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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Neurophysiological symptoms and aspartame: What is the connection?

Abstract Source:

Nutr Neurosci. 2017 Feb 15:1-11. Epub 2017 Feb 15. PMID: 28198207

Abstract Author(s):

Arbind Kumar Choudhary, Yeong Yeh Lee

Article Affiliation:

Arbind Kumar Choudhary

Abstract:

Aspartame (α-aspartyl-l-phenylalanine-o-methyl ester), an artificial sweetener, has been linked to behavioral and cognitive problems. Possible neurophysiological symptoms include learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia. The consumption of aspartame,unlike dietary protein, can elevate the levels of phenylalanine and aspartic acid in the brain. These compounds can inhibit the synthesis and release of neurotransmitters, dopamine, norepinephrine, and serotonin, which are known regulators of neurophysiological activity. Aspartame acts as a chemicalstressor by elevating plasma cortisol levels and causing the production of excess free radicals. High cortisol levels and excess free radicals may increase the brains vulnerability to oxidative stress which may have adverse effects on neurobehavioral health. We reviewed studies linking neurophysiological symptoms to aspartame usage and conclude that aspartame may be responsible for adverse neurobehavioral health outcomes. Aspartame consumption needs to be approached with caution due to the possible effects on neurobehavioral health. Whether aspartame and its metabolites are safe for general consumption is still debatable due to a lack of consistent data. More research evaluating the neurobehavioral effects of aspartame are required.

Study Type : Review
Additional Links
Problem Substances : Aspartame : CK(135) : AC(47)
Adverse Pharmacological Actions : Neurotoxic : CK(1396) : AC(289)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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