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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Effects of Musa sapientum stem extract on experimental models of anxiety.

Abstract Source:

Avicenna J Phytomed. 2017 Nov-Dec;7(6):495-501. PMID: 29299432

Abstract Author(s):

Aditya Jielella Reddy, Ashok Kumar Dubey, Shailendra Handu, Manocha Sachin, Pramod Kumari Mediratta, Qazi Ahmed Mushtaq

Article Affiliation:

Aditya Jielella Reddy

Abstract:

Objective: The Musa sapientum (banana) plant extract has shown antioxidant activity in previous studies. Oxidative stress is one of the important factors implicated in the pathogenesis of anxiety disorders. The present study aimed to evaluate the anxiolytic activity of aqueous extract of M. sapientum stem (MSSE) in experimental models in mice.

Material and Methods: Elevated Plus Maze method and locomotor monitoring by photoactometer were used. Animals were divided into five different groups (n=6/group). The vehicle, standard and the experimental groups were given distilled water (10 ml/kg), diazepam (1 mg /kg intraperitoneally) and incremental doses of 25, 50 and 100 mg/kg of MSSE, respectively, prior to the experiment. The standard group received diazepam.

Results: The number of open arm entries and the duration of time spent in the open arms in the MSSE-treated groups increased significantly in a dose-dependent manner as compared to that of control group. The duration of time spent in closed arms in the MSSE-treated groups decreased significantly in a dose-dependent manner as compared to that of the control group. MSSE also decreased the locomotor activity significantly at all three test doses.

Conclusion: The results of this study suggest an anxiolytic activity for MSSE, which make it a potential natural compound for treatment of anxiety disorders.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anti-Anxiety Agents : CK(356) : AC(59)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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