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Abstract Title:

The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

Abstract Source:

Res Vet Sci. 2016 Jun ;106:159-64. Epub 2015 Oct 26. PMID: 27234554

Abstract Author(s):

Jie Chen, Wentao Li, Erguang Jin, Qigai He, Weidong Yan, Hanchun Yang, Shiyu Gong, Yi Guo, Shulin Fu, Xiabing Chen, Shengqiang Ye, Yunguo Qian

Article Affiliation:

Jie Chen

Abstract:

Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in traditional Chinese medicine on porcine circovirus type 2 (PCV2) in vitro and in vivo. Results showed that dosing of 15.6-62.5μg/mL ACT could significantly inhibit the PCV2 proliferation in PK-15 cells (P<0.01). Dosing of 62.5μg/mL ACT 0, 4 or 8h after challenge inoculation significantly inhibited the proliferation of 1MOI and 10MOI in PK-15 cells (P<0.01), and the inhibitory effect of ACT dosing 4h or 8h post-inoculation was greater than 0h after dosing (P<0.01). In vivo test with mice challenge against PCV2 infection demonstrated that intraperitoneal injection of 200μg/kg ACT significantly inhibited PCV2 proliferation in the lungs, spleens and inguinal lymph nodes, with an effect similar to ribavirin, demonstrating the effectiveness of ACT as an antiviral agent against PCV2 in vitro and in vivo. This compound, therefore, may have the potential to serve as a drug for protection of pigs against the infection of PCV2.

Study Type : Animal Study

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