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Abstract Title:

Effects of astaxanthin on oxidative stress induced by Cu(2+) in prostate cells.

Abstract Source:

J Zhejiang Univ Sci B. 2017 Feb.;18(2):161-171. PMID: 28124844

Abstract Author(s):

Hong-Zhou Meng, Xiao-Feng Ni, Hai-Ning Yu, Shan-Shan Wang, Sheng-Rong Shen

Article Affiliation:

Hong-Zhou Meng

Abstract:

Astaxanthin (AST), a carotenoid molecule extensively found in marine organisms and increasingly used as a dietary supplement, has been reported to have beneficial effects against oxidative stress. In the current paper, the effects of AST on viability of prostate cells were investigated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay; cell apoptosis and intracellular reactive oxygen species (ROS) levels were determined by flow cytometry; the mitochondrial membrane potential (MMP) was measured by fluorospectrophotometer; and activities of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were evaluated by a detection kit. The results show that copper ion (Cu(2+)) induced apoptosis, along with the accumulation of intracellular ROS and MDA, in both prostate cell lines (RWPE-1 and PC-3). AST treatments could decrease the MDA levels, increase MMP, and keep ROS stable in RWPE-1 cell line. An addition of AST decreased the SOD, GSH-Px, and CAT activities in PC-3 cell line treated with Cu(2+), but had a contrary reaction in RWPE-1 cell lines. In conclusion, AST could contribute to protecting RWPE-1 cells against Cu(2+)-induced injuries but could cause damage to the antioxidant enzyme system in PC-3 cells.

Study Type : In Vitro Study

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