Apigenin protects against ovalbumin-induced asthma. - GreenMedInfo Summary
Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene.
Int Immunopharmacol. 2009 Jul;9(7-8):918-24. Epub 2009 Apr 5. PMID: 19345747
Department of Microbiology and Immunology, Pusan National University School of Medicine, Busan 602-739, South Korea.
Apigenin, a dietary plant-flavonoid has shown anti-inflammatory and anticancer properties, however the molecular basis of this effect remains to be elucidated. Thus we elucidated to anti-allergic effect of apigenin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic airway reactions. It included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung around blood vessels and airways, airway luminal narrowing, and the development of airway hyper-responsiveness (AHR). The administration of apigenin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that apigenin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of apigenin in terms of its effects in a murine model of asthma.