Benzene exposure is associated with hypertension, possibly due to disturbance of nitric oxide process. - GreenMedInfo Summary

Abstract Title:

Benzene exposure and hypertension: an observation.

Abstract Source:

Cardiovasc J Afr. 2007 Jul-Aug;18(4):264-5. PMID: 17940673

Abstract Author(s):

Viroj Wiwanitkit

Article Affiliation:

Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Abstract:

Pollutants such as benzene are of particular concern since recent research has indicated that exposure to benzene can result in chronic toxicity. However, there are limited data on the effects of benzene exposure on blood pressure. To continue with a previous study, the aim was to determine the degree of exposure to benzene using the classic biomarker, urine phenol, and its correlation with hypertension. From the results of this study, the rate of hypertension in the group with high exposure to benzene (100%) was significantly higher than that in the group with less exposure (49%). A possible mechanism of benzene-induced hypertension could be disturbance of the nitric oxide process, subsequently leading to hypertension. However, the actual mechanism causing hypertension in subjects exposed to benzene requires further study.

Article Published Date : Jul 01, 2007
Study Type : Human Study
Additional Links
Diseases : Endothelial Dysfunction : CK(897) : AC(173), Hypertension : CK(2783) : AC(271)
Problem Substances : Benzene : CK(130) : AC(22)
Adverse Pharmacological Actions : Hypertensive : CK(68) : AC(9)

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