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Article Count - 11
Cumulative Knowledge - 22

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Quick Summary: Current access displays 2 out of 11 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Tamoxifen	11	2	Log in \| Sign up
Acid Violet	2	1	Log in \| Sign up

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Name	Cumulative Knowledge	Article Count	Focus Articles
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View the Evidence: Adverse Pharmacological Actions

Tamoxifen causes DNA adducs in the endometrium of women.

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Pubmed Data : Carcinogenesis. 2000 Aug;21(8):1461-7. PMID: 10910945

Article Published Date : Aug 01, 2000

Study Type : Human Study

Additional Links

Diseases : Endometrial Cancer : CK(269) : AC(45), Endometrial Neoplasms : CK(41) : AC(5)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Genotoxic : CK(146) : AC(61), Mutagenic : CK(22) : AC(11)

Acid violet 7 and its biodegradation products induce chromosome aberrations, lipid peroxidation, and cholinesterase inhibition in mouse bone marrow.

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Pubmed Data : Environ Sci Pollut Res Int. 2010 Aug;17(7):1371-8. Epub 2010 Apr 6. PMID: 20369386

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Oxidative Stress : CK(1945) : AC(710)

Problem Substances : Acid Violet : CK(2) : AC(1)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Mutagenic : CK(22) : AC(11)

Environmentally relevant concentrations of ammonium perchlorate inhibit thyroid function and alter sex ratios in developing Xenopus laevis.

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Pubmed Data : Environ Toxicol Chem. 2002 Mar;21(3):590-7. PMID: 11878472

Article Published Date : Mar 01, 2002

Study Type : Animal Study

Additional Links

Problem Substances : Perchlorate : CK(100) : AC(28)

Adverse Pharmacological Actions : Mutagenic : CK(22) : AC(11), Teratogenic : CK(304) : AC(59)

Acrylamide and its analogues exhibit mutagenicity in vitro.

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Pubmed Data : Mutat Res. 1985 Dec;158(3):129-33. PMID: 3908926

Article Published Date : Dec 01, 1985

Study Type : In Vitro Study

Additional Links

Problem Substances : Acrylamide : CK(33) : AC(3)

Adverse Pharmacological Actions : Mutagenic : CK(22) : AC(11)

Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines at exceedingly small concentrations (.5 ppm to 10 ppm).

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Pubmed Data : Toxicology. 2009 Aug 21;262(3):184-91. Epub 2009 Jun 17. PMID: 19539684

Article Published Date : Aug 21, 2009

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Additional Keywords : Estrogen Receptor Beta : CK(24) : AC(11)

Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)

Adverse Pharmacological Actions : Cytotoxic : CK(73) : AC(35), Endocrine Disruptor : CK(478) : AC(81), Mutagenic : CK(22) : AC(11)

Public swimming pools disinfected with either chlorine or bromine contain more than 100 disinfection by-products which may contribute to mutagenicity.

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Pubmed Data : Environ Health Perspect. 2010 Sep 12. Epub 2010 Sep 12. PMID: 20833605

Article Published Date : Sep 12, 2010

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Problem Substances : Disinfection by-products: Indoor Swimming Pools : CK(13) : AC(3)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Mutagenic : CK(22) : AC(11)

Retinyl palmitate is photomutagenic in combination with UVA exposure in mouse lymphoma cells, with a clastogenic mode-of-action.

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Pubmed Data : Toxicol Sci. 2005 Nov;88(1):142-9. Epub 2005 Aug 17. PMID: 16107546

Article Published Date : Nov 01, 2005

Study Type : In Vitro Study

Additional Links

Problem Substances : Retinyl palmitate : CK(17) : AC(5)

Adverse Pharmacological Actions : Clastogenic : CK(6) : AC(2), Mutagenic : CK(22) : AC(11), Photomutagenic : CK(1) : AC(1)

Roundup herbicide and its active ingredient glyphosate isopropylamine is genotoxic.

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Pubmed Data : Mutat Res. 1993 Jun;300(1):29-36. PMID: 7683765

Article Published Date : Jun 01, 1993

Study Type : In Vitro Study

Additional Links

Problem Substances : Glyphosate : CK(365) : AC(116), Isopropylamine (IPA) : CK(4) : AC(4), Roundup (herbicide) : CK(365) : AC(116)

Adverse Pharmacological Actions : Mutagenic : CK(22) : AC(11)

Sodium selenite exhibits mutagenic and DNA-damaging effects in a yeast model.

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Pubmed Data : Mutat Res. 2008 Feb 1 ;638(1-2):1-10. Epub 2007 Aug 22. PMID: 17900630

Article Published Date : Feb 01, 2008

Study Type : Plant Study

Additional Links

Diseases : DNA damage : CK(711) : AC(293)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775)

Additional Keywords : Saccharomyces Cerevisiae : CK(4) : AC(4)

Problem Substances : Sodium Selenite : CK(21) : AC(15)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Mutagenic : CK(22) : AC(11)

Tamoxifen induces lesions in endometrial tissues associated with DNA damage and cancer.

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Pubmed Data : Cancer Res. 1999 May 1;59(9):2091-5. PMID: 10232593

Article Published Date : May 01, 1999

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer : CK(2354) : AC(621)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117), Genotoxic : CK(146) : AC(61), Mutagenic : CK(22) : AC(11)

Tamoxifen is genotoxic and carcinogenic to endometrial cells.

Click here to read the entire abstract

Pubmed Data : Drug Metab Rev. 2004 May;36(2):199-218. PMID: 15237851

Article Published Date : May 01, 2004

Study Type : In Vitro Study

Additional Links

Diseases : Endometrial Cancer : CK(269) : AC(45), Endometrial Neoplasms : CK(41) : AC(5)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Paracetamol : CK(44) : AC(6)

Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Mutagenic : CK(22) : AC(11)

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