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Aloe has an antileukaemic effect. - GreenMedInfo Summary

Abstract Title:

Induction of apoptosis in human leukaemic cell lines K562, HL60 and U937 by diethylhexylphthalate isolated from Aloe vera Linne.

Abstract Source:

J Pharm Pharmacol. 2000 Aug;52(8):1037-41. PMID: 11007077

Abstract Author(s):

K H Lee, H S Hong, C H Lee, C H Kim

Abstract:

We investigated the effect of diethylhexylphthalate (DEHP) from Aloe vera Linne pharmacological activity. At a level of 10 microg mL(-1) DEHP a significant anti-leukaemic effect was observed for all three cell lines, as measured by clonogenic assay. After treatment with 10 microg mL(-1) DEHP for 4 h, agarose gel electrophoresis and flow cytometric analysis confirmed the occurrence of apoptosis. These results indicate that DEHP isolated from Aloe vera Linne has a potent antileukaemic effect, and thus represents a new type of pharmacological activity with respect to human leukaemic cells.

Study Type : In Vitro Study
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Sayer Ji
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