Oxidant

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View the Evidence: Adverse Pharmacological Actions

Astaxanthin protects smokers against oxidative stress.

Pubmed Data : J Med Food. 2011 Sep 1. Epub 2011 Sep 1. PMID: 21883001
Article Published Date : Sep 01, 2011
Study Type : Human Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Lipid Peroxidation : CK(403) : AC(127), Oxidative Stress : CK(1945) : AC(710), Smoking : CK(577) : AC(86)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Isoprostane Down-Regulation : CK(10) : AC(1), Malonaldehyde (MDA) Down-Regulation : CK(20) : AC(6), Superoxide Dismutase Up-regulation : CK(131) : AC(42)
Problem Substances : Tobacco: Smoking : CK(125) : AC(12)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Oxidant : CK(104) : AC(37)

Lovastatin enhances the susceptibility of LDL cholesterol to oxidation.

Pubmed Data : FEBS Lett. 1997 Jun 30;410(2-3):254-8. PMID: 9237640
Article Published Date : Jun 30, 1997
Study Type : Human Study
Additional Links
Diseases : Cholesterol: Oxidation : CK(457) : AC(98), Coronary Artery Disease : CK(1305) : AC(136), High Cholesterol : CK(1718) : AC(198)
Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Oxidant : CK(104) : AC(37)

Musclar side effects associated with statin drug use are related to oxidative stress.

Pubmed Data : J Clin Pharm Ther. 2001 Aug ;26(4):303-10. PMID: 11493374
Article Published Date : Aug 01, 2001
Study Type : Human Study
Additional Links
Diseases : Creatine Phosphokinase (CK): Elevated : CK(75) : AC(9), Isoprostane 8-epi-PGF2alpha: Elevated : CK(10) : AC(1), Myalgias : CK(105) : AC(14), Oxidative Stress : CK(1945) : AC(710), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79), Oxidant : CK(104) : AC(37)

Statin therapy appears to be associated with increased oxidation injury.

Pubmed Data : Drug Saf. 2002 ;25(12):877-83. PMID: 12241128
Article Published Date : Jan 01, 2002
Study Type : Human Study
Additional Links
Diseases : Oxidative Stress : CK(1945) : AC(710)
Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Vitamins B depletion, lower iron status and decreased antioxidative defense has been observed in patients with chronic hepatitis C treated by pegylated interferon alfa and ribavirin.

Pubmed Data : Clin Nutr. 2009 Feb;28(1):34-8. Epub 2008 Nov 29. PMID: 19042060
Article Published Date : Feb 01, 2009
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: B Complex : CK(30) : AC(3), Drug-Induced Nutrient Depletion: Iron : CK(30) : AC(3)
Additional Keywords : Drug-Nutrient Depletion : CK(64) : AC(7)
Problem Substances : Pegylated interferon alpha : CK(20) : AC(2), Ribavirin : CK(20) : AC(2)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Increased lipid peroxidation in a patient with CK-elevation and muscle pain during statin therapy has been reported.

Pubmed Data : Atherosclerosis. 2000 Nov ;153(1):255-6. PMID: 11058722
Article Published Date : Nov 01, 2000
Study Type : Human: Case Report
Additional Links
Diseases : Creatine Phosphokinase (CK): Elevated : CK(75) : AC(9), Lipid Peroxidation : CK(403) : AC(127), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

"Chronic nicotine toxicity is prevented by aqueous garlic extract."

Pubmed Data : Plant Foods Hum Nutr. 2005 Jun ;60(2):77-86. PMID: 16021835
Article Published Date : Jun 01, 2005
Study Type : Animal Study
Additional Links
Substances : Garlic : CK(485) : AC(160)
Diseases : Nicotine/Tobacco Toxicity : CK(152) : AC(26), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)
Problem Substances : Nicotine : CK(56) : AC(8)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

"Decreased in vitro fertility in male rats exposed to fluoride-induced oxidative stress damage and mitochondrial transmembrane potential loss."

Pubmed Data : Toxicol Appl Pharmacol. 2008 Aug 1 ;230(3):352-7. Epub 2008 Mar 28. PMID: 18455746
Article Published Date : Jul 31, 2008
Study Type : Animal Study
Additional Links
Diseases : Infertility: Male : CK(209) : AC(52), Oxidative Stress : CK(1945) : AC(710), Sperm Quality: Low : CK(162) : AC(28)
Problem Substances : Sodium Fluoride : CK(88) : AC(26)
Adverse Pharmacological Actions : Anti-Fertility : CK(6) : AC(1), Oxidant : CK(104) : AC(37)

Atorvastatin increases myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia.

Pubmed Data : J Card Surg. 2008 Jul-Aug;23(4):312-20. PMID: 18598320
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Endothelial Dysfunction : CK(897) : AC(173), High Cholesterol : CK(1718) : AC(198), Oxidative Stress : CK(1945) : AC(710)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Atorvastatin treatment reduces exercise capacities in rats and exacerbates metabolic perturbations and oxidative stress in skeletal muscle.

Pubmed Data : J Appl Physiol. 2011 Aug 18. Epub 2011 Aug 18. PMID: 21852406
Article Published Date : Aug 18, 2011
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress : CK(1945) : AC(710), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Celery extract protects against pesticide-induced toxicity.

Pubmed Data : Hum Exp Toxicol. 2011 Nov 1. Epub 2011 Nov 1. PMID: 22045891
Article Published Date : Nov 01, 2011
Study Type : Animal Study
Additional Links
Substances : Celery : CK(30) : AC(12), Flavonoids : CK(909) : AC(289)
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Pesticide-Induced Toxicity: Organophosphates : CK(17) : AC(6), Pesticide Toxicity : CK(147) : AC(45)
Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)
Problem Substances : Dichlorvos : CK(4) : AC(2), Organophosphates : CK(38) : AC(7), Pesticides : CK(699) : AC(70)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Oxidant : CK(104) : AC(37)

Fructose contributes to protein cross-linking.

Pubmed Data : Biochemistry. 1988 Mar 22;27(6):1901-7. PMID: 3132203
Article Published Date : Mar 22, 1988
Study Type : Animal Study
Additional Links
Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Glycation/A1C : CK(186) : AC(33), Glycation : CK(3) : AC(2)
Problem Substances : Fructose : CK(356) : AC(103)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Fructose-fed rats exhibit increased inflammation, fibrogenesis and NF-κB activation.

Pubmed Data : Eur J Pharmacol. 2011 Jun 17. Epub 2011 Jun 17. PMID: 21704028
Article Published Date : Jun 17, 2011
Study Type : Animal Study
Additional Links
Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Inflammation : CK(1077) : AC(363), Kidney Damage : CK(120) : AC(42), Kidney Diseases : CK(424) : AC(71), Kidney Fibrosis : CK(10) : AC(5)
Problem Substances : Fructose : CK(356) : AC(103)
Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Nephrotoxic : CK(162) : AC(38), NF-kappaB up-regulation : CK(3) : AC(2), Oxidant : CK(104) : AC(37), Profibrotic : CK(4) : AC(2)

L-thyroxine induces enhanced oxidative stress and oxygen consumption in the hyperthyroid rat liver.

Pubmed Data : Chem Biol Interact. 2008 May 28;173(2):105-14. Epub 2008 Mar 10. PMID: 18377885
Article Published Date : May 28, 2008
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress : CK(1945) : AC(710)
Problem Substances : Thyroxine : CK(104) : AC(15)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

L-thyroxine induces oxidative stress in the rat testicle.

Pubmed Data : Chem Biol Interact. 2008 Nov 25;176(2-3):121-8. Epub 2008 Aug 3. PMID: 18723006
Article Published Date : Nov 25, 2008
Study Type : Animal Study
Additional Links
Diseases : Drug-Induced Toxicity: L-Thyroxine : CK(23) : AC(8), Oxidative Stress : CK(1945) : AC(710)
Problem Substances : Thyroxine : CK(104) : AC(15)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Long term consumption of aspartame causes liver injury and oxidative stress in the rat liver.

Pubmed Data : Food Chem Toxicol. 2011 Jun ;49(6):1203-7. Epub 2011 Mar 3. PMID: 21376768
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Diseases : ALT: Elevated : CK(60) : AC(10), AST: Elevated : CK(26) : AC(4), Chemically-Induced Liver Damage : CK(475) : AC(175), Oxidative Stress : CK(1945) : AC(710)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Glutathione Down-Regulation : CK(4) : AC(2), Hepatotoxic : CK(283) : AC(80), Oxidant : CK(104) : AC(37)

Olive leaf extract ameliorates gentamicin nephrotoxicity via antioxidant activity, increase of renal glutathione content, and increase of renal antioxidant enzymes activity, except for glutathione peroxidase.

Pubmed Data : Iran J Kidney Dis. 2012 Jan ;6(1):25-32. PMID: 22218116
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract : CK(132) : AC(26)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(22) : AC(10)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Glutathione Upregulation : CK(144) : AC(48), Renoprotective : CK(191) : AC(90)
Problem Substances : Gentamicin : CK(2) : AC(1)
Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38), Oxidant : CK(104) : AC(37)

Olive leaf extract protects against the genetic and oxidative damage by permethrin in vivo.

Pubmed Data : Cytotechnology. 2012 Jan 20. Epub 2012 Jan 20. PMID: 22262123
Article Published Date : Jan 20, 2012
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract : CK(132) : AC(26)
Diseases : DNA damage : CK(711) : AC(293), Oxidative Stress : CK(1945) : AC(710), Pesticide Toxicity: Permethrin : CK(2) : AC(1)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Genoprotective : CK(116) : AC(48)
Problem Substances : Permethrin : CK(6) : AC(4)
Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61), Oxidant : CK(104) : AC(37)

Quercetin has a protective effect against sodium fluoride induced oxidative stress in rat's heart.

Pubmed Data : Food Funct. 2012 Feb 8. Epub 2012 Feb 8. PMID: 22314573
Article Published Date : Feb 08, 2012
Study Type : Animal Study
Additional Links
Substances : Quercetin : CK(318) : AC(136)
Diseases : Fluoride Toxicity : CK(146) : AC(40)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Cardioprotective : CK(702) : AC(196)
Problem Substances : Sodium Fluoride : CK(88) : AC(26)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Oxidant : CK(104) : AC(37)

Roundup causes oxidative stress in liver and inhibits acetylcholinesterase in muscle and brain of a neotropical fish.

Pubmed Data : Chemosphere. 2010 Jan;78(3):294-9. Epub 2009 Nov 11. PMID: 19910015
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Additional Keywords : Environmental Pollutant : CK(32) : AC(15)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Hepatotoxic : CK(283) : AC(80), Neurotoxic : CK(1076) : AC(179), Oxidant : CK(104) : AC(37)

Sesamol protects against acetaminophen-induced injury in animals.

Pubmed Data : Shock. 2009 Jul ;32(1):89-93. PMID: 18948843
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol : CK(79) : AC(30)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Chemically-Induced Liver Damage : CK(475) : AC(175), Lipid Peroxidation : CK(403) : AC(127), Liver Damage : CK(597) : AC(213), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)
Problem Substances : Tylenol : CK(125) : AC(13)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Oxidant : CK(104) : AC(37)

Sodium fluoride produces alterations in erythrocytes of the male rat through increased oxidative stress.

Pubmed Data : Int J Mol Sci. 2010;11(6):2443-52. Epub 2010 Jun 11. PMID: 20640162
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Problem Substances : Sodium Fluoride : CK(88) : AC(26)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

The developmental and reproductive toxicity observed in animals given tamoxifen may be due to the oxidative stress it induces.

Pubmed Data : Life Sci. 2001 Mar 2;68(15):1735-49. PMID: 11270620
Article Published Date : Mar 02, 2001
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress : CK(1945) : AC(710)
Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)
Problem Substances : Tamoxifen : CK(319) : AC(39)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Titanium dioxide causes oxidative stress responses in the water flea (Daphnia magna) in a particle-size dependent fashion.

Pubmed Data : Sci Total Environ. 2010 Feb 13. Epub 2010 Feb 13. PMID: 20153877
Article Published Date : Feb 13, 2010
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress : CK(1945) : AC(710)
Problem Substances : Titanium Dioxide : CK(41) : AC(17)
Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Vitamin E protects against oxidative and neurological damage caused by formaldehyde.

Pubmed Data : J Chem Neuroanat. 2005 May ;29(3):173-8. PMID: 15820619
Article Published Date : May 01, 2005
Study Type : Animal Study
Additional Links
Substances : Vitamin E : CK(1285) : AC(221)
Diseases : Brain Damage : CK(89) : AC(41), Formaldehyde Toxicity : CK(4) : AC(2), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Malondialdehyde Down-regulation : CK(76) : AC(21), Neuroprotective Agents : CK(962) : AC(480), Superoxide Dismutase Up-regulation : CK(131) : AC(42)
Problem Substances : Formaldehyde : CK(19) : AC(10)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179), Oxidant : CK(104) : AC(37)

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