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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols.

Abstract Source:

Br J Nutr. 2009 Dec;102(11):1620-8. Epub 2009 Jul 22. PMID: 19622193

Abstract Author(s):

Cinzia Castagnini, Cristina Luceri, Simona Toti, Elisabetta Bigagli, Giovanna Caderni, Angelo P Femia, Lisa Giovannelli, Maura Lodovici, Vanessa Pitozzi, Maddalena Salvadori, Luca Messerini, Rocio Martin, Erwin G Zoetendal, Stan Gaj, Lars Eijssen, Chris T Evelo, Catherine M G C Renard, Alain Baron, Piero Dolara

Abstract:

Inflammatory bowel diseases (IBD) are immunomediated ailments affecting millions of individuals. Although diet is regarded as an important factor influencing IBD, there are no accepted dietary recommendations presently available. We administered 7.6 % lyophilised apples obtained from two cultivars (Golden Delicious and Marie Ménard, low and high in polyphenols, respectively) to HLA-B27 transgenic rats which develop spontaneous IBD. After 3 months feeding, rats fed Marie Ménard apples had reduced myeloperoxidase activity (3.6 (sem 0.3) v. 2.2 (sem 0.2) U/g tissue; P<0.05) and reduced cyclo-oxygenase-2 (P<0.05) and inducible NO synthase gene expression (P<0.01) in the colon mucosa and significantly less diarrhoea (P<0.05), compared with control rats. Cell proliferation in the colon mucosa was reduced significantly by feeding Golden Delicious apples, with a borderline effect of Marie Ménard apples. Gene expression profiling of the colon mucosa, analysed using the Whole Rat Genome 4 x 44 K Agilent Arrays, revealed a down-regulation of the pathways of PG synthesis, mitogen-activated protein kinase (MAPK) signalling and TNFalpha-NF-kappaB in Marie Ménard-fed rats. In the stools ofthe animals of this group we also measured a significant reduction of bacteria of the Bacteriodes fragilis group. In conclusion, the administration of Marie Ménard apples, rich in polyphenols and used at present only in the manufacturing of cider, ameliorates colon inflammation in transgenic ratsdeveloping spontaneous intestinal inflammation, suggesting the possible use of these and other apple varieties to control inflammation in IBD patients.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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