Abstract Title:

In vitro antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata.

Abstract Source:

Phytother Res. 2009 Jan;23(1):126-8. PMID: 18683849

Abstract Author(s):

Virendra K Dua, Gaurav Verma, A P Dash

Article Affiliation:

National Institute of Malaria Research, Field Unit, Sector III, BHEL, Hardwar 249 403, India. vkdua51@gmail.com

Abstract:

Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania infantum. Compound TDR13011 (1,2-dihydroxy-6,8-dimethoxy-xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC50) of 4.6 microg/ml and 8 microg/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti-protozoal activity and these compounds could be chemically modified to obtain a more potent product.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiprotozoal Agents : CK(14) : AC(5)
Additional Keywords : Xanthones : CK(48) : AC(28)

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