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Article Count - 179
Cumulative Knowledge - 1078

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Quick Summary: Current access displays 2 out of 85 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
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View the Evidence: Adverse Pharmacological Actions

As thimerosal was removed from childhood vaccines, the number of neurodevelopmental disorders decreased in the US.

Click here to read the entire abstract

Pubmed Data : Med Sci Monit. 2006 Jun;12(6):CR231-9. Epub 2006 May 29. PMID: 16733480

Article Published Date : Jun 01, 2006

Study Type : Meta Analysis

Additional Links

Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Neurodevelopmental Disorders : CK(163) : AC(13), Vaccine-induced Toxicity : CK(1130) : AC(163)

Problem Substances : Thimerosal : CK(351) : AC(22)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Children who live in a fluorosis area have 5 times higher odds of developing low IQ than those who live in a nonfluorosis area or a slight fluorosis area.

Click here to read the entire abstract

Pubmed Data : Biol Trace Elem Res. 2008;126(1-3):115-20. Epub 2008 Aug 10. PMID: 18695947

Article Published Date : Jan 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Childhood Cognitive Disorders : CK(180) : AC(14), Cognitive Decline/Dysfunction : CK(522) : AC(87), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), Prenatal Nutrition: Learning/Intelligence of Offspring : CK(118) : AC(15)

Problem Substances : Fluoride : CK(264) : AC(45)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Children who live in an arsenicosis area or a slight arsenicosis area have lower IQ than those who live in a non-arsenicosis area.

Click here to read the entire abstract

Pubmed Data : Biol Trace Elem Res. 2009;129(1-3):88-93. Epub 2008 Dec 24. PMID: 19107329

Article Published Date : Jan 01, 2009

Study Type : Meta Analysis

Additional Links

Diseases : Childhood Cognitive Disorders : CK(180) : AC(14), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), Prenatal Chemical Exposures : CK(322) : AC(86)

Problem Substances : Arsenic : CK(82) : AC(12)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Dental amalgams (mercury exposure) increase the risk of multiple sclerosis.

Click here to read the entire abstract

Pubmed Data : J Public Health Dent. 2007;67(1):64-6. PMID: 17436982

Article Published Date : Jan 01, 2007

Study Type : Meta Analysis

Additional Links

Diseases : Mercury Poisoning : CK(162) : AC(44), Multiple Sclerosis : CK(716) : AC(133)

Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Problem Substances : Dental Amalgams : CK(20) : AC(1), Mercury : CK(96) : AC(11)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Exposure to high levels of fluoride may adversely influence children's intelligence development.

Click here to read the entire abstract

Pubmed Data : Zhongguo Dang Dai Er Ke Za Zhi. 2008 Dec;10(6):723-5. PMID: 19102839

Article Published Date : Dec 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Childhood Cognitive Disorders : CK(180) : AC(14), Cognitive Decline/Dysfunction : CK(522) : AC(87), Fluoride Toxicity : CK(146) : AC(40), Fluorosis : CK(219) : AC(6), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), Prenatal Nutrition: Learning/Intelligence of Offspring : CK(118) : AC(15)

Problem Substances : Fluoride : CK(264) : AC(45)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Exposure to mercury from thimerosal-containing vaccines was associcated with an increased risk of neurodevelopmental problems in infants from 1992-1997.

Click here to read the entire abstract

Pubmed Data : Med Sci Monit. 2005 Apr;11(4):CR160-70. Epub 2005 Mar 24. PMID: 15795695

Article Published Date : Apr 01, 2005

Study Type : Meta Analysis

Additional Links

Diseases : Attention Deficit Disorder : CK(134) : AC(12), Learning disorders : CK(154) : AC(36), Neurodevelopmental Disorders : CK(163) : AC(13), Seizures : CK(122) : AC(28), Speech Disorders : CK(30) : AC(2), Tic Disorders : CK(60) : AC(3)

Problem Substances : Thimerosal : CK(351) : AC(22)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Oseltamivir for treatment of influenza in infants less than one year results in complications in 54% of the patients with the most serious of which were meningitis in 1 infant (1%), pneumonia in 9 (6%), and otitis media in 2 (1%)

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Pubmed Data : Pediatr Infect Dis J. 2010 Jun;29(6):495-8. PMID: 20035245

Article Published Date : Jun 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Infant Infections : CK(420) : AC(45), Influenza : CK(654) : AC(102), Meningitis: Drug-Induced : CK(20) : AC(1), Pneumonia: Drug-Induced : CK(24) : AC(3)

Additional Keywords : Iatrogenic Disease : CK(226) : AC(26)

Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Oseltamivir has been reported to cause neuropsychiatric disorders in children and may be particularly dangerous to infants.

Click here to read the entire abstract

Pubmed Data : Prescrire Int. 2006 Oct;15(85):182-3. PMID: 17128526

Article Published Date : Oct 01, 2006

Study Type : Meta Analysis

Additional Links

Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Childhood Cognitive Disorders : CK(180) : AC(14), Lyell syndrome : CK(20) : AC(1), Psychiatric Disorders : CK(71) : AC(10)

Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Prenatal stress inhibits neuronal maturation in offspring.

Click here to read the entire abstract

Pubmed Data : J Neurosci. 2011 Aug 10 ;31(32):11505-14. PMID: 21832180

Article Published Date : Aug 10, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Prenatal Nutrition: Learning/Intelligence of Offspring : CK(118) : AC(15)

Anti Therapeutic Actions : Prenatal Stress : CK(48) : AC(7)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Rates of autism, speech disorders, mental retardation, infantile spasms, and thinking abnormalities were higher in children exposured to higher thimerosal levels.

Click here to read the entire abstract

Pubmed Data : J Toxicol Environ Health A. 2006 Aug;69(15):1481-95. PMID: 16766480

Article Published Date : Aug 01, 2006

Study Type : Meta Analysis

Additional Links

Diseases : Autism : CK(1262) : AC(65), Cognitive Decline/Dysfunction : CK(522) : AC(87), Infantile Spasms : CK(50) : AC(4), Mental Retardation : CK(71) : AC(7), Neurodevelopmental Disorders : CK(163) : AC(13)

Problem Substances : Thimerosal : CK(351) : AC(22)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Tamoxifen interferes with cognitive function in breast cancer patients.

Click here to read the entire abstract

Pubmed Data : Breast Cancer Res Treat. 2000 Nov;64(2):165-76. PMID: 11194452

Article Published Date : Nov 01, 2000

Study Type : Meta Analysis

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Drug-Induced Toxicity : CK(560) : AC(78), Memory Disorders: Drug-Induced : CK(77) : AC(12)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

The WHO reports 71,471 seizures from a variety of neuroactive drugs between 1968-2006.

Click here to read the entire abstract

Pubmed Data : Seizure. 2010 Mar;19(2):69-73. Epub 2009 Dec 24. PMID: 20036167

Article Published Date : Mar 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Seizures : CK(122) : AC(28)

Problem Substances : Amoxapine : CK(20) : AC(1), Buproprione : CK(20) : AC(1), Chlorprothiexene : CK(20) : AC(1), Clozapine : CK(20) : AC(1), Donepezil (trade name Aricept) : CK(89) : AC(8), Escitaloprame : CK(20) : AC(1), Maprotilene : CK(20) : AC(1), Quetiapine : CK(20) : AC(1), Rivastigmine : CK(21) : AC(2), Trimipramine : CK(20) : AC(1)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Thimersol exposure in infants is associated with an increase risk for tics.

Click here to read the entire abstract

Pubmed Data : Pediatrics. 2004 Sep;114(3):584-91. PMID: 15342825

Article Published Date : Sep 01, 2004

Study Type : Meta Analysis

Additional Links

Diseases : Tic Disorders : CK(60) : AC(3)

Problem Substances : Thimerosal : CK(351) : AC(22)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Thimersol exposure is associated with tics and delayed language acquisition in infants.

Click here to read the entire abstract

Pubmed Data : Pediatrics. 2003 Nov;112(5):1039-48. PMID: 14595043

Article Published Date : Nov 01, 2003

Study Type : Meta Analysis

Additional Links

Diseases : Learning disorders : CK(154) : AC(36), Neurodevelopmental Disorders : CK(163) : AC(13), Tic Disorders : CK(60) : AC(3)

Problem Substances : Thimerosal : CK(351) : AC(22)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

A high prevalence of gluten sensitivity is found in sporadic and hereditary cerebellar ataxia.

Click here to read the entire abstract

Pubmed Data : Ann Neurol. 2001 Apr;49(4):540-3. PMID: 11310636

Article Published Date : Apr 01, 2001

Study Type : Human Study

Additional Links

Diseases : Ataxia: Cerebellar : CK(67) : AC(3), Food Allergies : CK(420) : AC(57), Gluten Sensitivity : CK(2477) : AC(270)

Problem Substances : Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Inorg Biochem. 2009 Nov;103(11):1555-62. Epub 2009 Aug 20. PMID: 19740540

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Diseases : Gulf War Syndrome : CK(33) : AC(5)

Additional Keywords : Adjuvant Toxicity : CK(16) : AC(5)

Problem Substances : Aluminum Hydroxide : CK(56) : AC(14)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Aluminum vaccine adjuvants appear to contribute to the rising prevalence of autism.

Click here to read the entire abstract

Pubmed Data : J Inorg Biochem. 2011 Nov ;105(11):1489-99. Epub 2011 Aug 23. PMID: 22099159

Article Published Date : Nov 01, 2011

Study Type : Human Study

Additional Links

Diseases : Autism : CK(1262) : AC(65), Autism Spectrum Disorders : CK(1140) : AC(108)

Anti Therapeutic Actions : Vaccination: All : CK(3830) : AC(302)

Problem Substances : Aluminum Hydroxide : CK(56) : AC(14)

Adverse Pharmacological Actions : Immunotoxic : CK(230) : AC(38), Neurotoxic : CK(1076) : AC(179)

Antigliadin antibodies are found at a higher prevalence in Cuban patients with spinocerebellar ataxia type 2.

Click here to read the entire abstract

Pubmed Data : J Neurol Neurosurg Psychiatry. 2008 Mar ;79(3):315-7. Epub 2007 Oct 19. PMID: 17951282

Article Published Date : Mar 01, 2008

Study Type : Human Study

Additional Links

Diseases : Spinocerebellar Ataxia Type 2 : CK(10) : AC(1)

Additional Keywords : Anti-Gliadin Antibodies : CK(71) : AC(8)

Problem Substances : Gliadin : CK(2509) : AC(110)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Celiac disease is associated with ataxic syndromes without definite diagnosis, suggesting that it plays a part in the pathogenesis of some ataxic syndromes.

Click here to read the entire abstract

Pubmed Data : J Neurol Neurosurg Psychiatry. 1999 Jan ;66(1):32-5. PMID: 9886447

Article Published Date : Jan 01, 1999

Study Type : Human Study

Additional Links

Diseases : Ataxia: Cerebellar : CK(67) : AC(3), Celiac Disease : CK(1527) : AC(215)

Problem Substances : Gliadin : CK(2509) : AC(110)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Children's growth and intelligence can be adversely affected by fluoride and arsenic exposure in drinking water.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 2007 Apr;115(4):643-7. Epub 2007 Jan 9. PMID: 17450237

Article Published Date : Apr 01, 2007

Study Type : Human Study

Additional Links

Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Childhood Cognitive Disorders : CK(180) : AC(14), Children: Impaired Growth : CK(30) : AC(3), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12)

Problem Substances : Arsenic : CK(82) : AC(12), Fluoride : CK(264) : AC(45)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Chronic consumption of proton pump inhibitors may increase the risk for Alzheimer disease.

Click here to read the entire abstract

Pubmed Data : J Clin Pharm Ther. 2010 Apr;35(2):125-6. PMID: 20456731

Article Published Date : Apr 01, 2010

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease : CK(826) : AC(160), Brain: Microglial Activation : CK(67) : AC(38), Neurodegenerative Diseases : CK(1743) : AC(420)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Cigarette smoking is associated with increased risk for ALS.

Click here to read the entire abstract

Pubmed Data : Neuroepidemiology. 1999;18(4):194-202. PMID: 10364720

Article Published Date : Jan 01, 1999

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis : CK(350) : AC(68), Smoking : CK(577) : AC(86)

Problem Substances : Tobacco : CK(74) : AC(7)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Disaster-related prenatal maternal stress influences birth outcomes, including lower head circumference.

Click here to read the entire abstract

Pubmed Data : Early Hum Dev. 2011 Jul 22. Epub 2011 Jul 22. PMID: 21784587

Article Published Date : Jul 22, 2011

Study Type : Human Study

Additional Links

Diseases : Infant Neurological Development : CK(46) : AC(7), Post-Traumatic Stress Disorders : CK(122) : AC(13), Pregnancy: Psychological and Physical Distress. : CK(36) : AC(6)

Anti Therapeutic Actions : Prenatal Stress : CK(48) : AC(7)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Epilepsy with cerebral calcifications of unexplained origin may likely be caused by undiagnosed celiac disease.

Click here to read the entire abstract

Pubmed Data : Lancet. 1992 Aug 22;340(8817):439-43. PMID: 1354781

Article Published Date : Aug 22, 1992

Study Type : Human Study

Additional Links

Diseases : Celiac Disease : CK(1527) : AC(215), Cerebral Calcifications : CK(13) : AC(2), Epilepsy : CK(128) : AC(27), Epilepsy: With Cerebral Calcifications : CK(24) : AC(3)

Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Problem Substances : Gluten : CK(1755) : AC(144), Wheat : CK(2542) : AC(309)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Exposure of pregnant women to emissions of PAHs from the coal-burning plant, in combination with prenatal exposure to envrionmental tobacco smoke, may have adversely affected cognitive function of children at age 5.

Click here to read the entire abstract

Pubmed Data : Environ Res. 2012 Mar 1. Epub 2012 Mar 1. PMID: 22386727

Article Published Date : Mar 01, 2012

Study Type : Human Study

Additional Links

Diseases : Coal-Fired Power Plant Associated Toxicity : CK(30) : AC(3), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), Prenatal Chemical Exposures : CK(322) : AC(86)

Problem Substances : Polycyclic aromatic hydrocarbon: coal-fired power plant associated : CK(30) : AC(3), Tobacco Smoke: Passive : CK(31) : AC(4)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

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