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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats.

Abstract Source:

Molecules. 2016 Oct 26 ;21(11). Epub 2016 Aug 26. PMID: 27792195

Abstract Author(s):

Israel Pérez-Torres, Juan Carlos Torres-Narváez, José Pedraza-Chaverri, María Esther Rubio-Ruiz, Eulises Díaz-Díaz, Leonardo Del Valle-Mondragón, Raúl Martínez-Memije, Elvira Varela López, Verónica Guarner-Lans

Article Affiliation:

Israel Pérez-Torres

Abstract:

The antioxidant properties of aged garlic extract (AGE) on cardiovascular functioning (CF) in metabolic syndrome (MS) remains poorly studied. Here we study the AGE effects on CF in a rat model of MS. Control rats plus saline solution (C + SS), MS rats (30% sucrose in drinking water from weaning) plus saline solution (MS + SS), control rats receiving AGE (C + AGE 125 mg/Kg/12 h) and MS rats with AGE (MS + AGE) were studied. MS + SS had increased triglycerides, systolic blood pressure, insulin, leptin, HOMA index, and advanced glycation end products. AGE returned their levels to control values (p<0.01). Cholesterol was decreased by AGE (p = 0.05). Glutathion and GPx activity were reduced in MS + SS rats and increased with AGE (p = 0.05). Lipid peroxidation was increased in MS + SS and AGE reduced it (p = 0.001). Vascular functioning was deteriorated by MS (increased vasocontraction and reduced vasodilation) and AGE improved it (p = 0.001). Coronary vascular resistance was increased in MS rats and AGE decreased it (p = 0.001). Cardiac performance was not modified by MS but AGE increased it. NO measured in the perfusate liquid from the heart and serum citrulline, nitrites/nitrates were decreased in MS and AGE increased them (p<0.01). In conclusion, AGE reduces MS-induced cardiovascular risk, through its anti-oxidant properties.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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