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Article Count - 17
Cumulative Knowledge - 137

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Quick Summary: Current access displays 2 out of 14 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Cow Milk	40	4	Log in \| Sign up
Wheat	31	4	Log in \| Sign up

Quick Summary: Current access displays 2 out of 20 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Autoimmune Diseases	20	2	Log in \| Sign up
Gluten Sensitivity	20	2	Log in \| Sign up

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View the Evidence: Adverse Pharmacological Actions

"Whereas the development of anti-transglutaminase 2 IgA is linked with gastrointestinal disease, an anti-transglutaminase 6 IgG and IgA response is prevalent in gluten ataxia."

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Pubmed Data : Ann Neurol. 2008 Sep ;64(3):332-43. PMID: 18825674

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Diseases : Ataxia : CK(96) : AC(14), Gluten Ataxia : CK(10) : AC(1)

Problem Substances : Gliadin : CK(2509) : AC(110)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

An adverse immune reaction to wheat proteins is more commonly apparent (anti-tTG) in Sjögren's syndrome.

Click here to read the entire abstract

Pubmed Data : J Rheumatol. 2003 Dec ;30(12):2613-9. PMID: 14719202

Article Published Date : Dec 01, 2003

Study Type : Human Study

Additional Links

Diseases : Sjogren's Syndrome : CK(81) : AC(14)

Additional Keywords : anti-tissue transglutaminase antibodies

Problem Substances : Gluten : CK(1755) : AC(144), Wheat : CK(2542) : AC(309)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Antibodies to gliadin are more common in demyelinating diseases of the nervous sytem.

Click here to read the entire abstract

Pubmed Data : Eur J Neurol. 2013 Jan 7. Epub 2013 Jan 7. PMID: 23293933

Article Published Date : Jan 06, 2013

Study Type : Human Study

Additional Links

Diseases : Demyelinating Diseases : CK(1278) : AC(250), Neuromyelitis Optica : CK(4) : AC(2)

Problem Substances : Gliadin : CK(2509) : AC(110)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Approximately 1 in every 3 patients with atopic eczema are positive for anti-gliadin and/or anti-milk antibodies, indicating they may play a causitive role in the disease.

Click here to read the entire abstract

Pubmed Data : Clin Exp Dermatol. 1985 May;10(3):222-8. PMID: 4006283

Article Published Date : May 01, 1985

Study Type : Human Study

Additional Links

Diseases : Atopic Dermatitis : CK(667) : AC(80)

Problem Substances : Cow Milk : CK(368) : AC(46), Gliadin : CK(2509) : AC(110)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Children with atopic dermatitis commonly have specif IgE to common food allergens.

Click here to read the entire abstract

Pubmed Data : Iran J Immunol. 2012 Mar ;9(1):32-8. PMID: 22426165

Article Published Date : Mar 01, 2012

Study Type : Human Study

Additional Links

Diseases : Allergy: Cow's Milk : CK(92) : AC(18), Atopic Dermatitis: Infant & Childhood : CK(170) : AC(14), Food Allergies : CK(420) : AC(57), Food Allergies/Intolerances: Cereals/Grains : CK(11) : AC(2), Food Allergies: Wheat : CK(366) : AC(47), Nightshade Foods Intolerance : CK(10) : AC(1)

Problem Substances : Cow Milk : CK(368) : AC(46), Egg : CK(20) : AC(3), Nuts : CK(10) : AC(1), Peanut : CK(31) : AC(5), Potato : CK(43) : AC(11), Tomato : CK(10) : AC(1), Wheat : CK(2542) : AC(309)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Collagenous enterocolitis represents a diffuse manifestation of gluten sensitivity.

Click here to read the entire abstract

Pubmed Data : J Clin Gastroenterol. 1992 Jul ;15(1):45-51. PMID: 1500661

Article Published Date : Jul 01, 1992

Study Type : Human Study

Additional Links

Diseases : Colitis: Collagenous : CK(20) : AC(1), Gluten Sensitivity : CK(2477) : AC(270)

Problem Substances : Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17), Inflammatory : CK(150) : AC(37)

Elevated IgA rheumatoid factor may result from wheat consumption.

Click here to read the entire abstract

Pubmed Data : Acta Derm Venereol. 1995 Mar ;75(2):130-2. PMID: 7604641

Article Published Date : Mar 01, 1995

Study Type : Human Study

Additional Links

Diseases : Gluten Sensitivity : CK(2477) : AC(270), IgA rheumatoid factor: elevated : CK(20) : AC(2)

Problem Substances : Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Milk and bacterial proteins may produce neuron-specific antigens in children with autism.

Click here to read the entire abstract

Pubmed Data : J Neuroimmunol. 2002 Aug;129(1-2):168-77. PMID: 12161033

Article Published Date : Aug 01, 2002

Study Type : Human Study

Additional Links

Diseases : Autism Spectrum Disorders : CK(1140) : AC(108), Autoimmune Diseases : CK(5317) : AC(779), Brain Inflammation : CK(79) : AC(35)

Additional Keywords : Molecular Mimicry : CK(47) : AC(10)

Problem Substances : Butyrophilin : CK(20) : AC(2), Chlamydia Pneumoniae : CK(10) : AC(1), Cow Milk : CK(368) : AC(46), Streptococcal M Protein : CK(10) : AC(1)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17), Immunotoxic : CK(230) : AC(38), Neurotoxic : CK(1076) : AC(179)

Multiple myeloma patients exhibit humoral immunoreactivity to gliadin and to tissue transglutaminase, not unlike those with celiac disease.

Click here to read the entire abstract

Pubmed Data : BMC Immunol. 2008;9:22. Epub 2008 May 28. PMID: 18507842

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Diseases : Multiple Myeloma : CK(156) : AC(53), Wheat Intolerance : CK(2480) : AC(231)

Problem Substances : Gliadin : CK(2509) : AC(110), Wheat : CK(2542) : AC(309)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Patients with multiple myeloma have immunoreactivity to gliadin similar to those with celiac disease.

Click here to read the entire abstract

Pubmed Data : BMC Immunol. 2009;10:32. Epub 2009 May 31. PMID: 19480718

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : Celiac Disease : CK(1527) : AC(215), Multiple Myeloma : CK(156) : AC(53), Wheat Intolerance : CK(2480) : AC(231)

Additional Keywords : Differences in Immunoreactivity Within Different Wheat Cultivars : CK(11) : AC(2), Diseases that are Linked : CK(2122) : AC(270)

Problem Substances : Gliadin : CK(2509) : AC(110), Wheat : CK(2542) : AC(309)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Some patients with NHL possessed immunoreactivity to gliadin , indicating this protein may contribute to immune imbalance in the condition.

Click here to read the entire abstract

Pubmed Data : Int J Hematol. 2009 Sep ;90(2):212-6. Epub 2009 Jul 17. PMID: 19609644

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Non-Hodgkin Lymphoma : CK(525) : AC(67)

Problem Substances : Gliadin : CK(2509) : AC(110)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

There is an antibody cross-reactivity between myelin oligodendrocyte and milk protein in multiple sclerosis.

Click here to read the entire abstract

Pubmed Data : J Immunol. 2004 Jan 1;172(1):661-8. PMID: 14688379

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Diseases : Autoimmune Diseases : CK(5317) : AC(779), Milk Intolerance : CK(56) : AC(2), Multiple Sclerosis : CK(716) : AC(133)

Additional Keywords : Molecular Mimicry : CK(47) : AC(10)

Problem Substances : Butyrophilin : CK(20) : AC(2), Cow Milk : CK(368) : AC(46)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Peanut oil stimulates an immune response comparable to that of live measles vaccine.

Click here to read the entire abstract

Pubmed Data : Vaccine. 1996 Dec ;14(17-18):1703-6. PMID: 9032902

Article Published Date : Dec 01, 1996

Study Type : Human In Vitro

Additional Links

Diseases : Hypersensitivity : CK(64) : AC(15), Vaccine-induced Toxicity : CK(1130) : AC(163)

Problem Substances : Peanut Oil/ Lectin : CK(6) : AC(3), Vaccine Adjuvants : CK(383) : AC(77)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

At least 10% of sporadic cerebellar ataxia may be related to immune-mediated mechanisms which include gliadin intolerance.

Click here to read the entire abstract

Pubmed Data : Eur Neurol. 2009 ;62(6):356-61. Epub 2009 Sep 26. PMID: 19786780

Article Published Date : Jan 01, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Cerebellar Ataxia : CK(36) : AC(4)

Problem Substances : Gliadin : CK(2509) : AC(110)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Omega-5 gliadin anaphylaxis has been reported.

Click here to read the entire abstract

Pubmed Data : Eur Ann Allergy Clin Immunol. 2011 Jun ;43(3):92-4. PMID: 21789971

Article Published Date : Jun 01, 2011

Study Type : Human: Case Report

Additional Links

Diseases : Anaphylaxis: Exercise-Induced : CK(27) : AC(3)

Problem Substances : Gliadin : CK(2509) : AC(110)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Lovastatin alters the immunological balance towards a Th2 dominant state.

Click here to read the entire abstract

Pubmed Data : Neurosci Lett. 2002 Nov 29 ;333(3):167-70. PMID: 12429374

Article Published Date : Nov 29, 2002

Study Type : Animal Study

Additional Links

Diseases : Immune Dysregulation: TH1/TH2 imbalance : CK(146) : AC(36)

Pharmacological Actions : Interleukin-10 downregulation : CK(73) : AC(21), Interleukin-6 Downregulation : CK(470) : AC(135)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

"Wheat dependent exercise induced anaphylaxis possibly sensitized by the hydrolyzed wheat proteins in a facial cleansing soap"

Click here to read the entire abstract

Pubmed Data : J UOEH. 2012 Mar 1 ;34(1):85-9. PMID: 22428462

Article Published Date : Mar 01, 2012

Study Type : Review

Additional Links

Diseases : Anaphylaxis: Exercise-Induced : CK(27) : AC(3)

Problem Substances : Wheat : CK(2542) : AC(309)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Amino-functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages.

Click here to read the entire abstract

Pubmed Data : ACS Nano. 2011 Dec 27 ;5(12):9648-57. Epub 2011 Dec 8. PMID: 22111911

Article Published Date : Dec 27, 2011

Study Type : In Vitro Study

Additional Links

Diseases : Inflammation : CK(1077) : AC(363)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17), Inflammatory : CK(150) : AC(37)

Because anti-gliadin antibodies bind to neuronal synapsin I it is possible that molecular mimicry and antibody cross-reactivity are responsbile for neurological symptoms associated with gluten sensitivity.

Click here to read the entire abstract

Pubmed Data : J Immunol. 2007 May 15 ;178(10):6590-5. PMID: 17475890

Article Published Date : May 15, 2007

Study Type : Review

Additional Links

Diseases : Celiac Disease : CK(1527) : AC(215), Gluten Intolerance : CK(236) : AC(33), Gluten Sensitivity : CK(2477) : AC(270), Wheat Intolerance : CK(2480) : AC(231)

Additional Keywords : Anti-Gliadin Antibodies : CK(71) : AC(8)

Problem Substances : Gliadin : CK(2509) : AC(110)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Uptake of particulate vaccine adjuvants (e.g. nanoparticle polystyrene) by dendritic cells activates the NALP3 inflammasome.

Click here to read the entire abstract

Pubmed Data : Proc Natl Acad Sci U S A. 2009 Jan 20 ;106(3):870-5. Epub 2009 Jan 12. PMID: 19139407

Article Published Date : Jan 20, 2009

Study Type : In Vitro Study

Additional Links

Pharmacological Actions : Interleukin-1 beta downregulation : CK(177) : AC(70)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Polystyrene nanoparticles : CK(16) : AC(2), Vaccine Adjuvants : CK(383) : AC(77)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17), Immunotoxic : CK(230) : AC(38)

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