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Abstract Title:

Chemomodulatory effects of Aegle marmelos against DMBA-induced skin tumorigenesis in Swiss albino mice.

Abstract Source:

Asian Pac J Cancer Prev. 2010;11(5):1311-4. PMID: 21198283

Abstract Author(s):

Annapurna Agrawal, Preeti Verma, P K Goyal

Article Affiliation:

Department of Zoology, University of Rajasthan, India E-mail: pkgoyal2002@gmail.com.

Abstract:

Aegle marmelos is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. In the present study, cancer chemopreventive properties were evaluated on 7, 12-dimethylbenz (a) anthracene (DMBA) induced skin papillomagenesis in Swiss albino mice. A single topical application of DMBA, followed 2 weeks later by repeated application of croton oil till the end of the experiment ( i.e. 16 weeks) caused a 100% tumor incidence. In contrast, mice treated with the AME (50 mg/kg b. wt./animal/day) in the peri-initiational phase (i.e. 7 days before and 7 days after DMBA application; Group IV) and post-initiational phase (from the day of croton oil treatment till the end of the experiment; Group V), exhibited a significant reduction to 70 and 50% respectively. The cumulative number of papillomas after 16 weeks was 67 in the control group, but 26 and 23 in the animals treated with AME at peri-initiational and post-initiational stages, respectively. The tumor burden and tumor yield were significantly decreased (Group IV-3.7, 2.6; Group V- 4.6, 2.3) as compared to carcinogen treated control group (6.7, 6.7). The present study demonstrates the chemopreventive potential of Aegle marmelos fruit extract on DMBA induced skin tumorigenesis in mice.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Chemopreventive : CK(2835) : AC(787)

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Sayer Ji
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