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Abstract Title:

Effects of atorvastatin on heart mitochondrial function and coenzyme Q content in the experiment.

Abstract Source:

Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983

Abstract Author(s):

J Kucharska, O Ulicna, A Gvozdjakova, O Vancova, I Waczulikova, P Bozek, V Bada

Article Affiliation:

Pharmacobiochemical Laboratory of Third Department of lnternal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia. jarmila.kucharska@fmed.uniba.sk

Abstract:

We focused on determination of whether atorvastatin: 1) reduces CoQ content, 2) impairs mitochondrial function and 3) induces dose-dependent changes. Although the high dose of atorvastatin exerted a beneficial effect on the lipid peroxidation in plasma, coenzyme Q content was reduced and heart mitochondrial function was impaired. Physicians should be aware when prescribing statins mainly in higher doses to the patients with co-existing proved or supposed CoQ10 deficiency resulting from age-related decline, and metabolic or mitochondrial diseases (Ref. 3).

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Sayer Ji
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