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Abstract Title:

Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss.

Abstract Source:

Neurosci Lett. 2010 Jan 29;469(3):298-302. Epub 2009 Dec 11. PMID: 20004700

Abstract Author(s):

Tong Ho Kang, Bin Na Hong, Channy Park, Se Young Kim, Raekil Park

Article Affiliation:

College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, Republic of Korea.

Abstract:

Noise-induced hearing loss (NIHL) has been thought to primarily involve damage to the sensory hair cells of the cochlea via mechanical and metabolic mechanisms. This study examined the effects of baicalin, baicalein, and Scutellaria baicalensis (SB) extract against NIHL in a mouse model. Mice received oral treatment with SB, baicalin, baicalein beginning 30 min prior to noise exposure and continuing once daily throughout the study. Hearing threshold shift was assessed by auditory brain stem responses for 35 days following noise exposure. Central auditory function was evaluated by auditory middle latency responses. Cochlear function was determined based on transient evoked otoacoustic emissions. SB significantly reduced threshold shift, central auditory function damage, and cochlear function deficits, suggesting that SB may protect auditory function in NIHL and that the active constituent may be a flavonoid, baicalein.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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