Hepatotoxic

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View the Evidence: Adverse Pharmacological Actions

Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations.

Pubmed Data : QJM. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21920996
Article Published Date : Sep 14, 2011
Study Type : Meta Analysis
Additional Links
Diseases : AST: Elevated : CK(26) : AC(4), Diabetes Insipidus : CK(35) : AC(5), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Elevated: ALT : CK(23) : AC(2), Elevated: Creatinine Kinase : CK(33) : AC(3), GGT : CK(73) : AC(10)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Aflatoxin exposure contributes to the development of primary liver cancer in patients with chronic hepatitis.

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2010 Jun 22 ;90(24):1665-9. PMID: 20979873
Article Published Date : Jun 22, 2010
Study Type : Human Study
Additional Links
Diseases : Hepatitis B : CK(226) : AC(39), Liver Cancer : CK(1641) : AC(266)
Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)
Problem Substances : Aflatoxin : CK(56) : AC(8)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Hepatotoxic : CK(283) : AC(80)

Atorvastatin-induced acute pancreatitis has been reported.

Pubmed Data : J Pharmacol Pharmacother. 2011 Jan ;2(1):40-2. PMID: 21701646
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Pancreatitis : CK(164) : AC(40), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Autoimmune hepatitis associated with atorvastatin use has been reported.

Pubmed Data : Eur J Gastroenterol Hepatol. 2003 Aug ;15(8):921-4. PMID: 12867804
Article Published Date : Aug 01, 2003
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis: Autoimmune : CK(41) : AC(8), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Celiac disease is associated with elevated transaminase levels in about one-third of newly diagnosed children with liver disease.

Pubmed Data : J Pediatr Gastroenterol Nutr. 2013 Feb 22. Epub 2013 Feb 22. PMID: 23434875
Article Published Date : Feb 21, 2013
Study Type : Human Study
Additional Links
Diseases : Cryptogenic Hypertransaminasemia : CK(10) : AC(1), Hepatitis: Autoimmune : CK(41) : AC(8)
Problem Substances : Gluten : CK(1755) : AC(144), Wheat : CK(2542) : AC(309)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Immunotoxic : CK(230) : AC(38)

Fatal liver necrosis due to allopurinol has been reported.

Pubmed Data : Acta Med Port. 1998 Dec;11(12):1141-4. PMID: 10192993
Article Published Date : Dec 01, 1998
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Liver Failure: Drug Induced : CK(23) : AC(3)
Problem Substances : Allopurinol : CK(37) : AC(5)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study.

Pubmed Data : CMAJ. 2012 Aug 13. Epub 2012 Aug 13. PMID: 22891208
Article Published Date : Aug 12, 2012
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175)
Problem Substances : Fluoroquinolone Antibiotic : CK(82) : AC(11)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Fluvastatin has been linked to adverse hepatic reactions.

Pubmed Data : Drug Saf. 2006 ;29(12):1163-72. PMID: 17147462
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Liver failure and damage are rare but severe unintended consequences of statin drug use.

Pubmed Data : J Hepatol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21889469
Article Published Date : Aug 31, 2011
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Liver Damage : CK(597) : AC(213), Liver Disease : CK(112) : AC(31), Liver Failure: Drug Induced : CK(23) : AC(3), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Severe liver toxicity requiring discontinuation occurs in 5% of simvastatin-treated patients and 4.5% of pravastatin-treated patients.

Pubmed Data : Minerva Gastroenterol Dietol. 1992 Jan-Mar;38(1):41-4. PMID: 1520752
Article Published Date : Jan 01, 1992
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Some 10% to 20% of heart transplant patients appear to suffer adverse side effects of initial statin therapy.

Pubmed Data : Transplant Proc. 2005 Nov ;37(9):4071-3. PMID: 16386629
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Muscle Soreness : CK(25) : AC(5), Myalgias : CK(105) : AC(14), Organ Transplantation: Heart : CK(34) : AC(5), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Atorvastatin : CK(491) : AC(90), Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Myotoxicity : CK(317) : AC(79)

Tamoxifen may induce fatty liver in patients with breast cancer.

Pubmed Data : AJR Am J Roentgenol. 2003 Jan;180(1):129-34. PMID: 12490491
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Diseases : Fatty Liver : CK(493) : AC(122)
Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)
Problem Substances : Tamoxifen : CK(319) : AC(39)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Tamoxifen treatment for breast cancer may result in fatty liver.

Pubmed Data : Oncol Rep. 2000 Nov-Dec;7(6):1299-304. PMID: 11032933
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Fatty Liver : CK(493) : AC(122)
Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Drug: Doxorubicin : CK(141) : AC(55), Drug: Tamoxifen : CK(380) : AC(57)
Problem Substances : Tamoxifen : CK(319) : AC(39)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Tamoxifen treatment in breast cancer may induce non-alcoholic fatty liver.

Pubmed Data : Intern Med. 2002 May;41(5):345-50. PMID: 12058881
Article Published Date : May 01, 2002
Study Type : Human Study
Additional Links
Diseases : Fatty Liver : CK(493) : AC(122)
Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)
Problem Substances : Tamoxifen : CK(319) : AC(39)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

A case of hepatitis caused by simvastatin has been reported.

Pubmed Data : Gastroenterol Clin Biol. 1991 ;15(1):94-5. PMID: 2010080
Article Published Date : Jan 01, 1991
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis : CK(64) : AC(23), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Lovastatin : CK(265) : AC(67), Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute cholestatic hepatitis associated with atorvastatin use has been reported.

Pubmed Data : Gastroenterol Hepatol. 2006 Jan ;29(1):21-4. PMID: 16393626
Article Published Date : Jan 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Cholestasis : CK(274) : AC(30), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute cholestatic hepatitis associated with pravastatin has been reported.

Pubmed Data : Am J Gastroenterol. 1999 May ;94(5):1388-90. PMID: 10235223
Article Published Date : May 01, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Cholestasis : CK(274) : AC(30), GGT : CK(73) : AC(10), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute cholestatic hepatitis induced by cerivastatin has been reported.

Pubmed Data : Med Clin (Barc). 2002 May 18 ;118(18):717. PMID: 12042141
Article Published Date : May 18, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Cholestasis : CK(274) : AC(30), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Cerivastatin : CK(10) : AC(4), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute cholestatic hepatitis induced by fenofibrate has been reported.

Pubmed Data : J Clin Pharm Ther. 2009 Oct;34(5):599-602. PMID: 19744016
Article Published Date : Oct 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Drug-Induced Toxicity : CK(560) : AC(78), Hepatitis : CK(64) : AC(23)
Problem Substances : Fenofibrates : CK(133) : AC(19)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute hepatic injury associated with varenicline in a patient with underlying liver disease has been reported.

Pubmed Data : Ann Pharmacother. 2009 Sep;43(9):1539-43. Epub 2009 Jul 28. PMID: 19638471
Article Published Date : Sep 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Alcoholic Liver Disease : CK(146) : AC(50), Hepatitis C : CK(401) : AC(62)
Problem Substances : Varenicline (trade name Chantix) : CK(39) : AC(5)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute hepatitis induced by lovastatin has been reported.

Pubmed Data : Dig Dis Sci. 1994 Sep ;39(9):2032-3. PMID: 8082513
Article Published Date : Sep 01, 1994
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), GGT : CK(73) : AC(10), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury.

Pubmed Data : Acta Gastroenterol Belg. 2008 Jul-Sep;71(3):318-20. PMID: 19198578
Article Published Date : Jul 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Bile Duct Injury : CK(6) : AC(2), Chemically-Induced Liver Damage : CK(475) : AC(175), Cholestasis : CK(274) : AC(30), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.

Pubmed Data : Arch Intern Med. 1999 Aug 9-23;159(15):1811-2. PMID: 10448788
Article Published Date : Aug 09, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Autoimmune hepatitis after treatment with fluvastatin has been reported.

Pubmed Data : Liver Int. 2007 May ;27(4):592. PMID: 17403199
Article Published Date : May 01, 2007
Study Type : Human: Case Report
Additional Links
Diseases : Hepatitis: Autoimmune : CK(41) : AC(8)
Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Immunotoxic : CK(230) : AC(38)

Autoimmune hepatitis triggered by statins has been reported.

Pubmed Data : J Clin Gastroenterol. 2006 Sep ;40(8):757-61. PMID: 16940892
Article Published Date : Sep 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Hepatitis: Autoimmune : CK(41) : AC(8)
Problem Substances : Atorvastatin : CK(491) : AC(90), Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Immunotoxic : CK(230) : AC(38)

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