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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation.

Abstract Source:

J Exp Ther Oncol. 2012 ;10(1):1-8. PMID: 22946339

Abstract Author(s):

Yongbo Liu, Xiaohua Gao, Dorrah Deeb, Ali S Arbab, Scott A Dulchavsky, Subhash C Gautam

Article Affiliation:

Yongbo Liu

Abstract:

Xanthohumol (XN), a prenylated chalcone present in hops exhibits anti-inflammatory, antioxidant and anticancer activity. In the present study we show that XN inhibits the proliferation of mouse lymphoma cells and IL-2 induced proliferation and cell cycle progression in mouse splenic T cells. The suppression of T cell proliferation by XN was due to the inhibition of IL-2 induced Janus kinase/signal transducers and activators of transcription (Jak/STAT) and extracellular signal-regulated kinase 1 and 2 (Erk1/2) signaling pathways. XN also inhibited proliferation-related cellular proteins such as c-Myc, c-Fos and NF-kappaB and cyclin D1. Thus, understanding of IL-2 induced cell signaling pathways in normal T cells, which are constitutively turned on in T cell lymphomas may facilitate development of XN for the treatment of hematologic cancers.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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