Autoimmune hepatitis associated with atorvastatin use has been reported. - GreenMedInfo Summary

Abstract Title:

Autoimmune hepatitis revealed by atorvastatin.

Abstract Source:

Eur J Gastroenterol Hepatol. 2003 Aug ;15(8):921-4. PMID: 12867804

Abstract Author(s):

Nicoletta Pelli, Maurizio Setti, Paola Ceppa, Carlo Toncini, Francesco Indiveri

Article Affiliation:

Department of Internal Medicine, Clinical Immunology Unit, University of Genoa, Genoa, Italy.

Abstract:

Cases of acute hepatitis induced by statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have been reported. A 65-year-old woman was admitted to our hospital because of fatigue, jaundice and altered liver function tests while on treatment with atorvastatin. On the basis of clinical, serological and histological findings, a score leading to a diagnosis of autoimmune hepatitis was reached. We suggest that atorvastatin may have revealed an underlying autoimmune hepatitis.

Article Published Date : Aug 01, 2003
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis: Autoimmune : CK(41) : AC(8), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

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