Aspartame is a multipotential carcinogenic agent even at doses well below the current acceptable daily intake. - GreenMedInfo Summary

Abstract Title:

First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats.

Abstract Source:

Environ Health Perspect. 2006 Mar;114(3):379-85. PMID: 16507461

Abstract Author(s):

Morando Soffritti, Fiorella Belpoggi, Davide Degli Esposti, Luca Lambertini, Eva Tibaldi, Anna Rigano

Article Affiliation:

Cesare Maltoni Cancer Research Center, European Ramazzini Foundation of Oncology and Environmental Sciences, Bologna, Italy. crcfr@ramazzini.it

Abstract:

The Cesare Maltoni Cancer Research Center of the European Ramazzini Foundation has conducted a long-term bioassay on aspartame (APM), a widely used artificial sweetener. APM was administered with feed to 8-week-old Sprague-Dawley rats (100-150/sex/group), at concentrations of 100,000, 50,000, 10,000, 2,000, 400, 80, or 0 ppm. The treatment lasted until natural death, at which time all deceased animals underwent complete necropsy. Histopathologic evaluation of all pathologic lesions and of all organs and tissues collected was routinely performed on each animal of all experimental groups. The results of the study show for the first time that APM, in our experimental conditions, causes a) an increased incidence of malignant-tumor-bearing animals with a positive significant trend in males (p

Article Published Date : Mar 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Leukemia : CK(670) : AC(258), Lymphoma : CK(209) : AC(69)
Problem Substances : Aspartame : CK(103) : AC(30)

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