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Additional Topics Details for this Page
Article Count
- 9
Cumulative Knowledge
- 68
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Quick Summary: Current access displays 2 out of 6 associated Problem Substances
Name
Cumulative Knowledge
Article Count
Focus Articles
Alendronate (trade name Fosamax)
63
8
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Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
30
3
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Quick Summary: Current access displays 2 out of 10 associated Diseases
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Gastric Ulcer
55
7
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Drug-Induced Toxicity: Gastrointestinal
20
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View the Evidence: Adverse Pharmacological Actions
Alendronate and naproxen are synergistic for development of gastric ulcers.
Click here to read the entire abstract
Pubmed Data
: Arch Intern Med. 2001 Jan 8;161(1):107-10. PMID:
11146706
Article Published Date
: Jan 08, 2001
Study Type
: Human Study
Additional Links
Diseases
:
Duodenal Ulcer : CK(89) : AC(26)
,
Gastric Ulcer : CK(246) : AC(91)
Additional Keywords
:
Toxic Drug Synergy : CK(10) : AC(1)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
,
Naproxen : CK(54) : AC(7)
,
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)
Adverse Pharmacological Actions
:
Ulcerogenic : CK(66) : AC(9)
Alendronate has been associated with esophageal injury in users.
Click here to read the entire abstract
Pubmed Data
: Mod Pathol. 1999 Dec;12(12):1152-7. PMID:
10619269
Article Published Date
: Dec 01, 1999
Study Type
: Human Study
Additional Links
Diseases
:
Esophageal Cancer : CK(328) : AC(55)
,
Gastric Ulcer : CK(246) : AC(91)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
Adverse Pharmacological Actions
:
Ulcerogenic : CK(66) : AC(9)
Alendronate is associated with injury and ulceration of the gastric mucosa.
Click here to read the entire abstract
Pubmed Data
: Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID:
11069316
Article Published Date
: Nov 01, 2000
Study Type
: Human Study
Additional Links
Diseases
:
Drug-Induced Toxicity: Gastrointestinal : CK(21) : AC(3)
,
Gastric Ulcer : CK(246) : AC(91)
,
Osteoporosis : CK(1171) : AC(205)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
,
Aspirin : CK(471) : AC(64)
,
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)
Adverse Pharmacological Actions
:
Gastrotoxic : CK(20) : AC(2)
,
Ulcerogenic : CK(66) : AC(9)
Alendronate users have an increased rate of esophageal and gastric events.
Click here to read the entire abstract
Pubmed Data
: Pharmacoepidemiol Drug Saf. 2000 Sep;9(5):371-6. PMID:
19025842
Article Published Date
: Sep 01, 2000
Study Type
: Human Study
Additional Links
Diseases
:
Esophageal Diseases : CK(10) : AC(1)
,
Gastric Ulcer : CK(246) : AC(91)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
Adverse Pharmacological Actions
:
Ulcerogenic : CK(66) : AC(9)
Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.
Click here to read the entire abstract
Pubmed Data
: Am J Gastroenterol. 1997 Aug;92(8):1322-5. PMID:
9260798
Article Published Date
: Aug 01, 1997
Study Type
: Human Study
Additional Links
Diseases
:
Drug-Induced Toxicity: Gastrointestinal : CK(21) : AC(3)
,
Gastric Ulcer : CK(246) : AC(91)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
,
Aspirin : CK(471) : AC(64)
,
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)
,
Pamidronate : CK(33) : AC(6)
Adverse Pharmacological Actions
:
Gastrotoxic : CK(20) : AC(2)
,
Ulcerogenic : CK(66) : AC(9)
Esophagitis associated with use of alendronate has been reported in postmenopausic patients.
Click here to read the entire abstract
Pubmed Data
: Acta Gastroenterol Latinoam. 2001 May;31(2):59-63. PMID:
11471319
Article Published Date
: May 01, 2001
Study Type
: Human Study
Additional Links
Diseases
:
Esophagitis : CK(12) : AC(2)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
Adverse Pharmacological Actions
:
Corrosive : CK(10) : AC(1)
,
Ulcerogenic : CK(66) : AC(9)
Atorvastatin-induced severe gastric ulceration has been reported.
Click here to read the entire abstract
Pubmed Data
: World J Gastroenterol. 2005 May 28 ;11(20):3159-60. PMID:
15918210
Article Published Date
: May 28, 2005
Study Type
: Human: Case Report
Additional Links
Diseases
:
Gastric Ulcer : CK(246) : AC(91)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
Adverse Pharmacological Actions
:
Ulcerogenic : CK(66) : AC(9)
Alendronate is used experimentally to induce gastric damage and lesion in rat stomachs.
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2007 Oct;15(5):196-202. PMID:
17943251
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Diseases
:
Gastric Ulcer : CK(246) : AC(91)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
Adverse Pharmacological Actions
:
Ulcerogenic : CK(66) : AC(9)
Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID:
21084063
Article Published Date
: Jan 31, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Fucoidan : CK(152) : AC(72)
Diseases
:
Aspirin-Induced Toxicity : CK(83) : AC(24)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
,
Cyclooxygenase 1 Inhibitor : CK(22) : AC(18)
,
Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)
,
Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)
Problem Substances
:
Aspirin : CK(471) : AC(64)
Adverse Pharmacological Actions
:
Ulcerogenic : CK(66) : AC(9)
Alendoronate has been reported to cause esophageal ulceration.
Click here to read the entire abstract
Pubmed Data
: Arq Gastroenterol. 2001 Apr-Jun;38(2):129-31. PMID:
11793943
Article Published Date
: Apr 01, 2001
Study Type
: Commentary
Additional Links
Diseases
:
Esophageal Ulcer : CK(1) : AC(1)
,
Gastric Cancer : CK(373) : AC(111)
,
Osteoporosis : CK(1171) : AC(205)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
Adverse Pharmacological Actions
:
Ulcerogenic : CK(66) : AC(9)
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