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Abstract Title:

Ascorbic acid supplementation diminishes microparticle elevations and neutrophil activation following SCUBA diving.

Abstract Source:

Am J Physiol Regul Integr Comp Physiol. 2015 Aug 15 ;309(4):R338-44. Epub 2015 Jun 17. PMID: 26084697

Abstract Author(s):

Ming Yang, Otto F Barak, Zeljko Dujic, Dennis Madden, Veena M Bhopale, Jasjeet Bhullar, Stephen R Thom

Article Affiliation:

Ming Yang

Abstract:

Predicated on evidence that diving-related microparticle generation is an oxidative stress response, this study investigated the role that oxygen plays in augmenting production of annexin V-positive microparticles associated with open-water SCUBA diving and whether elevations can be abrogated by ascorbic acid. Following a cross-over study design, 14 male subjects ingested placebo and 2-3 wk later ascorbic acid (2 g) daily for 6 days prior to performing either a 47-min dive to 18 m of sea water while breathing air (∼222 kPa N2/59 kPa O2) or breathing a mixture of 60% O2/balance N2 from a tight-fitting face mask at atmospheric pressure for 47 min (∼40 kPa N2/59 kPa O2). Within 30 min after the 18-m dive in the placebo group, neutrophil activation, and platelet-neutrophil interactions occurred, and the totalnumber of microparticles, as well as subgroups bearing CD66b, CD41, CD31, CD142 proteins or nitrotyrosine, increased approximately twofold. No significant elevations occurred among divers after ingesting ascorbic acid, nor were elevations identified in either group after breathing 60% O2. Ascorbicacid had no significant effect on post-dive intravascular bubble production quantified by transthoracic echocardiography. We conclude that high-pressure nitrogen plays a key role in neutrophil and microparticle-associated changes with diving and that responses can be abrogated by dietary ascorbic acid supplementation.

Study Type : Human Study

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