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Abstract Title:

The effect of coenzyme Q10 in statin myopathy.

Abstract Source:

Neuro Endocrinol Lett. 2012 Nov 28 ;33(Suppl2):98-101. Epub 2012 Nov 28. PMID: 23183519

Abstract Author(s):

Lukas Zlatohlavek, Michal Vrablik, Barbora Grauova, Eva Motykova, Richard Ceska

Article Affiliation:

3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University and General Teaching Hospital Prague, Czech Republic. lukas.zlatohlavek@lf1.cuni.cz.

Abstract:

OBJECTIVES: Statins significantly reduce CV morbidity and mortality. Unfortunately, one of the side effects of statins is myopathy, for which statins cannot be administered in sufficient doses or administered at all. The aim of this study was to demonstrate the effect of coenzyme Q10 in patients with statin myopathy. DESIGN/SETTING: Twenty eight patients aged 60.6±10.7 years were monitored (18 women and 10 men) and treated with different types and doses of statin. Muscle weakness and pain was monitored using a scale of one to ten, on which patients expressed the degree of their inconvenience. Examination of muscle problems was performed prior to administration of CQ10 and after 3 and 6 months of dosing. Statistical analysis was performed using Friedman test, Annova and Students t-test. RESULTS: Pain decreased on average by 53.8% (p<0.0001), muscle weakness by 44.4% (p<0.0001). The CQ10 levels were increased by more than 194% (from 0,903μg/ml to 2.66 μg/ml; p<0.0001). CONCLUSION: After a six-month administration of coenzyme Q10, muscle pain and sensitivity statistically significantly decreased.

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