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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Anti-inflammatory components of Chrysanthemum indicum flowers.

Abstract Source:

Bioorg Med Chem Lett. 2015 Jan 15 ;25(2):266-9. Epub 2014 Nov 27. PMID: 25497988

Abstract Author(s):

Bui Thi Thuy Luyen, Bui Huu Tai, Nguyen Phuong Thao, Ji Yun Cha, Hoon Yeon Lee, Young Mi Lee, Young Ho Kim

Article Affiliation:

Bui Thi Thuy Luyen

Abstract:

One new octulosonic acid derivative, chrysannol A (1), along with 17 known compounds (2-18), were isolated from Chrysanthemum indicum flowers. Their structures were determined from 1D NMR, 2D NMR, HR-ESI-MS spectral data, and comparisons with previous reports. The effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor alpha (TNF-α) production by RAW 264.7 cells were investigated. Compound 8 showed the highest inhibition of NO production of 46.09% at a concentration of 10.0μM. Compounds 7, 10, 11, and 16 inhibited TNF-α secretion at all concentration tested (0.4, 2.0, and 10.0μM), with inhibition values ranging from 22.27% to 33.13%. In addition, compound 8 and 9 decrease COX-2 and iNOS protein on Western blot analysis in dose dependent manner.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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