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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Antiviral effect of arginine against herpes simplex virus type 1.

Abstract Source:

Int J Mol Med. 2009 Apr ;23(4):495-9. PMID: 19288025

Abstract Author(s):

Takeshi Naito, Hiroshi Irie, Kazuko Tsujimoto, Keiko Ikeda, Tsutomu Arakawa, A Hajime Koyama

Article Affiliation:

Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. naito@clin.med.tokushima-u.ac.jp

Abstract:

We investigated the effects of arginine on the multiplication of herpes simplex virus type 1 (HSV-1) and the potential of arginine as an antiherpetic agent. Arginine suppressed the growth of HSV-1 concentration-dependently. Inhibition of HSV-1 by arginine leveled off at 50-60 mM, although the higher concentration was not suitable as an antiviral agent due to cytotoxicity. 'Time of addition' experiments revealed that arginine was particularly effective when added within 6 h post-infection (h p.i.), suggesting that the reagent sensitive step is in the early stages of the infection. A one-step growth curve of HSV-1 in the presence of 30 mM arginine revealed that: i) the latent period was significantly extended, ii) the rate of formation of progeny infectious virus decreased and iii) the final yield of progeny virus decreased to 1%. The addition of arginine at 8 h p.i., after the completion of viral DNA replication in the virus multiplication, allowed the normal formation of progeny virus in the subsequent 4 h, confirming that arginine does not directly interfere with the formation of progeny infectious virus. In addition, arginine also inhibits several RNA viruses.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(938) : AC(433)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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