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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

α-Lipoic Acid Reduces Iron-induced Toxicity and Oxidative Stress in a Model of Iron Overload.

Abstract Source:

Int J Mol Sci. 2019 Jan 31 ;20(3). Epub 2019 Jan 31. PMID: 30708965

Abstract Author(s):

Giuseppina Camiolo, Daniele Tibullo, Cesarina Giallongo, Alessandra Romano, Nunziatina L Parrinello, Giuseppe Musumeci, Michelino Di Rosa, Nunzio Vicario, Maria V Brundo, Francesco Amenta, Margherita Ferrante, Chiara Copat, Roberto Avola, Giovanni Li Volti, Antonio Salvaggio, Francesco Di Raimondo, Giuseppe A Palumbo

Article Affiliation:

Giuseppina Camiolo

Abstract:

Iron toxicity is associated with organ injury and has been reported in various clinical conditions, such as hemochromatosis, thalassemia major, and myelodysplastic syndromes. Therefore, iron chelation therapy represents a pivotal therapy for these patients during their lifetime. The aim of the present study was to assess the iron chelating properties ofα-lipoic acid (ALA) and how such an effect impacts on iron overload mediated toxicity. Human mesenchymal stem cells (HS-5) and animals (zebrafish,= 10 for each group) were treated for 24 h with ferric ammonium citrate (FAC, 120µg/mL) in the presence or absence of ALA (20 µg/mL). Oxidative stress was evaluated by reduced glutathione content, reactive oxygen species formation, mitochondrial dysfunction, and gene expression of heme oxygenase-1b and mitochondrial superoxide dismutase; organ injury, iron accumulation, and autophagy were measured by microscopical, cytofluorimetric analyses, and inductively coupled plasma‒optical mission Spectrometer (ICP-OES). Our results showed that FAC results in a significant increase of tissue iron accumulation, oxidative stress, and autophagy and such detrimental effects were reversed by ALA treatment. In conclusion, ALA possesses excellent iron chelating properties that may be exploited in a clinical setting for organ preservation, as well as exhibiting a good safety profile and low cost for the national health system.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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