Nocebo Effect

Nocebo Effect

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Article Count - 10
Cumulative Knowledge - 93

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Cumulative Knowledge is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.

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Quick Summary: 9 associated Diseases

Name	Cumulative Knowledge	Article Count	Focus Articles
Hyperalgesia	21	3	Log in \| Sign up
Cesarean Section	10	1	Log in \| Sign up
Common Cold	10	1	Log in \| Sign up
Irritable Bowel Syndrome	10	1	Log in \| Sign up
Itching	10	1	Log in \| Sign up
Pain	10	1	Log in \| Sign up
Suicidal Behavior	10	1	Log in \| Sign up
Multiple Sclerosis	1	1	Log in \| Sign up
Prenatal Chemical Exposures	1	1	Log in \| Sign up

View the Evidence: Problematic Actions

"No One Sees the Fear: Becoming Diseased Before Becoming Ill-Being Diagnosed With Breast Cancer."

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Pubmed Data : Cancer Nurs. 2013 Feb 28. Epub 2013 Feb 28. PMID: 23448954

Article Published Date : Feb 27, 2013

Study Type : Human Study

Additional Links

Diseases : Breast Cancer: Diagnosis : CK(30) : AC(3)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10), Stress : CK(30) : AC(9)

A doctor's posture posture, permeated by positive or negative manifestations (comments, suggestions, attitudes etc.), can result in both favorable and unfavorable effects in their patients.

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Pubmed Data : Rev Assoc Med Bras. 2009 Jan-Feb;55(1):13-8. PMID: 19360271

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

Clinician empathy reduces the duration and severity of the common cold in patients.

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Pubmed Data : Fam Med. 2009 Jul-Aug;41(7):494-501. PMID: 19582635

Article Published Date : Jul 01, 2009

Study Type : Human Study

Additional Links

Diseases : Common Cold : CK(473) : AC(56)

Therapeutic Actions : Empathy : CK(20) : AC(2), Placebo Effect : CK(70) : AC(6)

Pharmacological Actions : Interleukin-8 upregulation : CK(20) : AC(2)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

Fear-driven cesarean section on request; 52% of elective requests are avoided following education on pharmacological and non-pharmacological ways of avoiding labor pain.

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Pubmed Data : Pol Merkur Lekarski. 2012 Aug ;33(194):86-9. PMID: 23009005

Article Published Date : Jul 31, 2012

Study Type : Human Study

Additional Links

Diseases : Cesarean Section : CK(431) : AC(33)

Therapeutic Actions : Acupuncture : CK(1294) : AC(147)

Anti Therapeutic Actions : Cesarean Delivery : CK(633) : AC(43), Nocebo Effect : CK(73) : AC(10)

Induction of nocebo and placebo effects on itch and pain by verbal suggestions.

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Pubmed Data : Pain. 2011 Jul;152(7):1486-94. Epub 2011 Feb 24. PMID: 21353388

Article Published Date : Jul 01, 2011

Study Type : Human Study

Additional Links

Diseases : Itching : CK(45) : AC(5), Pain : CK(616) : AC(91)

Therapeutic Actions : Placebo Effect : CK(70) : AC(6)

Additional Keywords : Iatrogenic Disease : CK(226) : AC(26)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

More than two-thirds of an unselected sample of 34 college students reported mild headaches when told that a (nonexistent) electric current was passing through their heads.

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Pubmed Data : Pavlov J Biol Sci. 1981 Jul-Sep;16(3):140-3. PMID: 7290754

Article Published Date : Jun 30, 1981

Study Type : Human Study

Additional Links

Diseases : Anxiety Disorders : CK(659) : AC(82), Pain : CK(616) : AC(91)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

Nocebo-induced hyperalgesia during local anesthetic injection.

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Pubmed Data : Anesth Analg. 2010 Mar 1;110(3):868-70. Epub 2009 Dec 30. PMID: 20042440

Article Published Date : Mar 01, 2010

Study Type : Human Study

Additional Links

Diseases : Hyperalgesia : CK(35) : AC(10)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

Suicide and cardiovascular death after a cancer diagnosis is greatly increased.

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Pubmed Data : N Engl J Med. 2012 Apr 5 ;366(14):1310-8. PMID: 22475594

Article Published Date : Apr 05, 2012

Study Type : Human Study

Additional Links

Diseases : Suicidal Behavior : CK(83) : AC(10)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors.

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Pubmed Data : Neuroimage. 2009 Sep;47(3):995-1001. Epub 2009 Apr 16. PMID: 19375508

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Hyperalgesia : CK(35) : AC(10), Irritable Bowel Syndrome : CK(829) : AC(66)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

The apparent permeability across placental cells grown on polycarbonate membranes (3.0μm pore size) was four times higher for the 50 nm particles compared with the 100 nm particles.

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Pubmed Data : Int J Nanomedicine. 2012 ;7:497-510. Epub 2012 Jan 31. PMID: 22334780

Article Published Date : Jan 01, 2012

Study Type : In Vitro Study

Additional Links

Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

The nocebo effect in multiple sclerosis trials are substantial and appear to have increased significantly in recent years .

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Pubmed Data : Mult Scler. 2010 Jul;16(7):816-28. Epub 2010 Jun 10. PMID: 20538704

Article Published Date : Jul 01, 2010

Study Type : Review

Additional Links

Diseases : Multiple Sclerosis : CK(716) : AC(133)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

There are neurobiological mechanisms that may explain the hyperanalgesic consequences of the nocebo effect.

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Pubmed Data : Neuroscience. 2007 Jun 29;147(2):260-71. Epub 2007 Mar 26. PMID: 17379417

Article Published Date : Jun 29, 2007

Study Type : Commentary

Additional Links

Diseases : Hyperalgesia : CK(35) : AC(10)

Anti Therapeutic Actions : Nocebo Effect : CK(73) : AC(10)

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Placebos, Nocebos, and the Symptoms of Healing

Written by Tracy Kolenchuk

The placebo effect is one of the most misunderstood, misrepresented, misused and maligned effects of health and medical products.

Research: Some Cancer Diagnoses Kill Quicker Than The Cancer

Written by Sayer Ji, Founder

New research now indicates that a cancer diagnosis may be as fatal as the cancer itself, dramatically increasing the risk of suicide and heart-related death in the week following diagnosis. The risk of suicide was found to be 16 times higher and the risk of heart-related death 26 times higher during the first week following diagnosis versus those who were cancer free.

Does Conventional Medical Training Destroy Empathy?

Written by Sayer Ji, Founder

A surprisingly consistent body of research exists indicating that conventional medical training actually reduces practitioner empathy. What is worse, the decline in empathy appears even more pronounced at the time that the curriculum shifts towards patient-care activities.

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