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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Aqueous extract of Crataegus azarolus protects against DNA damage in human lymphoblast Cell K562 and enhances antioxidant activity.

Abstract Source:

Appl Biochem Biotechnol. 2014 Feb ;172(4):2266-75. Epub 2013 Dec 19. PMID: 24347159

Abstract Author(s):

Nadia Mustapha, Inès Bouhlel, Fadwa Chaabane, Imèn Mokdad Bzéouich, Kamel Ghedira, Thierry Hennebelle, Leila Chekir-Ghedira

Article Affiliation:

Nadia Mustapha

Abstract:

The present study was carried out to characterize the cellular antioxidant effect of the aqueous extract of Crataegus azarolus and its antigenotoxic potential using human myelogenous cells, K562. The antioxidant capacity of this extract was evaluated by determining its cellular antioxidant activity (CAA) in K562 cells. Also, preceding antigenotoxicity assessment, its eventual genotoxicity property was investigated by evaluating its capacity to induce the DNA degradation of treated cell nuclei. As no genotoxicity was detected at different exposure times, its ability to protect cell DNA against H2O2 oxidative effect was investigated, using the"comet assay."It appears that 800μg/mL of extract inhibited the genotoxicity induced by H2O2 with a rate of 41.30 %, after 4 h of incubation. In addition, this extract revealed a significant cellular antioxidant capacity against the reactive oxygen species in K562 cells.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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