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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway.

Abstract Source:

Int J Biol Sci. 2016 ;12(7):861-71. Epub 2016 May 25. PMID: 27313499

Abstract Author(s):

Zhen-Guo Ma, Jia Dai, Wen-Ying Wei, Wen-Bin Zhang, Si-Chi Xu, Hai-Han Liao, Zheng Yang, Qi-Zhu Tang

Article Affiliation:

Zhen-Guo Ma

Abstract:

BACKGROUND: AMPactivated protein kinaseα (AMPKα) is closely involved in the process of cardiac hypertrophy. Asiatic acid (AA), a pentacyclic triterpene, was found to activate AMPKα in our preliminary experiment. However, its effects on the development of cardiac hypertrophy remain unclear. The present study was to determine whether AAcould protect against cardiac hypertrophy.

METHODS: Mice subjected to aortic banding were orally given AA (10 or 30mg/kg) for 7 weeks. In the inhibitory experiment, Compound C was intraperitoneally injected for 3 weeks after surgery.

RESULTS: Our results showed that AA markedly inhibited hypertrophic responses induced by pressure overload or angiotensin II. AA also suppressed cardiac fibrosis in vivo and accumulation of collagen in vitro. The protective effects of AA were mediated by activation of AMPKα and inhibition of the mammalian target of rapamycin (mTOR) pathway and extracellular signal-regulated kinase (ERK) in vivo and in vitro. However, AA lost the protective effects after AMPKα inhibition or gene deficiency.

CONCLUSIONS: AA protects against cardiac hypertrophy by activating AMPKα, and has the potential to be used for the treatment of heart failure.

Study Type : Animal Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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