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Article Count - 37
Cumulative Knowledge - 162

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Quick Summary: Current access displays 2 out of 33 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Chemotherapy	20	1	Log in \| Sign up
Fructose	16	4	Log in \| Sign up

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Inflammation	38	7	Log in \| Sign up
Chemotherapy-Induced Toxicity	20	1	Log in \| Sign up

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View the Evidence: Adverse Pharmacological Actions

There are high rates of behavioral symptoms in breast cancer survivors, particularly those treated with chemotherapy

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Pubmed Data : J Clin Oncol. 2011 Aug 8. Epub 2011 Aug 8. PMID: 21825266

Article Published Date : Aug 08, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Depression : CK(674) : AC(88), Fatigue : CK(194) : AC(30), Inflammation : CK(1077) : AC(363), Insomnia : CK(471) : AC(56)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Problem Substances : Chemotherapy : CK(348) : AC(44)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Tumor necrosis factorα (TNFα) up-regulation : CK(42) : AC(4)

Chronic ingestion of acrylamide-containing products (potato chips) induces a proinflammatory state, a risk factor for progression of atherosclerosis.

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2009 Mar ;89(3):773-7. Epub 2009 Jan 21. PMID: 19158207

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Diseases : C-Reactive Protein : CK(819) : AC(74), Cholesterol: Oxidation : CK(457) : AC(98), Lipid Peroxidation : CK(403) : AC(127)

Pharmacological Actions : Interleukin-6 Downregulation : CK(470) : AC(135)

Problem Substances : Acrylamide : CK(33) : AC(3), Potato : CK(43) : AC(11), Potato Chips : CK(10) : AC(1)

Adverse Pharmacological Actions : Atherogenic : CK(21) : AC(3), Inflammatory : CK(150) : AC(37)

Collagenous enterocolitis represents a diffuse manifestation of gluten sensitivity.

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Pubmed Data : J Clin Gastroenterol. 1992 Jul ;15(1):45-51. PMID: 1500661

Article Published Date : Jul 01, 1992

Study Type : Human Study

Additional Links

Diseases : Colitis: Collagenous : CK(20) : AC(1), Gluten Sensitivity : CK(2477) : AC(270)

Problem Substances : Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17), Inflammatory : CK(150) : AC(37)

Fructose has been strongly linked with hypertension, hyperuricemia and inflammation in experimental models and humans.

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Pubmed Data : Nephrol Dial Transplant. 2011 May 25. Epub 2011 May 25. PMID: 21613382

Article Published Date : May 25, 2011

Study Type : Human Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension : CK(2783) : AC(271), Hyperuricemia : CK(253) : AC(32), Inflammation : CK(1077) : AC(363)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Hypertensive : CK(68) : AC(9), Inflammatory : CK(150) : AC(37)

Gluten elicits its harmful effect, throughout an IL15 innate immune response, on all the individuals.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Gut. 2007 Jun;56(6):889-90. PMID: 17519496

Article Published Date : Oct 21, 1976

Study Type : Human Study

Additional Links

Diseases : Gastrointestinal Inflammation : CK(41) : AC(7)

Problem Substances : Gliadin : CK(2509) : AC(110), Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Interleukin-15 downregulation : CK(11) : AC(2)

Industrially produced trans fatty acids increase tumor necrosis factor, an indicator of systemic inflammation.

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Pubmed Data : J Lipid Res. 2011 Jul 27. Epub 2011 Jul 27. PMID: 21795740

Article Published Date : Jul 27, 2011

Study Type : Human Study

Additional Links

Diseases : Experimental Lung Inflammation : CK(361) : AC(1)

Problem Substances : Trans Fatty Acids : CK(281) : AC(39)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Tumor necrosis factorα (TNFα) up-regulation : CK(42) : AC(4)

Iron fortification results in an unfavorable ratio of fecal enterobacteria to bifidobacteria and lactobacilli associated with gut inflammation in African children.

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Pubmed Data : Am J Clin Nutr. 2010 Dec;92(6):1406-15. Epub 2010 Oct 20. PMID: 20962160

Article Published Date : Dec 01, 2010

Study Type : Human Study

Additional Links

Diseases : Dysbiosis : CK(123) : AC(30), Gastrointestinal Inflammation : CK(41) : AC(7)

Problem Substances : Industrial Iron : CK(102) : AC(15)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

Statin drug use is associated with a significantly increased risk of rheumatoid arthritis.

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Pubmed Data : Ann Rheum Dis. 2011 Oct 6. Epub 2011 Oct 6. PMID: 21979000

Article Published Date : Oct 06, 2011

Study Type : Human Study

Additional Links

Diseases : Rheumatoid Arthritis : CK(424) : AC(64)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

Statin use is associated with worsening symptoms in osteoarthritis of the knee.

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Pubmed Data : Ann Rheum Dis. 2012 Nov 21. Epub 2012 Nov 21. PMID: 23172752

Article Published Date : Nov 20, 2012

Study Type : Human Study

Additional Links

Diseases : Osteoarthritis: Knee : CK(357) : AC(38)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Arthritic : CK(10) : AC(1), Inflammatory : CK(150) : AC(37)

Celiac disease and autoimmune pancreatitis: a case report.

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Pubmed Data : Eur J Gastroenterol Hepatol. 2011 Nov ;23(12):1270-2. PMID: 21946127

Article Published Date : Oct 31, 2011

Study Type : Human: Case Report

Additional Links

Diseases : Celiac Disease : CK(1527) : AC(215), Pancreatitis : CK(164) : AC(40)

Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Problem Substances : Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

Pravastatin-induced colitis has been reported.

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Pubmed Data : Eur J Gastroenterol Hepatol. 2008 Aug ;20(8):810-2. PMID: 18617789

Article Published Date : Aug 01, 2008

Study Type : Human: Case Report

Additional Links

Diseases : Colitis : CK(368) : AC(53), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

Ulcerative colitis after statin treatment has been reported.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Postgrad Med J. 2002 May ;78(919):286-7. PMID: 12151572

Article Published Date : May 01, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Statin-Induced Pathologies : CK(1570) : AC(315), Ulcerative Colitis : CK(429) : AC(39)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

"Gluten-free diet reduces adiposity, inflammation and insulin resistance associated with the induction of PPAR-alpha and PPAR-gamma expression."

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Pubmed Data : J Nutr Biochem. 2012 Dec 17. Epub 2012 Dec 17. PMID: 23253599

Article Published Date : Dec 16, 2012

Study Type : Animal Study

Additional Links

Diseases : Metabolic Syndrome X : CK(645) : AC(122), Overweight : CK(2176) : AC(342)

Therapeutic Actions : Dietary Modification: Wheat/Gluten Free : CK(259) : AC(29)

Problem Substances : Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Inflammatory : CK(150) : AC(37)

"Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease."

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Pubmed Data : Dig Dis Sci. 2010 Nov ;55(11):3078-85. Epub 2010 Mar 3. PMID: 20198430

Article Published Date : Nov 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Inflammatory Bowel Diseases : CK(1227) : AC(103), Ulcerative Colitis : CK(429) : AC(39)

Problem Substances : Glycoalkaloids: Solanaceae : CK(5) : AC(3), Potato : CK(43) : AC(11)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

"Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammatory bowel disease."

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Pubmed Data : Inflamm Bowel Dis. 2002 Sep ;8(5):340-6. PMID: 12479649

Article Published Date : Sep 01, 2002

Study Type : Animal Study

Additional Links

Substances : Potato : CK(71) : AC(31)

Diseases : Inflammatory Bowel Diseases : CK(1227) : AC(103), Intestinal Permeability : CK(224) : AC(53)

Problem Substances : Chaconine : CK(3) : AC(2), Glycoalkaloids: Solanaceae : CK(5) : AC(3), Potato : CK(43) : AC(11), Solanine : CK(3) : AC(2)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

"Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep."

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Pubmed Data : Inhal Toxicol. 2011 Mar ;23(4):205-11. PMID: 21456953

Article Published Date : Mar 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Allergic Airway Diseases : CK(41) : AC(17), Asthma : CK(918) : AC(134), Red Tide Associated Toxicity : CK(70) : AC(16)

Problem Substances : Brevetoxin : CK(38) : AC(13)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

2-chlorobenzalmalononitrile (tear gas) exhibits a wide range of serious, unintended adverse effects including death.

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Pubmed Data : Natl Toxicol Program Tech Rep Ser. 1990 Mar ;377:1-211. PMID: 12692644

Article Published Date : Mar 01, 1990

Study Type : Animal Study

Additional Links

Diseases : Blepharospasm : CK(2) : AC(1), Erythema : CK(44) : AC(6), Listlessness : CK(2) : AC(1), Mouth Breathing : CK(2) : AC(1), Nasal Discharge : CK(2) : AC(1), Respiratory Diseases : CK(174) : AC(29)

Problem Substances : 2-chlorobenzalmalononitrile (tear gas) : CK(2) : AC(1), CS2 Riot Control Aerosol : CK(2) : AC(1)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

A high fructose diet may contribute to the development of fatty liver, gluconeogenesis up-regulation and inflammation.

Click here to read the entire abstract

Pubmed Data : Endocrinology. 2010 May;151(5):2040-9. Epub 2010 Mar 8. PMID: 20211973

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Fatty Liver : CK(493) : AC(122), Fructose-Induced Toxicity : CK(138) : AC(49), Hyperglycemia : CK(2892) : AC(59), Inflammation : CK(1077) : AC(363), Liver Stress: Fructose-Induced : CK(19) : AC(10), Triglycerides: Elevated : CK(340) : AC(65)

Problem Substances : Insulin : CK(92) : AC(15)

Adverse Pharmacological Actions : Dyslipidemic : CK(22) : AC(7), Gluconeogenesis Up-Regulation : CK(8) : AC(4), Inflammatory : CK(150) : AC(37), Lipogenesis Up-Regulation : CK(10) : AC(6)

Dietary gluten alters the balance of proinflammatory and anti-inflammatory cytokines in T cells of BALB/c mice, indicating that gluten may contribute to increased incidence of type 1 diabetes.

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Pubmed Data : Immunology. 2012 Aug 22. Epub 2012 Aug 22. PMID: 22913724

Article Published Date : Aug 21, 2012

Study Type : Animal Study

Additional Links

Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Diabetes Mellitus: Type 1: Prevention : CK(197) : AC(30), Inflammation : CK(1077) : AC(363)

Problem Substances : Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

Fluoride and arsenic exhibit cardiotoxic properties related to their pro-inflammatory effect.

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Pubmed Data : Arch Toxicol. 2012 Mar 16. Epub 2012 Mar 16. PMID: 22422340

Article Published Date : Mar 16, 2012

Study Type : Animal Study

Additional Links

Diseases : Cardiovascular Diseases : CK(5138) : AC(641)

Problem Substances : Arsenic : CK(82) : AC(12), Fluoride : CK(264) : AC(45)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Inflammatory : CK(150) : AC(37), Interleukin-6 up-regulation : CK(14) : AC(3), Interleukin-8 up-regulation : CK(2) : AC(1), MCP-1 (CCL2) up-regulation : CK(2) : AC(1), P-selectin upregulation : CK(2) : AC(1), Vascular Cell Adhesion Molecule-1 (VCAM-1) Up-Regulation : CK(2) : AC(1)

Fructose causes renal damage in an animal model of metabolic syndrome.

Click here to read the entire abstract

Pubmed Data : Pediatr Nephrol. 2011 May 1. Epub 2011 May 1. PMID: 21533627

Article Published Date : May 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Kidney Damage : CK(120) : AC(42), Metabolic Syndrome X : CK(645) : AC(122)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Nephrotoxic : CK(162) : AC(38)

Fructose-fed rats exhibit increased inflammation, fibrogenesis and NF-κB activation.

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Pubmed Data : Eur J Pharmacol. 2011 Jun 17. Epub 2011 Jun 17. PMID: 21704028

Article Published Date : Jun 17, 2011

Study Type : Animal Study

Additional Links

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Inflammation : CK(1077) : AC(363), Kidney Damage : CK(120) : AC(42), Kidney Diseases : CK(424) : AC(71), Kidney Fibrosis : CK(10) : AC(5)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Nephrotoxic : CK(162) : AC(38), NF-kappaB up-regulation : CK(3) : AC(2), Oxidant : CK(104) : AC(37), Profibrotic : CK(4) : AC(2)

High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation.

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Pubmed Data : Magnes Res. 2006 Dec;19(4):237-43. PMID: 17402291

Article Published Date : Dec 01, 2006

Study Type : Animal Study

Additional Links

Diseases : Inflammation : CK(1077) : AC(363), Magnesium Deficiency : CK(81) : AC(12), Metabolic Syndrome X : CK(645) : AC(122)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Inflammatory : CK(150) : AC(37)

Ibuprofen augments pro-inflammatory cytokine release and increases mortality in a mouse model of Vibrio vulnificus infection.

Click here to read the entire abstract

Pubmed Data : Microbiol Immunol. 2010 Sep;54(9):542-50. PMID: 20840153

Article Published Date : Sep 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Vibrio Infections : CK(13) : AC(12)

Problem Substances : Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

Injected formaldehyde and Freund's adjuvant are used to induce experimental arthritis - Article 2.

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2010 Oct 19. Epub 2010 Oct 19. PMID: 20920569

Article Published Date : Oct 19, 2010

Study Type : Animal Study

Additional Links

Problem Substances : Formaldehyde : CK(19) : AC(10), Freund adjuvant : CK(21) : AC(11), Vaccine Adjuvants : CK(383) : AC(77)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37)

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