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Abstract Title:

Acute cholestatic hepatitis associated with pravastatin.

Abstract Source:

Am J Gastroenterol. 1999 May ;94(5):1388-90. PMID: 10235223

Abstract Author(s):

M Hartleb, G Rymarczyk, K Januszewski

Article Affiliation:

Department of Gastroenterology, Silesian Medical School, Katowice, Poland.

Abstract:

A 57-yr-old man presented with clinical and laboratory signs of acute cholestatic hepatitis. Symptoms had appeared 7 wk after he was started on pravastatin 20 mg/day for hypercholesterolemia. A full evaluation including ultrasound, computed tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic nonobstructive jaundice. The liver function abnormalities normalized 7 wk after cessation of therapy. Pravastatin should be considered as a potential cause of cholestatic hepatitis with favorable clinical outcome after drug withdrawal.

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Sayer Ji
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