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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Protective effect of apple (Ralls) polyphenol extract against aluminum-induced cognitive impairment and oxidative damage in rat.

Abstract Source:

Neurotoxicology. 2014 Dec ;45:111-20. Epub 2014 Oct 17. PMID: 25445564

Abstract Author(s):

Dai Cheng, Yu Xi, Jiankang Cao, Dongdong Cao, Yuxia Ma, Weibo Jiang

Article Affiliation:

Dai Cheng

Abstract:

Aluminum (Al) has long been implicated in the pathogenesis of Alzheimer's disease (AD). Dietary polyphenols have been strongly associated with reduced risk of AD and the other nervous diseases. We aimed to evaluate the preventive effect of the apple polyphenol extract (APE) on Al-induced biotoxicity, in order to provide a new focus on the design of strategies to prevent AD and the other human diseases related to Al overload. Control, Al-treated (171.8 mg Al kg(-1)day(-1) 10 weeks), APE+Al (Al-treatment as previously plus 200 mg kg(-1)day(-1) 10 weeks), and group of APE per se were used. Al intake caused memory impairment, significant decrease of acetylcholinesterase, CK, SOD, CAT activity and the rate of ATP synthesis, increase the Al content, the level of malondialdehyde andβ-amyloid 42. Administration of APE significantly improved memory retention, attenuated oxidative damage, acetylcholinesterase activity and Al level in Al treated rats. Furthermore, chlorogenic acid (ChA) was used for analyzing stability of polyphenols-Al(3+) complex. Log K1 was 10.51, and the moleratio of Al(3+) to ligand was 1:1. We further found that the amounts of Al increased significantly in feces of the rats gavaged with AlCl3 plus ChA compared with AlCl3. Our finding has shown APE has neuroprotective effects against Al-induced biotoxicity. Chelating with Al and disturbing its absorption could account for the neuroprotective roles of dietary polyphenols against Al toxicity.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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