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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Alteration of mammary gland development by bisphenol a and evidence of a mode of action mediated through endocrine disruption.

Abstract Source:

Mol Cell Endocrinol. 2018 Jul 23. Epub 2018 Jul 23. PMID: 30048677

Abstract Author(s):

Martine Perrot-Applanat, Martine Kolf-Clauw, Cécile Michel, Claire Beausoleil

Article Affiliation:

Martine Perrot-Applanat

Abstract:

The development and function of the mammary gland are endocrine-dependent processes, depending on the stage of development. Foetal and/or postnatal exposure to low doses of BPA alters tissue organisation through epithelial proliferation and stroma-epithelial interactions. BPA also alters the expression of E2-dependent epithelial and stroma transcriptomes. Several signalling pathways are consistent with the observed phenotype: proliferation and apoptosis, a focal adhesion pathway indicating changes in biomechanical properties of the extracellular matrix, and immune function. Some of BPA's effects are reversed by oestrogen and/or GPER inhibitors. BPA also alters the expression of epigenetic marks (EZH2, HOTAIR), which would explain the delayed effect of foetal BPA exposure. In conclusion, experimental evidence shows that pre- or postnatal BPA exposure consistently causes endocrine modifications in the mammary tissue of different animal species, disrupting stromal-epithelial interactions and ultimately increasing its susceptibility to carcinogens. An interspecies comparison highlights why and how these effects apply to humans.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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