Abstract Title:

Anti-tumor promoting effect of glycosides from Prunus persica seeds.

Abstract Source:

Biol Pharm Bull. 2003 Feb;26(2):271-3. PMID: 12576693

Abstract Author(s):

Toshiyuki Fukuda, Hideyuki Ito, Teruo Mukainaka, Harukuni Tokuda, Hoyoku Nishino, Takashi Yoshida

Abstract:

Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (beta-gentiobioside and beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and beta-D-glucoside). The anti-tumor promoting activity of these compounds was examined in both in vitro and in vivo assays. All of the compounds significantly inhibited the Epstein-Barr virus early antigen activation induced by tumor promoter. In addition, they produced a delay of two-stage carcinogenesis on mouse skin that was comparable in potency to (-)-epigallocatechin gallate from green tea. Structure-activity relationships indicated that a substituent at the benzylic position with glycosidic linkage affected the in vitro and in vivo activities with an order of enhancing potency, CN<COOH<H.

Study Type : In Vitro Study

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