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Abstract Title:

The hypoglycemic effects of guava leaf (Psidium guajava L.) extract are associated with improving endothelial dysfunction in mice with diet-induced obesity.

Abstract Source:

Food Res Int. 2017 Jun ;96:64-71. Epub 2017 Mar 11. PMID: 28528109

Abstract Author(s):

Elixabet Díaz-de-Cerio, Alba Rodríguez-Nogales, Francesca Algieri, Miguel Romero, Vito Verardo, Antonio Segura-Carretero, Juan Duarte, Julio Galvez

Article Affiliation:

Elixabet Díaz-de-Cerio

Abstract:

Obesity is associated with a low-grade inflammatory status that affects vascular function. Previous studies have reported the beneficial effects of Psidium guajava L. (guava) on diabetes. Here we evaluate the how guava leaf extract at the dose of 5 mg/kg, affects vascular dysfunction in obese mice fed a high-fat diet for 7 weeks. Extract intake did not alter weight over time, although it reduced glycemia and insulin resistance, improving the serum lipid profile in obese mice. Additionally, guava leaf extract reversed the endothelial dysfunction found in obese mice in terms of endothelium- and NO (nitric oxide)-dependent vasodilatation induced by acetylcholine in aortic rings. In conclusion, the beneficial effects of guava leaf extract in obese mice were associated with improved vascular functions altered by obesity, probably due to its phenolic content.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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