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Article Count - 179
Cumulative Knowledge - 1078

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Quick Summary: Current access displays 2 out of 85 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Statin Drugs	181	39	Log in \| Sign up
Thimerosal	137	10	Log in \| Sign up

Quick Summary: Current access displays 2 out of 157 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Statin-Induced Pathologies	187	44	Log in \| Sign up
Childhood Cognitive Disorders	140	10	Log in \| Sign up

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View the Evidence: Adverse Pharmacological Actions

Autism can be triggered by acetaminophen activation of the endocannabinoid system.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Neurobiol Exp (Wars). 2010;70(2):227-31. PMID: 20628445

Article Published Date : Jan 01, 2010

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Autism Spectrum Disorders : CK(1140) : AC(108), Endocannabinoid Disorders : CK(15) : AC(9)

Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Problem Substances : Tylenol : CK(125) : AC(13)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Celiac disease should be ruled out in the differential diagnosis of neurological dysfunction of unknown cause, including ataxia, epilepsy and dementia.

Click here to read the entire abstract

Pubmed Data : Arq Neuropsiquiatr. 2004 Dec ;62(4):969-72. Epub 2004 Dec 15. PMID: 15608953

Article Published Date : Dec 01, 2004

Study Type : Review

Additional Links

Diseases : Ataxia : CK(96) : AC(14), Celiac Disease : CK(1527) : AC(215), Dementia : CK(225) : AC(31), Epilepsy : CK(128) : AC(27)

Problem Substances : Gluten : CK(1755) : AC(144)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Cognitive impairment associated with statin drug use has been reported.

Click here to read the entire abstract

Pubmed Data : Pharmacotherapy. 2003 Dec ;23(12):1663-7. PMID: 14695047

Article Published Date : Dec 01, 2003

Study Type : Review

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Dementia : CK(225) : AC(31), Memory Disorders : CK(221) : AC(67)

Problem Substances : Atorvastatin : CK(491) : AC(90), Cholesterol Lowering Drugs : CK(2146) : AC(349), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

DEET absorbs through the skin following topical application and may have significant toxicity.

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Pubmed Data : J Toxicol Environ Health. 1986;18(4):503-25. PMID: 3525852

Article Published Date : Jan 01, 1986

Study Type : Commentary

Additional Links

Adverse Pharmacological Actions : Cytotoxic : CK(73) : AC(35), Neurotoxic : CK(1076) : AC(179)

Epstein-Barr virus can infect human Blood-Brain-Barrier cells contributing to multiple sclerosis pathogenesis.

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Pubmed Data : J Neuroimmunol. 2011 Jan;230(1-2):173-7. Epub 2010 Sep 9. PMID: 20826008

Article Published Date : Jan 01, 2011

Study Type : Review

Additional Links

Diseases : Blood-Brain-Barrier Disorders : CK(25) : AC(15), Epstein-Barr Virus Infections : CK(100) : AC(43), Multiple Sclerosis : CK(716) : AC(133)

Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Problem Substances : Epstein-Barr Virus : CK(12) : AC(2)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Exposure to glyphosate- and/or Mn/Zn-ethylene-bis-dithiocarbamate-containing pesticides leads to degeneration ofγ-aminobutyric acid and dopamine neurons in Caenorhabditis elegans.

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Pubmed Data : Neurotox Res. 2012 Apr ;21(3):281-90. Epub 2011 Sep 16. PMID: 21922334

Article Published Date : Apr 01, 2012

Study Type : In Vitro Study

Additional Links

Diseases : Dopamine Levels: Low : CK(4) : AC(1), Glyphosate Toxicity : CK(22) : AC(12), Neurodegenerative Diseases : CK(1743) : AC(420), Neurotoxicity : CK(37) : AC(15), Parkinson Disease : CK(543) : AC(79), Parkinsonian Disorders : CK(15) : AC(4), Substantia Nigra: Damage : CK(3) : AC(1)

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Glyphosate induces cell death through apoptotic and autophagic mechanisms, indicating a mechanism behind the association between glyphosate exposure and Parkinsonism.

Click here to read the entire abstract

Pubmed Data : Neurotoxicol Teratol. 2012 Apr 4. Epub 2012 Apr 4. PMID: 22504123

Article Published Date : Apr 04, 2012

Study Type : In Vitro Study

Additional Links

Diseases : Parkinson Disease : CK(543) : AC(79), Parkinsonian Disorders : CK(15) : AC(4)

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Hormone therapy in postmenopausal women increase the risk of stroke.

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Pubmed Data : Womens Health (Lond Engl). 2011 May ;7(3):355-61. PMID: 21612355

Article Published Date : May 01, 2011

Study Type : Review

Additional Links

Diseases : Stroke : CK(540) : AC(47)

Problem Substances : Hormone Replacement Therapy : CK(81) : AC(6)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin exhibits neurotoxic properties.

Click here to read the entire abstract

Pubmed Data : J Submicrosc Cytol Pathol. 1995 Oct ;27(4):435-44. PMID: 7585443

Article Published Date : Oct 01, 1995

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin induces neuronal cell death through interacting with signal transduction pathways that cell control growth and survival.

Click here to read the entire abstract

Pubmed Data : Mol Cell Neurosci. 2001 Feb ;17(2):329-41. PMID: 11178870

Article Published Date : Feb 01, 2001

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin induces neuronal cell death.

Click here to read the entire abstract

Pubmed Data : J Neurochem. 1999 Jun ;72(6):2278-85. PMID: 10349836

Article Published Date : Jun 01, 1999

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin may adversely affect myelin formation and the remyelination process.

Click here to read the entire abstract

Pubmed Data : J Neurochem. 1994 Apr ;62(4):1539-45. PMID: 8133281

Article Published Date : Apr 01, 1994

Study Type : In Vitro Study

Additional Links

Diseases : Demyelinating Diseases : CK(1278) : AC(250), Statin-Induced Pathologies : CK(1570) : AC(315)

Additional Keywords : Remyelination : CK(15) : AC(10)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in neurons.

Click here to read the entire abstract

Pubmed Data : Neurobiol Aging. 2010 Sep ;31(9):1543-53. Epub 2008 Oct 31. PMID: 18951667

Article Published Date : Sep 01, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Aging : CK(1351) : AC(369), Cognitive Decline/Dysfunction : CK(522) : AC(87), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Apoptotic : CK(1489) : AC(1114)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Mevastatin exhibits potential neurotoxicity.

Click here to read the entire abstract

Pubmed Data : J Neurosci Res. 2002 Jun 1 ;68(5):627-35. PMID: 12111853

Article Published Date : Jun 01, 2002

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Proteasome Inhibitors : CK(41) : AC(27)

Problem Substances : Mevastatin : CK(1) : AC(1)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Neuropsychiatric disorders have been reported in connection with oseltamivir use.

Click here to read the entire abstract

Pubmed Data : Prescrire Int. 2007 Oct;16(91):200. PMID: 17926837

Article Published Date : Oct 01, 2007

Study Type : Commentary

Additional Links

Diseases : Delirium: Drug-Induced : CK(26) : AC(6), Drug-Induced Toxicity : CK(560) : AC(78), Hallucinations : CK(1) : AC(1), Parasuicide : CK(11) : AC(2), Psychiatric Disorders : CK(71) : AC(10), Suicidal Behavior : CK(83) : AC(10)

Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Neurotoxic shellfish poisoning may result from Red tide contaminated seafood.

Click here to read the entire abstract

Pubmed Data : Mar Drugs. 2008 ;6(3):431-55. Epub 2008 Jul 12. PMID: 19005578

Article Published Date : Jan 01, 2008

Study Type : Review

Additional Links

Diseases : Ataxia : CK(96) : AC(14), Dizziness : CK(1) : AC(1), Gastrointestinal Complaints : CK(21) : AC(3), Neurologic Disorders : CK(63) : AC(21), Neurotoxic Shellfish Poisoning : CK(1) : AC(1), Red Tide Associated Toxicity : CK(70) : AC(16)

Problem Substances : Brevetoxin : CK(38) : AC(13), Red tide : CK(69) : AC(16)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Postmortem analysis of Alzheimer brains reveals a loss in membrane cholesterol content, indicating that statin drugs may be contribute to neurodegenerative conditions.

Click here to read the entire abstract

Pubmed Data : Neurol Sci. 2011 Apr ;32(2):195-201. Epub 2010 Oct 19. PMID: 20957505

Article Published Date : Apr 01, 2011

Study Type : Review

Additional Links

Diseases : Neurodevelopmental Disorders : CK(163) : AC(13), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Quinolone antibiotics have been reported to cause neurological and psychiatric adverse effects.

Click here to read the entire abstract

Pubmed Data : Drug Saf. 2011 Jun 1;34(6):465-88. PMID: 21585220

Article Published Date : Jun 01, 2011

Study Type : Review

Additional Links

Diseases : Neurologic Disorders : CK(63) : AC(21)

Problem Substances : Cipro : CK(47) : AC(8), Fluoroquinolone Antibiotic : CK(82) : AC(11)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin exhibits neurotoxic properties.

Click here to read the entire abstract

Pubmed Data : Brain Res. 2000 Mar 17 ;859(1):169-72. PMID: 10720627

Article Published Date : Mar 17, 2000

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin exhibits neurotoxicity in a neuronal cell model.

Click here to read the entire abstract

Pubmed Data : Neurosci Lett. 1996 Dec 6 ;220(1):21-4. PMID: 8977139

Article Published Date : Dec 06, 1996

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Enzyme Inhibitors : CK(372) : AC(208)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin interferes with oligodendrocyte function, particularly the prior step in remyelination, indicating it may be harmful in demyelination diseases like MS.

Click here to read the entire abstract

Pubmed Data : J Neurosci Res. 2010 Nov 15 ;88(15):3361-75. PMID: 20857509

Article Published Date : Nov 15, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Demyelinating Diseases : CK(1278) : AC(250), Multiple Sclerosis : CK(716) : AC(133), Neuropathies : CK(450) : AC(67), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin treatment induces morphology alterations and cell death in mouse cochlear neuronal cells.

Click here to read the entire abstract

Pubmed Data : Acta Otolaryngol. 2009 Feb ;129(2):166-74. PMID: 18607908

Article Published Date : Feb 01, 2009

Study Type : In Vitro Study

Additional Links

Diseases : Cochlear Neuronal Damage : CK(1) : AC(1), DNA damage : CK(711) : AC(293), Hearing Disorders : CK(1) : AC(1), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin drugs have been identified to cause neuromyotoxicity.

Click here to read the entire abstract

Pubmed Data : Drugs Today (Barc). 2005 Apr ;41(4):267-93. PMID: 16034491

Article Published Date : Apr 01, 2005

Study Type : Review

Additional Links

Diseases : Neuromyotoxicity : CK(1) : AC(1)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79), Neurotoxic : CK(1076) : AC(179)

Statin drugs may intefere with neurological function in the brain by inhibiting cholesterol biosynthesis and synaptic transmission.

Click here to read the entire abstract

Pubmed Data : J Neurochem. 2011 Sep 7. Epub 2011 Sep 7. PMID: 21899539

Article Published Date : Sep 07, 2011

Study Type : Review

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Neurologic Disorders : CK(63) : AC(21), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statins have been associated with arrest of DNA synthesis and proliferation in glial cells.

Click here to read the entire abstract

Pubmed Data : J Neurochem. 1986 Apr ;46(4):1283-91. PMID: 3633306

Article Published Date : Apr 01, 1986

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

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