : Bisphenol A : CK(217) : AC(54)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction.

Click here to read the entire abstract

Pubmed Data : Reprod Toxicol. 2002 Mar-Apr;16(2):117-22. PMID: 11955942

Article Published Date : Feb 28, 2002

Study Type : Animal Study

Additional Links

Diseases : Female Reproductive Development Abnormalities : CK(2) : AC(1)

Problem Substances : Bisphenol A : CK(217) : AC(54)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Maternal exposure to agrochemicals (such as glyphosate) during pregnancy induces a variety of functional abnormalities in the specific activity of the enzymes in the studied organs of the pregnant rats and their fetuses.

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Pubmed Data : Environ Res. 2001 Mar ;85(3):226-31. PMID: 11237511

Article Published Date : Mar 01, 2001

Study Type : Animal Study

Additional Links

Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Teratogenic : CK(304) : AC(59)

Monosodium glutamate is used to induce insulin resistance and obesity in an animal model.

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Pubmed Data : Lipids Health Dis. 2011;10:66. Epub 2011 Apr 28. PMID: 21526994

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Insulin Resistance : CK(1034) : AC(221), Obesity : CK(1849) : AC(275)

Problem Substances : Monosodium Glutamate (MSG) : CK(39) : AC(12)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Monosodium glutamate is used to induce metabolic syndrome in a rat model.

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Pubmed Data : Eur J Pharmacol. 2011 Jul 15;662(1-3):1-8. Epub 2011 May 1. PMID: 21549692

Article Published Date : Jul 15, 2011

Study Type : Animal Study

Additional Links

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hyperlipidemia : CK(1211) : AC(109), Metabolic Syndrome X : CK(645) : AC(122), Obesity : CK(1849) : AC(275)

Problem Substances : Monosodium Glutamate (MSG) : CK(39) : AC(12)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

MSG increases Obesity gene expression, leptin, insulin, LDL cholesterol, total lipids (TL), glucose and decreased leptin receptor-b gene expression.

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Pubmed Data : Acta Physiol Hung. 2011 Jun ;98(2):177-88. PMID: 21616776

Article Published Date : Jun 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Obesity : CK(1849) : AC(275), Overweight : CK(2176) : AC(342)

Problem Substances : Monosodium Glutamate (MSG) : CK(39) : AC(12)

Adverse Pharmacological Actions : Endocrine disruption: Leptin resistance : CK(6) : AC(3), Endocrine Disruptor : CK(478) : AC(81)

Perchlorate exposure induces hypothyroidism and affects thyroid-responsive genes in liver of quail chicks.

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Pubmed Data : Arch Environ Contam Toxicol. 2009 Oct;57(3):598-607. Epub 2009 Mar 24. PMID: 19308637

Article Published Date : Oct 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Hypothyroidism : CK(537) : AC(78)

Problem Substances : Perchlorate : CK(100) : AC(28)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Perchlorate induces hermaphroditism in threespine sticklebacks.

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Pubmed Data : Environ Toxicol Chem. 2006 Aug;25(8):2087-96. PMID: 16916028

Article Published Date : Aug 01, 2006

Study Type : Animal Study

Additional Links

Problem Substances : Perchlorate : CK(100) : AC(28)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Teratogenic : CK(304) : AC(59)

Prepubertal exposure to bisphenol A affects the onset of puberty, ovarian weights, and estrous cycle in female mice.

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Pubmed Data : Clin Exp Reprod Med. 2011 Jun ;38(2):75-81. Epub 2011 Jun 30. PMID: 22384422

Article Published Date : Jun 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Infertility: Female : CK(182) : AC(33), Sexual Development: Dysfunctions and Abnormalities : CK(78) : AC(10)

Problem Substances : Bisphenol A : CK(217) : AC(54)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Prolonged exposure to perchlorate disrupts thyroid and reproductive function in zebrafish.

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Pubmed Data : Toxicol Sci. 2007 Apr;96(2):246-54. Epub 2007 Jan 6. PMID: 17205975

Article Published Date : Apr 01, 2007

Study Type : Animal Study

Additional Links

Problem Substances : Perchlorate : CK(100) : AC(28)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Sodium fluoride during gestation and lactation affects male reproduction in adult rats by decreasing spermatogenesis and steroidogenesis.

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Pubmed Data : Naturwissenschaften. 2007 Jul;94(7):607-11. Epub 2007 Feb 22. PMID: 17318612

Article Published Date : Jul 01, 2007

Study Type : Animal Study

Additional Links

Diseases : Breastfeeding Concerns: Chemical Exposure : CK(91) : AC(15), Hormone Insufficency : CK(29) : AC(7), Infertility: Male : CK(209) : AC(52), Prenatal Chemical Exposures : CK(322) : AC(86)

Problem Substances : Sodium Fluoride : CK(88) : AC(26)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Tamoxifen impairs both longitudinal and cortical bone growth in young male rats.

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Pubmed Data : J Bone Miner Res. 2008 Aug;23(8):1267-77. PMID: 18348701

Article Published Date : Aug 01, 2008

Study Type : Animal Study

Additional Links

Diseases : Bone Diseases : CK(15) : AC(4)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

The early exposure to post-accidental doses of 137Cs induces the alteration of vitamin D metabolism, associated with a dysregulation of mineral homeostasis.

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Pubmed Data : Arch Toxicol. 2009 Apr;83(4):357-62. Epub 2008 Sep 17. PMID: 18797846

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Mineral Imbalances : CK(3) : AC(1), Prenatal Radiation Exposure : CK(16) : AC(5), Radiation-Induced Illness: Cesium-137 Exposure : CK(96) : AC(25), Vitamin D Metabolic Disorders : CK(2) : AC(1)

Problem Substances : Cesium-137 : CK(37) : AC(7)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

The fungicide Vinclozolin has been shown to have lasting transgenerational endocrine disrupting effects on male reproduction.

Click here to read the entire abstract

Pubmed Data : Semin Reprod Med. 2009 Sep;27(5):403-8. Epub 2009 Aug 26. PMID: 19711250

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Infertility: Male : CK(209) : AC(52), Prenatal Chemical Exposures : CK(322) : AC(86), Sexual Development: Dysfunctions and Abnormalities : CK(78) : AC(10)

Additional Keywords : Epigenetic Modification : CK(71) : AC(32), Transgenerational Epigenetic Modification : CK(6) : AC(3)

Problem Substances : Vinclozolin : CK(2) : AC(1)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

The glyphosate herbicide Roundup exhibits teratogenic potential in rats.

Click here to read the entire abstract

Pubmed Data : Toxicol Lett. 2003 Apr 30;142(1-2):45-52. PMID: 12765238

Article Published Date : Apr 30, 2003

Study Type : Animal Study

Additional Links

Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)

Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Teratogenic : CK(304) : AC(59)

The herbicide Roundup may cause disorder in the morphophysiology of the male genital system of animals.

Click here to read the entire abstract

Pubmed Data : Reprod Toxicol. 2007 Feb;23(2):182-91. Epub 2006 Nov 11. PMID: 17166697

Article Published Date : Feb 01, 2007

Study Type : Animal Study

Additional Links

Diseases : Endocrine Diseases : CK(13) : AC(3), Hormonal Disorders: Children : CK(14) : AC(3)

Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Tween 80 exposure in newborn rats results in disruption of female reproductive organs.

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 1993 Mar;31(3):183-90. PMID: 8473002

Article Published Date : Mar 01, 1993

Study Type : Animal Study

Additional Links

Problem Substances : Adjuvant : CK(18) : AC(6), Tween 80 : CK(2) : AC(1)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Endocrine Disruptor : CK(478) : AC(81)

Roundup exposure may adversely affect human reproduction and fetal development in case of contamination.

Click here to read the entire abstract

Pubmed Data : Arch Environ Contam Toxicol. 2007 Jul;53(1):126-33. Epub 2007 May 4. PMID: 17486286

Article Published Date : Jul 01, 2007

Study Type : In Vitro Study

Additional Links

Diseases : Endocrine Diseases : CK(13) : AC(3), Prenatal Chemical Exposures : CK(322) : AC(86)

Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)

Adverse Pharmacological Actions : Aromatase Disruptor : CK(1) : AC(1), Endocrine Disruptor : CK(478) : AC(81)

"Methyl mercury influences growth-related signaling in MCF-7 breast cancer cells."

Click here to read the entire abstract

Pubmed Data : Environ Toxicol. 2005 Feb ;20(1):32-44. PMID: 15712295

Article Published Date : Jan 31, 2005

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Problem Substances : Mercury : CK(96) : AC(11)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Endocrine Disruptor : CK(478) : AC(81), Estrogenic : CK(59) : AC(12)

Atorvastatin appears to increase the risk of deteriorating blood sugar control.

Click here to read the entire abstract

Pubmed Data : J Atheroscler Thromb. 2006 Jun ;13(3):123-9. PMID: 16835466

Article Published Date : Jun 01, 2006

Study Type : Review

Additional Links

Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Hyperglycemia : CK(2892) : AC(59)

Problem Substances : Atorvastatin : CK(491) : AC(90)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Benzophenone-3 (oxybenzone) and benzophenone-2 are structurally related to steroid receptor ligands and may act as endocrine disruptor.

Click here to read the entire abstract

Pubmed Data : Toxicology. 2004 Dec 1;205(1-2):123-30. PMID: 15458797

Article Published Date : Dec 01, 2004

Study Type : In Vitro Study

Additional Links

Additional Keywords : Estrogen Receptor Beta : CK(24) : AC(11)

Problem Substances : Benzophenones : CK(31) : AC(9), Oxybenzone : CK(30) : AC(10)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Estrogenic : CK(59) : AC(12)

Bisphenol A inhibits production of a wide range of steroid hormones.

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2010 Oct 18. Epub 2010 Oct 18. PMID: 20956811

Article Published Date : Oct 18, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Androgen Deficiency : CK(42) : AC(14), Estrogen Deficiency : CK(57) : AC(19), Hormone Insufficency : CK(29) : AC(7), Low DHEA : CK(38) : AC(7), Progesterone: Low : CK(34) : AC(15), Testosterone: Too Low : CK(369) : AC(70)

Problem Substances : Bisphenol A : CK(217) : AC(54)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

BPS, once considered a safe substitute for BPA, disrupts membrane-initiated E2-induced cell signaling, leading to altered cell proliferation, cell death,and PRL release.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2013 Mar ;121(3):352-8. Epub 2012 Dec 13. PMID: 23458715

Article Published Date : Feb 28, 2013

Study Type : In Vitro Study

Additional Links

Problem Substances : Bisphenol S : CK(21) : AC(9)

Adverse Pharmacological Actions : Cytotoxic : CK(73) : AC(35), Endocrine Disruptor : CK(478) : AC(81)

Central precocious puberty has been observed as a result of exposure to the mycotoxin Zearalenone .

Click here to read the entire abstract

Pubmed Data : Int J Clin Pract. 2012 Jan ;66(1):28-36. Epub 2011 Dec 6. PMID: 22145580

Article Published Date : Dec 31, 2011

Study Type : Review

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621), Puberty: Precocious : CK(1) : AC(1)

Problem Substances : Zearalenone (ZEA) : CK(19) : AC(9)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

excessive dietary fructose consumption may underlie the development of nonalcoholic fatty liver disease and the metabolic syndrome.

Click here to read the entire abstract

Pubmed Data : Nat Rev Gastroenterol Hepatol. 2010 May;7(5):251-64. Epub 2010 Apr 6. PMID: 20368739

Article Published Date : May 01, 2010

Study Type : Review

Additional Links

Diseases : Fatty Liver : CK(493) : AC(122), Fructose-Induced Toxicity : CK(138) : AC(49), Metabolic Syndrome X : CK(645) : AC(122), Oxidative Stress : CK(1945) : AC(710)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Related Blogs

Chemical Deception: Multiple Forms of Hormone-Disrupting Bisphenol Found In US Food Supply

Written by Sayer Ji, Founder

You know about the dangers of Bisphenol A (BPA), and hopefully Bisphenol S (BPS), but did you know that there are at least 8 toxic bisphenols in our food supply, with 75% of food samples from the US tested showing significant levels of these ubiquitous poisons?

Ignite Your Skin with Spray Tanning?

Written by Anne Gordon, RN

We all want a tan, and continuously are looking for a great product to theoretically protect our skin. People slather it on, spraying it, all over the neck, chest, and back. Who would have thought that putting it on could create a fire on the body? What??

Obesity Double Whammy: Sugary Sodas in BPA Cans and Plastic

Written by Case Adams, Naturopath

New research from New York State University has confirmed a link exists between Bisphenol A (BPA) and obesity. But there are a few caveats that reveal an even bigger link exposed in other research: The combination of sugary sodas in canned and plastic containers.

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