Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

Abstract Title:

Antioxidant vitamin levels in sickle cell disorders.

Abstract Source:

Natl Med J India. 2007 Jan-Feb;20(1):11-3. PMID: 17557515

Abstract Author(s):

Debes Ray, Pradeep Deshmukh, Kalyan Goswami, Neelam Garg

Article Affiliation:

Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442102, Maharashtra.

Abstract:

BACKGROUND: Sickle cell disorder is a haemoglobinopathy prevalent in the Vidharbha region of Maharashtra, central India. With recent evidence of oxidative stress in sickle haemoglobinopathy, a possible deficiency of antioxidant vitamins was suspected.

METHODS: We measured plasma vitamin E, vitamin C and beta-carotene levels in persons with heterozygous (n=80) and homozygous sickle cell state (n=20), and suitable healthy controls for these groups (n=100 and 66, respectively) in a community-based study in the villages near our institution.

RESULTS: Subjects with heterozygous sickle cell trait had lower vitamin E levels than their respective controls (p<0.05). Subjects with homozygous sickle cell disease had lower levels of all three vitamins (p<0.05). Vitamins E and C levels showed a significant positive correlation in both forms of sickle cell disorder.

CONCLUSION: Our findings suggest that there is depletion of the antioxidant vitamins, particularly in severe forms of sickle cell disorder. A trial of administration of therapeutic doses of vitamin E in this condition is warranted.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2017 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.