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Abstract Title:

Low-Dose Bisphenol A Activates Cyp11a1 Gene Expression and Corticosterone Secretion in Adrenal Gland via the JNK Signaling Pathway.

Abstract Source:

Toxicol Sci. 2015 Jul 25. Epub 2015 Jul 25. PMID: 26209791

Abstract Author(s):

Hsin-Chieh Lan, I-Wen Lin, Zhi-Jie Yang, Jyun-Hong Lin

Article Affiliation:

Hsin-Chieh Lan

Abstract:

Certain commonly used compounds that interfere with the functions of the endocrine system are classified as endocrine-disrupting chemicals (EDCs). Bisphenol A (BPA) is an EDC that is widely used in food containers. BPA levels in human sera are commonly observed to be approximately 1 to 100 nM. Compared to the effects of BPA on the gonads, its effects on the adrenal gland are poorly understood. To investigate the influence of BPA on steroidogenesis, we examined the activity of the steroidogenic gene Cyp11a1 and its regulatory pathways in mouse Y1 adrenal cortex cells. Treatment with BPA at<100μM did not cause cell death. However, increased promoter activity and protein expression of Cyp11a1 were induced by low doses of BPA (10-1000 nM). Moreover, BPA induced c-Jun phosphorylation, and a specific inhibitor of c-Jun N-terminal kinase (JNK) significantly suppressed BPA-induced steroidogenesis. Thus, treatment of adrenal cells with low doses of BPA activated Cyp11a1 and increased corticosterone production through the JNK/c-Jun signaling pathway. Identical results were observed in rats after BPA injection. The abnormal induction of hormone synthesis by BPA in the adrenal gland might belinked to human metabolic defects and neuropsychiatric disorders.

Study Type : Animal Study
Additional Links
Additional Keywords : Risk Factors : CK(3057) : AC(392)
Problem Substances : Bisphenol A : CK(685) : AC(178)

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Sayer Ji
Founder of GreenMedInfo.com

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