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Article Count - 61
Cumulative Knowledge - 146

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Quick Summary: Current access displays 2 out of 42 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Glyphosate	21	7	Log in \| Sign up
Tamoxifen	15	4	Log in \| Sign up

Quick Summary: Current access displays 2 out of 27 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
DNA damage	71	33	Log in \| Sign up
Endometrial Cancer	11	2	Log in \| Sign up

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View the Evidence: Adverse Pharmacological Actions

100% of male subjects tested had measurable urinary concentrations of parabens, and concentrations correlate with DNA damage in sperm.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2011 Feb ;119(2):252-7. Epub 2010 Sep 28. PMID: 20876036

Article Published Date : Feb 01, 2011

Study Type : Human Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Infertility: Male : CK(209) : AC(52)

Problem Substances : Parabens : CK(59) : AC(21)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Pre-diagnostic exposure to acrylamide may be related to mortality among breast cancer patients and that this may especially concern the most endocrine related type of breast cancer.

Click here to read the entire abstract

Pubmed Data : Toxicology. 2012 Jun 14 ;296(1-3):67-72. Epub 2012 Mar 20. PMID: 22465873

Article Published Date : Jun 13, 2012

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Prevention : CK(525) : AC(73)

Problem Substances : Acrylamide : CK(33) : AC(3)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Tamoxifen causes DNA adducs in the endometrium of women.

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2000 Aug;21(8):1461-7. PMID: 10910945

Article Published Date : Aug 01, 2000

Study Type : Human Study

Additional Links

Diseases : Endometrial Cancer : CK(269) : AC(45), Endometrial Neoplasms : CK(41) : AC(5)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Genotoxic : CK(146) : AC(61), Mutagenic : CK(22) : AC(11)

There is evidence that there is a genotoxic risk potential associated with exposure to glyphosate in areas where the herbicide is applied.

Click here to read the entire abstract

Pubmed Data : J Toxicol Environ Health A. 2009;72(15-16):986-97. PMID: 19672767

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Use of laptop computers connected to internet through Wi-Fi decreases human sperm motility and increases sperm DNA fragmentation.

Click here to read the entire abstract

Pubmed Data : Fertil Steril. 2011 Nov 22. Epub 2011 Nov 22. PMID: 22112647

Article Published Date : Nov 22, 2011

Study Type : Human Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Infertility: Male : CK(209) : AC(52), Sperm Count: Low : CK(235) : AC(4), Sperm Quality: Low : CK(162) : AC(28)

Anti Therapeutic Actions : Electromagnetic Fields : CK(103) : AC(14), Laptop Computer Use : CK(20) : AC(2), Wi-Fi Radiation : CK(10) : AC(1)

Problem Substances : Laptop computers : CK(20) : AC(2)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Atorvastatin exhibits immunotoxic and genotoxic properties - Article 2.

Click here to read the entire abstract

Pubmed Data : J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008 Jan ;43(1):78-85. PMID: 18161561

Article Published Date : Jan 01, 2008

Study Type : Human In Vitro

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Immune Disorders: Low Immune Function : CK(488) : AC(115), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Immunotoxic : CK(230) : AC(38)

Atorvastatin exhibits immunotoxic and genotoxic properties.

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2008 Aug 15 ;231(1):85-93. Epub 2008 Apr 8. PMID: 18485436

Article Published Date : Aug 15, 2008

Study Type : Human In Vitro

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Immune Disorders: Low Immune Function : CK(488) : AC(115), Oxidative Stress : CK(1945) : AC(710), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Immunotoxic : CK(230) : AC(38)

Cytogenetic damage and induction of pro-oxidant state has been observed in human lymphocytes exposed in vitro to glyphosate.

Click here to read the entire abstract

Pubmed Data : Environ Mol Mutagen. 1998 ;32(1):39-46. PMID: 9707097

Article Published Date : Jan 01, 1998

Study Type : Human In Vitro

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

The environmental metabolite of glyphosate, Aminomethylphosphonic acid, exhibits genotoxicity.

Click here to read the entire abstract

Pubmed Data : Ecotoxicol Environ Saf. 2009 Mar ;72(3):834-7. Epub 2008 Nov 14. PMID: 19013644

Article Published Date : Mar 01, 2009

Study Type : Human In Vitro

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Liver Cancer : CK(1641) : AC(266)

Problem Substances : Aminomethylphosphonic acid : CK(12) : AC(5), Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Clastogenic : CK(6) : AC(2), Genotoxic : CK(146) : AC(61)

A two-generational reproductive study of zinc chloride in rats demonstrates it causes significant pathological changes in a wide range of tissues.

Click here to read the entire abstract

Pubmed Data : J Environ Sci Health B. 2007 May;42(4):403-15. PMID: 17474020

Article Published Date : May 01, 2007

Study Type : Animal Study

Additional Links

Problem Substances : Zinc Chloride : CK(21) : AC(8)

Adverse Pharmacological Actions : Cytotoxic : CK(73) : AC(35), Genotoxic : CK(146) : AC(61), Teratogenic : CK(304) : AC(59)

Acid violet 7 and its biodegradation products induce chromosome aberrations, lipid peroxidation, and cholinesterase inhibition in mouse bone marrow.

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2010 Aug;17(7):1371-8. Epub 2010 Apr 6. PMID: 20369386

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Oxidative Stress : CK(1945) : AC(710)

Problem Substances : Acid Violet : CK(2) : AC(1)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Mutagenic : CK(22) : AC(11)

Both the general health condition and reproductive success of J. multidenatata (fish) could be seriously affected by Roundup.

Click here to read the entire abstract

Pubmed Data : Arch Environ Contam Toxicol. 2012 Jan ;62(1):107-17. Epub 2011 Jun 4. PMID: 21643816

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Problem Substances : Glyphosate formulations : CK(356) : AC(107), Roundup (herbicide) : CK(365) : AC(116)

Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Endocrine Disruptor : CK(478) : AC(81), Genotoxic : CK(146) : AC(61)

Commercial glyphosate herbicides exhibit genotoxicity in fish.

Click here to read the entire abstract

Pubmed Data : Mutagenesis. 2007 Jul;22(4):263-8. Epub 2007 Apr 10. PMID: 17426049

Article Published Date : Jul 01, 2007

Study Type : Animal Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Components of the original formulation of Roundup exhibit significant toxicity in five North American anurans (frogs; keystone species).

Click here to read the entire abstract

Pubmed Data : Ecotoxicol Environ Saf. 2012 Apr ;78:128-33. Epub 2011 Dec 3. PMID: 22137360

Article Published Date : Mar 31, 2012

Study Type : Animal Study

Additional Links

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(146) : AC(61)

Copper sulfate has genotoxic effects in chicks.

Click here to read the entire abstract

Pubmed Data : Mutat Res. 1996 Feb;367(2):57-63. PMID: 8643116

Article Published Date : Feb 01, 1996

Study Type : Animal Study

Additional Links

Problem Substances : Cupric Sulfate : CK(54) : AC(19)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Cupric sulfate and cadmium have genotoxic and cytotoxic effects.

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2005 Apr;43(4):569-74. PMID: 15721204

Article Published Date : Apr 01, 2005

Study Type : Animal Study

Additional Links

Problem Substances : Cadmium : CK(14) : AC(4), Cupric Sulfate : CK(54) : AC(19)

Adverse Pharmacological Actions : Cytotoxic : CK(73) : AC(35), Genotoxic : CK(146) : AC(61)

Cupric sulfate exhibits genotoxicity in freshwater fish.

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2001 Oct 18;497(1-2):19-27. PMID: 11525904

Article Published Date : Oct 18, 2001

Study Type : Animal Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Cupric Sulfate : CK(54) : AC(19)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Depleted uranium may cause genetic damage that is passed transgenerationally down to offspring.

Click here to read the entire abstract

Pubmed Data : Health Phys. 2010 Sep;99(3):371-9. PMID: 20699700

Article Published Date : Sep 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Cancers: Pediatric : CK(95) : AC(10), DNA damage : CK(711) : AC(293), Leukemia : CK(670) : AC(258), Radiation Induced Illness : CK(1018) : AC(249)

Problem Substances : Uranium: Depleted : CK(22) : AC(11)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Environmentally relevant concentrations of Roundup can pose a health risk for fish populations.

Click here to read the entire abstract

Pubmed Data : Mutagenesis. 2010 Sep ;25(5):523-30. Epub 2010 Jul 19. PMID: 20643706

Article Published Date : Aug 31, 2010

Study Type : Animal Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Lipid Peroxidation : CK(403) : AC(127)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(146) : AC(61)

Fish exposed to a glyphosate-based herbicide undergo DNA damage.

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2012 Mar 18 ;743(1-2):1-9. Epub 2012 Jan 14. PMID: 22266476

Article Published Date : Mar 17, 2012

Study Type : Animal Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(146) : AC(61)

Genotoxic effects of the herbicide Roundup(®) have been observed in the fish species Corydoras paleatus after short-term, environmentally low concentration exposure.

Click here to read the entire abstract

Pubmed Data : Environ Monit Assess. 2012 Jul 22. Epub 2012 Jul 22. PMID: 22821326

Article Published Date : Jul 21, 2012

Study Type : Animal Study, Environmental

Additional Links

Diseases : Glyphosate Toxicity : CK(22) : AC(12)

Problem Substances : Glyphosate : CK(365) : AC(116), Glyphosate formulations : CK(356) : AC(107), Roundup (herbicide) : CK(365) : AC(116)

Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(146) : AC(61)

Ibuprofen has a genotoxic affect in mouse bone marrow cells.

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2012 Jan 27. Epub 2012 Jan 27. PMID: 22283434

Article Published Date : Jan 27, 2012

Study Type : Animal Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Ibuprofen : CK(162) : AC(19)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Olive leaf extract protects against the genetic and oxidative damage by permethrin in vivo.

Click here to read the entire abstract

Pubmed Data : Cytotechnology. 2012 Jan 20. Epub 2012 Jan 20. PMID: 22262123

Article Published Date : Jan 20, 2012

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract : CK(132) : AC(26)

Diseases : DNA damage : CK(711) : AC(293), Oxidative Stress : CK(1945) : AC(710), Pesticide Toxicity: Permethrin : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Genoprotective : CK(116) : AC(48)

Problem Substances : Permethrin : CK(6) : AC(4)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Oxidant : CK(104) : AC(37)

Rosiglitazon is able to induce primary DNA damage in rats, with greater damage being detected in liver cells than lymphocytes.

Click here to read the entire abstract

Pubmed Data : Environ Mol Mutagen. 2006 Dec;47(9):718-24. PMID: 17078099

Article Published Date : Dec 01, 2006

Study Type : Animal Study

Additional Links

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), DNA damage : CK(711) : AC(293), Drug Toxicity : CK(4) : AC(2)

Problem Substances : Rosiglitazone (trade name Avandia) : CK(106) : AC(15)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Hepatotoxic : CK(283) : AC(80)

Roundup is able to induce a dose-dependent formation of DNA adducts in the kidneys and liver of mice.

Click here to read the entire abstract

Pubmed Data : Environ Mol Mutagen. 1998 ;31(1):55-9. PMID: 9464316

Article Published Date : Jan 01, 1998

Study Type : Animal Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Roundup (herbicide) : CK(365) : AC(116)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Health Guide: Cancer Research

Related Blogs

Big Pharma wants nano-scavengers in its drugs

Written by Rady Ananda

To clean up its drugs that are contaminated with genotoxic ingredients (which are also carcinogenic), Big Pharma may deploy lab-created, nanosized, polymer-based scavengers.

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