Nephrotoxic

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View the Evidence: Adverse Pharmacological Actions

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.

Pubmed Data : Pediatr Nephrol. 2005 Sep;20(9):1295-8. Epub 2005 Jun 23. PMID: 15973524
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Children: Drug-Induced Toxicity : CK(10) : AC(1)
Problem Substances : Diclofenac : CK(72) : AC(7), Dipyrone : CK(10) : AC(1), Ibuprofen : CK(162) : AC(19), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Paracetamol : CK(44) : AC(6)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Consumption of≥2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women.

Pubmed Data : Clin J Am Soc Nephrol. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20884773
Article Published Date : Sep 30, 2010
Study Type : Human Study
Additional Links
Diseases : Diabetes: Kidney Function : CK(75) : AC(22), Kidney Damage : CK(120) : AC(42), Kidney Diseases : CK(424) : AC(71), Kidney Failure : CK(668) : AC(41)
Problem Substances : Artificial Sweeteners : CK(209) : AC(51), Artificially Sweetened Beverages : CK(23) : AC(2), Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Fenofibrates therapy is associated with deterioration of renal function.

Pubmed Data : Clin Nephrol. 2001 Jan;55(1):39-44. PMID: 11200866
Article Published Date : Jan 01, 2001
Study Type : Human Study
Additional Links
Diseases : Hyperlipidemia : CK(1211) : AC(109), Kidney Damage: Drug-Induced : CK(86) : AC(22)
Problem Substances : Fenofibrates : CK(133) : AC(19)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Fibrate-induced deterioration of renal function has been reported.

Pubmed Data : Nefrologia. 2009;29(3):208-13. PMID: 19554053
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Kidney Damage: Drug-Induced : CK(86) : AC(22)
Problem Substances : Fenofibrates : CK(133) : AC(19)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Gluten sensitivity is prevalent in patients with IgA nephropathy.

Pubmed Data : Nephrol Dial Transplant. 2009 Aug;24(8):2476-81. Epub 2009 Mar 30. PMID: 19332868
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Diseases : Gluten Intolerance : CK(236) : AC(33), IgA Nephropathy : CK(186) : AC(22)
Problem Substances : Gliadin : CK(2509) : AC(110)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Sugary soda consumption is associated with kidney damage.

Pubmed Data : PLoS One. 2008;3(10):e3431. Epub 2008 Oct 17. PMID: 18927611
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Diseases : Diabetes: Kidney Function : CK(75) : AC(22), Kidney Damage : CK(120) : AC(42), Kidney Diseases : CK(424) : AC(71), Kidney Failure : CK(668) : AC(41)
Problem Substances : High Fructose Corn Syrup : CK(67) : AC(10), Sugary soda : CK(149) : AC(20)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

The FDA adverse event reporting system reveals statin-associated muscular and renal adverse events.

Pubmed Data : PLoS One. 2011 ;6(12):e28124. Epub 2011 Dec 20. PMID: 22205938
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Creatine Phosphokinase (CK): Elevated : CK(75) : AC(9), Death: Statin-Induced : CK(14) : AC(3), Kidney Failure: Acute : CK(51) : AC(11), Myalgias : CK(105) : AC(14), Rhabdomyolysis : CK(165) : AC(38)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

There is a dose-response relationship in statin-induced rhabdomyolysis.

Pubmed Data : Can J Cardiol. 2011 Mar-Apr;27(2):146-51. PMID: 21459261
Article Published Date : Mar 01, 2011
Study Type : Human Study
Additional Links
Diseases : Kidney Damage: Drug-Induced : CK(86) : AC(22), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

There is an association between prolonged occupational exposure to paraphenylenediamine (hair-dye) and renal impairment.

Pubmed Data : Arab J Nephrol Transplant. 2011 Jan;4(1):21-5. PMID: 21469591
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Kidney Damage : CK(120) : AC(42), Occupation Related Diseases: Hair Dressers : CK(20) : AC(2), Proteinuria : CK(103) : AC(20)
Problem Substances : Paraphenylenediamine (Hair Dye Ingredient) : CK(42) : AC(5)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Use of high potency statins increase rates of admission for acute kidney injury.

Pubmed Data : BMJ. 2013 ;346:f880. Epub 2013 Mar 18. PMID: 23511950
Article Published Date : Dec 31, 2012
Study Type : Human Study
Additional Links
Diseases : Kidney Failure: Acute : CK(51) : AC(11)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Zolendronic acid results in renal impairment in 23,8% of the prostate cancer patients it is administered to.

Pubmed Data : Cancer. 2007 Mar 15;109(6):1090-6. PMID: 17311345
Article Published Date : Mar 15, 2007
Study Type : Human Study
Additional Links
Diseases : Kidney Damage: Drug-Induced : CK(86) : AC(22), Prostate Cancer : CK(998) : AC(288)
Problem Substances : Bisphosphonates : CK(496) : AC(61), Zoledronic Acid : CK(69) : AC(13)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

"A child with atypical celiac disease and recurrent urolithiasis."

Pubmed Data : Iran J Kidney Dis. 2012 Mar ;6(2):146-8. PMID: 22388615
Article Published Date : Mar 01, 2012
Study Type : Human: Case Report
Additional Links
Diseases : Hydronephrosis : CK(3) : AC(1), Kidney Stones : CK(157) : AC(28), Urolithiasis : CK(8) : AC(5)
Problem Substances : Wheat : CK(2542) : AC(309)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

A case of acute kidney injury related to intravenous zoledronic acid in a patient with multiple myeloma has been reported.

Pubmed Data : Nippon Jinzo Gakkai Shi. 2009;51(5):557-62. PMID: 19715164
Article Published Date : Jan 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Damage: Drug-Induced : CK(86) : AC(22)
Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)
Problem Substances : Bisphosphonates : CK(496) : AC(61), Dexamethasone : CK(49) : AC(8), Zoledronic Acid : CK(69) : AC(13)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Acute interstitial nephritis due to mesalazine has been reported.

Pubmed Data : Nephrology (Carlton). 2005 Apr;10(2):103-5. PMID: 15877665
Article Published Date : Apr 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Nephritis : CK(29) : AC(6), Renal tubulointerstitial fibrosis : CK(15) : AC(7), Ulcerative Colitis : CK(429) : AC(39)
Problem Substances : Mesalamine : CK(41) : AC(8), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Acute renal failure with the combined use of rosuvastatin and fenofibrate has been reported.

Pubmed Data : Ren Fail. 2010 Jun;32(5):633-5. PMID: 20486848
Article Published Date : Jun 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Failure: Acute : CK(51) : AC(11)
Problem Substances : Fenofibrates : CK(133) : AC(19), Rosuvastatin : CK(68) : AC(16), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Lovastatin monotherapy has been reported to have been a cause of rhabdomyolysis, acute renal failure and hepatopathy.

Pubmed Data : Jpn Heart J. 1997 Jul ;38(4):541-5. PMID: 9350151
Article Published Date : Jul 01, 1997
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Kidney Failure: Acute : CK(51) : AC(11), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Simvastatin-induced rhabdomyolysis and acute renal injury has been reported.

Pubmed Data : Blood Purif. 2008 ;26(4):394-8. Epub 2008 Jul 1. PMID: 18594138
Article Published Date : Jan 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Damage: Drug-Induced : CK(86) : AC(22), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Statin toxicity may mimic viral hepatitis.

Pubmed Data : Int J Clin Pharmacol Ther. 2005 Nov ;43(11):543-5. PMID: 16300170
Article Published Date : Nov 01, 2005
Study Type : Human: Case Report
Additional Links
Diseases : Hepatitis: Acute : CK(13) : AC(2), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79), Nephrotoxic : CK(162) : AC(38)

Terminal renal failure in lovastatin therapy with pre-existing chronic renal insufficiency has been reported.

Pubmed Data : Wien Klin Wochenschr. 1996 ;108(11):334-7. PMID: 8767987
Article Published Date : Jan 01, 1996
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Damage: Drug-Induced : CK(86) : AC(22), Kidney Failure: Chronic : CK(134) : AC(19), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Varenicline-associated acute renal failure has been reported.

Pubmed Data : Ann Pharmacother. 2008 Dec;42(12):1908-11. Epub 2008 Nov 4. PMID: 18984856
Article Published Date : Dec 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Damage : CK(120) : AC(42), Kidney Damage: Drug-Induced : CK(86) : AC(22)
Problem Substances : Varenicline (trade name Chantix) : CK(39) : AC(5)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

"Pomegranate Extract Attenuates Gentamicin-Induced Nephrotoxicity in Rats by Reducing Oxidative Stress."

Pubmed Data : Ren Fail. 2012 Nov 26. Epub 2012 Nov 26. PMID: 23176634
Article Published Date : Nov 25, 2012
Study Type : Animal Study
Additional Links
Substances : Pomegranate : CK(146) : AC(61)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(22) : AC(10), Kidney Damage: Chemically-Induced : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90)
Additional Keywords : Drug: Gentamicin : CK(2) : AC(1)
Problem Substances : Gentamicin : CK(2) : AC(1)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

,4-Dichlorophenoxyacetic acid exhibits nephrotoxic properties.

Pubmed Data : Ecotoxicol Environ Saf. 2011 Nov ;74(8):2316-23. Epub 2011 Aug 11. PMID: 21835467
Article Published Date : Nov 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Kidney Damage : CK(120) : AC(42)
Problem Substances : 2
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Acetaminophen (Tylenol) includes the toxicity associated with chronic exposure to depleted uranium.

Pubmed Data : Toxicology. 2007 Jan 5;229(1-2):62-72. Epub 2006 Oct 17. PMID: 17126469
Article Published Date : Jan 05, 2007
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Uranium Poisoning : CK(28) : AC(19)
Additional Keywords : Toxic Substance Synergy : CK(5) : AC(3)
Problem Substances : Tylenol : CK(125) : AC(13), Uranium : CK(46) : AC(21)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Nephrotoxic : CK(162) : AC(38)

Berberine protects against fructose-and-salt induced hypertensive renal injury.

Pubmed Data : Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID: 21823461
Article Published Date : Mar 01, 2011
Study Type : Animal Study
Additional Links
Substances : Berberine : CK(156) : AC(75)
Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension: Renal : CK(2) : AC(1), Kidney Diseases : CK(424) : AC(71)
Pharmacological Actions : Renoprotective : CK(191) : AC(90)
Problem Substances : Fructose : CK(356) : AC(103), Sodium Chloride : CK(14) : AC(3)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Dietary fructose causes tubulointerstitial injury in the normal rat kidney.

Pubmed Data : Am J Physiol Renal Physiol. 2010 Mar;298(3):F712-20. Epub 2010 Jan 13. PMID: 20071464
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Renal tubulointerstitial fibrosis : CK(15) : AC(7)
Problem Substances : Fructose : CK(356) : AC(103)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

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