Chemotherapy

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View the Evidence: Problematic Actions

There are high rates of behavioral symptoms in breast cancer survivors, particularly those treated with chemotherapy

Pubmed Data : J Clin Oncol. 2011 Aug 8. Epub 2011 Aug 8. PMID: 21825266
Article Published Date : Aug 08, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Depression : CK(674) : AC(88), Fatigue : CK(194) : AC(30), Inflammation : CK(1077) : AC(363), Insomnia : CK(471) : AC(56)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)
Problem Substances : Chemotherapy : CK(348) : AC(44)
Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Tumor necrosis factorα (TNFα) up-regulation : CK(42) : AC(4)

Astragalus may provide an ideal complementary treatment to chemotherapy.

Pubmed Data : Food Chem Toxicol. 2008 Mar;46(3):1089-96. Epub 2007 Nov 17. PMID: 12592686
Article Published Date : Mar 01, 2008
Study Type : Human Study
Additional Links
Substances : Astragalus : CK(225) : AC(49)
Diseases : Chemotherapy : CK(65) : AC(16), Chemotherapy-Induced Toxicity : CK(704) : AC(184)

Bi-weekly administration of paclitaxel and cisplatin in patients with advanced esophageal cancer results in amedian survival for all patients of 9 months.

Pubmed Data : Br J Cancer. 2002 Mar 4;86(5):669-73. PMID: 11875723
Article Published Date : Mar 04, 2002
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Esophageal Cancer : CK(328) : AC(55)
Additional Keywords : Drug: Cisplatin : CK(31) : AC(11), Drug: Paclitaxel : CK(36) : AC(13)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Biweekly oxaliplatin and irinotecan chemotherapy in advanced gastric cancer results in a median overall survival time of 9.5 months.

Pubmed Data : Anticancer Res. 2008 Sep-Oct;28(5B):2901-5. PMID: 19031932
Article Published Date : Sep 01, 2008
Study Type : Human Study
Additional Links
Diseases : Gastric Cancer : CK(373) : AC(111)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)
Problem Substances : Chemotherapy : CK(348) : AC(44), Irinotecan : CK(30) : AC(3), Oxaliplatin : CK(30) : AC(3)

Cannabis extract is safe and efficacious in reducing chemotherapy-induced nauseau and vomiting.

Pubmed Data : Br J Clin Pharmacol. 2010 Nov;70(5):656-63. PMID: 21039759
Article Published Date : Nov 01, 2010
Study Type : Human Study
Additional Links
Substances : Cannabis : CK(738) : AC(132)
Diseases : Chemotherapy : CK(65) : AC(16), Chemotherapy-Induced Toxicity : CK(704) : AC(184), Naseau: Chemotherapy-Induced : CK(70) : AC(6)
Pharmacological Actions : Antiemetics : CK(40) : AC(4)

Carnitine improves fatigue, quality of life, lean body mass and appetite in advanced cancer patients undergoing anticancer therapy.

Pubmed Data : Nutrition. 2006 Feb;22(2):136-45. PMID: 16459226
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Substances : Carnitine : CK(672) : AC(69)
Diseases : Cancers: All : CK(9062) : AC(2869), Chemotherapy : CK(65) : AC(16), Chemotherapy-Induced Toxicity : CK(704) : AC(184), Fatigue : CK(194) : AC(30), Quality of Life: Poor : CK(170) : AC(16)
Additional Keywords : Antineoplastic Agents : CK(69) : AC(28), Drug Side Effect Attenuation : CK(252) : AC(49)

Carnitine improves fatigue, sleep quality, depression in advanced patients.

Pubmed Data : J Pain Symptom Manage. 2006 Dec;32(6):551-9. PMID: 17157757
Article Published Date : Dec 01, 2006
Study Type : Human Study
Additional Links
Substances : Carnitine : CK(672) : AC(69)
Diseases : Chemotherapy : CK(65) : AC(16), Fatigue : CK(194) : AC(30)
Additional Keywords : Drug Side Effect Attenuation : CK(252) : AC(49)

Chemotherapeutic agents may induce hypersensitivity reactions in pediatric patients.

Pubmed Data : Asian Pac J Allergy Immunol. 2009 Dec;27(4):191-7. PMID: 20232573
Article Published Date : Dec 01, 2009
Study Type : Human Study
Additional Links
Diseases : Hypersensitivity : CK(64) : AC(15), Urticaria : CK(130) : AC(8)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Chemotherapy does not appear to provide any benefit for metastatic cancer of the esophagus and gasto-esophageal junction.

Pubmed Data : Cochrane Database Syst Rev. 2010;5:CD004063. Epub 2010 May 12. PMID: 20464727
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Esophageal Cancer : CK(328) : AC(55), Gastrointestinal Cancer : CK(43) : AC(11)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Chemotherapy for pancreatic cancer results in median survival and 1-year survival times of 4.9 months (95% CI, 4.5 to 5.6) and 16% for GEM, 6.2 months (95% CI, 5.4 to 6.9), and 21% for GEM FDR, and 5.7 months (95% CI, 4.9 to 6.5) and 21% for GEMOX.

Pubmed Data : J Clin Oncol. 2009 Aug 10;27(23):3778-85. Epub 2009 Jul 6. PMID: 19581537
Article Published Date : Aug 10, 2009
Study Type : Human Study
Additional Links
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Chemotherapy used in advanced gastric or gastroesophageal adenocarcinoma results in an overall median survival time of between 7-9 months.

Pubmed Data : J Clin Oncol. 2010 Mar 20;28(9):1547-53. Epub 2010 Feb 16. PMID: 20159816
Article Published Date : Mar 20, 2010
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Esophageal Cancer : CK(328) : AC(55), Gastric Cancer : CK(373) : AC(111)
Additional Keywords : Chemotherapy : CK(20) : AC(2), Drug: 5-flourouracil : CK(88) : AC(22)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Chemotherapy with gemcitabine results in median progression-free survival (PFS) and overall survival (OS) times for the entire population were 4.4 months (95% confidence interval [CI], 3.5-5.1 months) and 7.7 months (95% CI, 6.3-8.8 months), respectively,

Pubmed Data : Oncologist. 2010;15(2):e1-4. PMID: 20189980
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Chemotherapy, but not a specific chemotherapy regimen, was associated with an increased risk of stroke.

Pubmed Data : Free Radic Res. 2002 Apr;36(4):455-60. PMID: 15494603
Article Published Date : Apr 01, 2002
Study Type : Human Study
Additional Links
Diseases : Stroke : CK(540) : AC(47)
Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Combination chemotherapy and chemoradiation does not improve overall survival in inoperabe advanced pancreatic cancer over single chemotherapy alone.

Pubmed Data : Cochrane Database Syst Rev. 2009(4):CD002093. Epub 2009 Oct 7. PMID: 19821291
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)
Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Drug: Gemcitabine : CK(36) : AC(13)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

FOLFIRI and FOLFOX6 chemotherapies result in a median progression free survival time of between 7.7 and 8.4 months.

Pubmed Data : Jpn J Clin Oncol. 2010 Jul;40(7):634-8. PMID: 20587616
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115)
Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma.

Pubmed Data : Ann Oncol. 2008 Jul ;19(7):1327-30. Epub 2008 Mar 17. PMID: 18349031
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Lymphoma: Mantle Cell : CK(35) : AC(8)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)
Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)
Problem Substances : Chemotherapy : CK(348) : AC(44)

Memory deficits occur in breast cancer patients who receive either chemotherapy or tamoxifen.

Pubmed Data : J Psychosoc Oncol. 2011 Sep-Oct;29(5):499-514. PMID: 21882931
Article Published Date : Sep 01, 2011
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Memory Disorders: Drug-Induced : CK(77) : AC(12), Memory Loss : CK(113) : AC(32)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)
Problem Substances : Tamoxifen : CK(319) : AC(39)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Pycnogenol may alleviate adverse effects in oncologic treatment, e.g. deep vein thrombosis.

Pubmed Data : Mol Vis. 2008;14:1288-92. Epub 2008 Jul 10. PMID: 18927527
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289), Pycnogenol (Pine Bark) : CK(385) : AC(61)
Diseases : Chemotherapy : CK(65) : AC(16), Deep Vein Thrombosis : CK(511) : AC(10), Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)
Additional Keywords : Drug Side Effect Attenuation : CK(252) : AC(49)

Radiation and chemotherapy may increase tumour-initiating cell activity in triple-negative breast cancer.

Pubmed Data : Expert Rev Mol Med. 2010;12:e22. Epub 2010 Jul 26. PMID: 20653987
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Breast Cancer: Triple Negative : CK(61) : AC(13)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38), Radiotherapy : CK(342) : AC(55)

Tamoxifen and raloxifene adversely affect cognitive function in older women.

Pubmed Data : J Womens Health (Larchmt). 2010 Mar ;19(3):371-9. PMID: 20136553
Article Published Date : Mar 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)
Problem Substances : Raloxifene : CK(103) : AC(11), Tamoxifen : CK(319) : AC(39)

The median overall survival time for oxaliplatin, irinotecan and cetuximab treatment in advanced gastric cancer is survival was 38.1 weeks.

Pubmed Data : Anticancer Res. 2011 Dec ;31(12):4439-43. PMID: 22199312
Article Published Date : Dec 01, 2011
Study Type : Human Study
Additional Links
Diseases : Gastric Cancer : CK(373) : AC(111)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)
Problem Substances : Cetuximab : CK(10) : AC(1), Chemotherapy : CK(348) : AC(44), Irinotecan : CK(30) : AC(3), Oxaliplatin : CK(30) : AC(3)

Therapy-related acute myeloid leukemia and myelodysplastic syndrome has been reported.

Pubmed Data : J Med Food. 2005 Fall;8(3):382-5. PMID: 3857944
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide : CK(27) : AC(10), Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28), Lymphoma : CK(209) : AC(69), Myelodysplastic Syndrome : CK(198) : AC(18), Radiation Induced Illness : CK(1018) : AC(249)
Additional Keywords : Iatrogenic Disease : CK(226) : AC(26)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38), Radiotherapy : CK(342) : AC(55)

"Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy."

Pubmed Data : Clin Cancer Res. 2012 Feb 14. Epub 2012 Feb 14. PMID: 22338017
Article Published Date : Feb 14, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain Injury: Hippocampal Damage : CK(35) : AC(16), Chemotherapy-Induced Toxicity : CK(704) : AC(184), Chemotherapy-Induced Toxicity: Doxorubicin : CK(59) : AC(25), Cognitive Decline/Dysfunction : CK(522) : AC(87)
Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)
Problem Substances : Cyclophosphamide : CK(2) : AC(1), Doxorubicin : CK(6) : AC(3)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.

Pubmed Data : Int J Cancer. 2010 Sep 13. Epub 2010 Sep 13. PMID: 20839263
Article Published Date : Sep 13, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Chemotherapy : CK(65) : AC(16), Colorectal Cancer : CK(877) : AC(321)
Pharmacological Actions : Chemosensitizer : CK(197) : AC(159)
Additional Keywords : Drug: Oxaliplatin : CK(6) : AC(5), Drug Synergy : CK(327) : AC(147)

Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation.

Pubmed Data : PLoS One. 2010;5(10):e13264. Epub 2010 Oct 11. PMID: 20845461
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Chemotherapy : CK(65) : AC(16), Ovarian Cancer : CK(154) : AC(58)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)
Additional Keywords : Drug: Paclitaxel : CK(36) : AC(13), Drug Synergy : CK(327) : AC(147)

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