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Additional Topics Details for this Page
Article Count
- 79
Cumulative Knowledge
- 327
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Quick Summary: Current access displays 2 out of 10 associated Problem Substances
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Focus Articles
Statin Drugs
238
57
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Quick Summary: Current access displays 2 out of 57 associated Diseases
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View the Evidence: Adverse Pharmacological Actions
Muscle complaints occur in 10% or more of patients started on high-dose statins.
Click here to read the entire abstract
Pubmed Data
: Curr Opin Lipidol. 2007 Aug;18(4):401-8. PMID:
17620856
Article Published Date
: Aug 01, 2007
Study Type
: Meta Analysis
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
After a six-month administration of coenzyme Q10, muscle pain and sensitivity statistically significantly decreased.
Click here to read the entire abstract
Pubmed Data
: Neuro Endocrinol Lett. 2012 Nov 28 ;33(Suppl2):98-101. Epub 2012 Nov 28. PMID:
23183519
Article Published Date
: Nov 27, 2012
Study Type
: Human Study
Additional Links
Substances
:
Coenzyme Q10 : CK(667) : AC(104)
Diseases
:
Death: Statin-Induced : CK(14) : AC(3)
,
Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Among top sports performers only about 20% tolerate statin treatment without side-effects.
Click here to read the entire abstract
Pubmed Data
: Br J Clin Pharmacol. 2004 Apr ;57(4):525-8. PMID:
15025753
Article Published Date
: Apr 01, 2004
Study Type
: Human Study
Additional Links
Diseases
:
Athletic Performance : CK(479) : AC(61)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Exercise exacerbates cerivastatin-induced skeletal muscle toxicity.
Click here to read the entire abstract
Pubmed Data
: Toxicol Sci. 2005 Dec ;88(2):551-61. Epub 2005 Sep 1. PMID:
16141437
Article Published Date
: Dec 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Athletic Performance : CK(479) : AC(61)
,
Creatine Phosphokinase (CK): Elevated : CK(75) : AC(9)
,
GGT : CK(73) : AC(10)
,
Muscle Damage: Exercise-Induced : CK(71) : AC(12)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Exposure to atorvastatin is associated with lactone and acid metabolites that are increased several-fold in patients with atorvastatin-induced myopathy.
Click here to read the entire abstract
Pubmed Data
: Clin Pharmacol Ther. 2006 Jun ;79(6):532-9. PMID:
16765141
Article Published Date
: Jun 01, 2006
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Lovastatin increases exercise-induced skeletal muscle injury in human subjects.
Click here to read the entire abstract
Pubmed Data
: Metabolism. 1997 Oct ;46(10):1206-10. PMID:
9322808
Article Published Date
: Oct 01, 1997
Study Type
: Human Study
Additional Links
Diseases
:
Athletic Performance : CK(479) : AC(61)
,
Creatine Phosphokinase (CK): Elevated : CK(75) : AC(9)
,
Muscle Damage: Exercise-Induced : CK(71) : AC(12)
,
Muscle Soreness: Exercise-Induced : CK(114) : AC(13)
,
Muscle Stiffness: Exercise-Induced : CK(20) : AC(2)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Musclar side effects associated with statin drug use are related to oxidative stress.
Click here to read the entire abstract
Pubmed Data
: J Clin Pharm Ther. 2001 Aug ;26(4):303-10. PMID:
11493374
Article Published Date
: Aug 01, 2001
Study Type
: Human Study
Additional Links
Diseases
:
Creatine Phosphokinase (CK): Elevated : CK(75) : AC(9)
,
Isoprostane 8-epi-PGF2alpha: Elevated : CK(10) : AC(1)
,
Myalgias : CK(105) : AC(14)
,
Oxidative Stress : CK(1945) : AC(710)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
,
Oxidant : CK(104) : AC(37)
Myopathy prevalence is underestimated; in an outpatient cardiology clinic prevalence was found to be 33%.
Click here to read the entire abstract
Pubmed Data
: Curr Med Res Opin. 2012 Jun 11. Epub 2012 Jun 11. PMID:
22686958
Article Published Date
: Jun 11, 2012
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Review: muscle symptoms associated with lipid-lowering drugs.
Click here to read the entire abstract
Pubmed Data
: Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):459-65. PMID:
15107601
Article Published Date
: Sep 01, 2003
Study Type
: Human Study
Additional Links
Diseases
:
Muscle Disorders : CK(33) : AC(4)
,
Muscle Fatigue : CK(24) : AC(4)
,
Myalgias : CK(105) : AC(14)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Some 10% to 20% of heart transplant patients appear to suffer adverse side effects of initial statin therapy.
Click here to read the entire abstract
Pubmed Data
: Transplant Proc. 2005 Nov ;37(9):4071-3. PMID:
16386629
Article Published Date
: Nov 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Muscle Soreness : CK(25) : AC(5)
,
Myalgias : CK(105) : AC(14)
,
Organ Transplantation: Heart : CK(34) : AC(5)
,
Rhabdomyolysis : CK(165) : AC(38)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
,
Pravastatin : CK(239) : AC(40)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Hepatotoxic : CK(283) : AC(80)
,
Myotoxicity : CK(317) : AC(79)
Statin drugs have been linked to myopathy, including rhabdomyolysis.
Click here to read the entire abstract
Pubmed Data
: Arch Intern Med. 2005 Dec 12-26;165(22):2671-6. PMID:
16344427
Article Published Date
: Dec 12, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Rhabdomyolysis : CK(165) : AC(38)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin drugs induce ultrastructural damage in skeletal muscle in patients without myalgia.
Click here to read the entire abstract
Pubmed Data
: J Pathol. 2006 Sep ;210(1):94-102. PMID:
16799920
Article Published Date
: Sep 01, 2006
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
,
Pravastatin : CK(239) : AC(40)
,
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin drugs, particularly simivastatin, increase the risk for significant creatine kinase elevation.
Click here to read the entire abstract
Pubmed Data
: Am J Cardiovasc Drugs. 2010 ;10(3):187-92. PMID:
20524720
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Creatine Phosphokinase (CK): Elevated : CK(75) : AC(9)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin therapy can be associated with high blood lactate/ pyruvate ratio suggestive of mitochondrial dysfunction.
Click here to read the entire abstract
Pubmed Data
: Br J Clin Pharmacol. 1996 Sep ;42(3):333-7. PMID:
8877024
Article Published Date
: Sep 01, 1996
Study Type
: Human Study
Additional Links
Diseases
:
Blood Lactate/ Pyruvate Ratio: Elevated : CK(10) : AC(1)
,
Coenzyme Q10 Deficiency : CK(83) : AC(13)
,
Mitochondrial Dysfunction : CK(149) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Enzyme Inhibitors : CK(372) : AC(208)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin-associated myopathy is underestimated and occurs in 5-10% of patients who receive them.
Click here to read the entire abstract
Pubmed Data
: Int J Cardiol. 2011 Aug 1. Epub 2011 Aug 1. PMID:
21813193
Article Published Date
: Aug 01, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin-Associated Polymyalgia Rheumatica
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2012 ;7(7):e41289. Epub 2012 Jul 23. PMID:
22844450
Article Published Date
: Dec 31, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Polymyalgia Rheumatica : CK(63) : AC(7)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin-induced muscle toxicity may be associated with altered oxidation of fatty acids.
Click here to read the entire abstract
Pubmed Data
: Endocrine. 2009 Feb;35(1):38-46. Epub 2008 Dec 3. PMID:
19051066
Article Published Date
: Feb 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
Drug-Induced Toxicity : CK(560) : AC(78)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Lovastatin : CK(265) : AC(67)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin-induced myalgia occurs in∼10% of lipid clinic outpatients.
Click here to read the entire abstract
Pubmed Data
: Atherosclerosis. 2011 Jul 20. Epub 2011 Jul 20. PMID:
21868014
Article Published Date
: Jul 20, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Myalgias : CK(105) : AC(14)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin-induced myopathic weakness causing disability is an underappreciated side effect.
Click here to read the entire abstract
Pubmed Data
: Neurorehabil Neural Repair. 2005 Sep ;19(3):259-63. PMID:
16093417
Article Published Date
: Sep 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statins appear to cause muscle damage and impair oxidative metabolism.
Click here to read the entire abstract
Pubmed Data
: J Submicrosc Cytol Pathol. 2004 Jan ;36(1):85-9. PMID:
15311678
Article Published Date
: Jan 01, 2004
Study Type
: Human Study
Additional Links
Diseases
:
Mitochondrial Dysfunction : CK(149) : AC(51)
,
Mitochondrial Myopathies : CK(46) : AC(9)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statins increase exercise-related muscle injury, which worsens with the age of the individual.
Click here to read the entire abstract
Pubmed Data
: Am J Cardiol. 2011 Oct 27. Epub 2011 Oct 27. PMID:
22036108
Article Published Date
: Oct 27, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Muscle Damage: Exercise-Induced : CK(71) : AC(12)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
A case of simvastatin-induced acute rhabdomyolysis with heart failure after initiation of treatment with fusidic acid has been reported.
Click here to read the entire abstract
Pubmed Data
: Rev Rhum Mal Osteoartic. 1992 Apr ;59(4):281-3. PMID:
1496277
Article Published Date
: Apr 01, 1992
Study Type
: Human: Case Report
Additional Links
Diseases
:
Congestive Heart Failure : CK(256) : AC(33)
,
Rhabdomyolysis : CK(165) : AC(38)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions
:
Cardiotoxic : CK(638) : AC(79)
,
Myotoxicity : CK(317) : AC(79)
A dermatomyositis-like syndrome has been linked to statin drug use.
Click here to read the entire abstract
Pubmed Data
: Muscle Nerve. 2004 Dec ;30(6):803-7. PMID:
15389654
Article Published Date
: Dec 01, 2004
Study Type
: Human: Case Report
Additional Links
Diseases
:
Dermatomyositis : CK(44) : AC(10)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
A possible increased risk of rhabdomyolysis during concomitant use of simvastatin and gemfibrozil has been reported.
Click here to read the entire abstract
Pubmed Data
: J Intern Med. 1996 Dec ;240(6):403-4. PMID:
9010388
Article Published Date
: Dec 01, 1996
Study Type
: Human: Case Report
Additional Links
Diseases
:
Rhabdomyolysis : CK(165) : AC(38)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Additional Keywords
:
Drug Synergy : CK(327) : AC(147)
Problem Substances
:
Fenofibrates : CK(133) : AC(19)
,
Gemfibrozil : CK(3) : AC(1)
,
Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Asymptomatic statin-induced rhabdomyolysis after long-term therapy with the hydrophilic drug pravastatin has been reported.
Click here to read the entire abstract
Pubmed Data
: Clin Ther. 2007 Jan ;29(1):172-6. PMID:
17379057
Article Published Date
: Jan 01, 2007
Study Type
: Human: Case Report
Additional Links
Diseases
:
Rhabdomyolysis : CK(165) : AC(38)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Pravastatin : CK(239) : AC(40)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
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