Alpinia glanga inhibits an HIV-1 viral regulatory protein, in vitro. - GreenMedInfo Summary
New Rev-export inhibitor from Alpinia galanga and structure-activity relationship.
Bioorg Med Chem Lett. 2009 May 1;19(9):2555-7. Epub 2009 Mar 17. PMID: 19342232
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
Bioassay-guided separation by use of the fission yeast expressing NES of Rev, an HIV-1 viral regulatory protein, disclosed 1'-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga. Both analysis for mechanism of action with biotinylated probe (2) and several synthesized analogs established crucial portions in 1 for Rev-export inhibitory activity.