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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Artificial light at night: melatonin as a mediator between the environment and epigenome.

Abstract Source:

Philos Trans R Soc Lond B Biol Sci. 2015 May 5 ;370(1667). PMID: 25780234

Abstract Author(s):

Abraham Haim, Abed E Zubidat

Article Affiliation:

Abraham Haim

Abstract:

The adverse effects of excessive use of artificial light at night (ALAN) are becoming increasingly evident and associated with several health problems including cancer. Results of epidemiological studies revealed that the increase in breast cancer incidents co-distribute with ALAN worldwide. There is compiling evidence that suggests that melatonin suppression is linked to ALAN-induced cancer risks, but the specific genetic mechanism linking environmental exposure and the development of disease is not well known. Here we propose a possible genetic link between environmental exposure and tumorigenesis processes. We discuss evidence related to the relationship between epigenetic remodelling and oncogene expression. In breast cancer, enhanced global hypomethylation is expected in oncogenes, whereas in tumour suppressor genes local hypermethylation is recognized in the promoter CpG chains. A putative mechanism of action involving epigenetic modifications mediated by pineal melatonin is discussed in relation to cancer prevalence. Taking into account that ALAN-induced epigenetic modifications are reversible, early detection of cancer development is of great significance in the treatment of the disease. Therefore, new biomarkers for circadian disruption need to be developed to prevent ALAN damage.

Study Type : Review
Additional Links
Anti Therapeutic Actions : Artifical Lighting : CK(12) : AC(3)

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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