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Abstract Title:

Effects of berberine on acquisition and reinstatement of morphine-induced conditioned place preference in mice.

Abstract Source:

Avicenna J Phytomed. 2016 Mar-Apr;6(2):198-204. PMID: 27222833

Abstract Author(s):

Faezeh Vahdati Hassani, Mahmoud Hashemzaei, Edris Akbari, Mohsen Imenshahidi, Hossein Hosseinzadeh

Article Affiliation:

Faezeh Vahdati Hassani

Abstract:

OBJECTIVE: It has been shown that berberine, a major component of Berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (Da) and N-methyl-D-aspartate (NMDA) contributing to rewarding and reinforcing effects of morphine. Drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. In the present study, we investigated the alleviating effects of berberine on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice.

MATERIALS AND METHODS: In male NMRI mice, the acquisition of CPP was established by 40 mg/kg of morphine sulphate injection and extinguished after the extinction training and reinstated by a 10 mg/kg injection of morphine. The effects of different doses of berberine (5, 10, and 20 mg/kg) on the acquisition and reinstatement induced by morphine were evaluated in a conditioned place preference test.

RESULTS: The results showed that intraperitoneal administration of berberine (5, 10, and 20 mg/kg) did not induce conditioned appetitive or aversive effects. Injection of berberine (10 and 20 mg/kg) 2 h before the morphine administration reduced acquisition of morphine-induced CPP. In addition, same doses of berberine significantly prevented the reinstatement of morphine-induced CPP.

CONCLUSION: These results suggest that berberine can reduce the acquisition and reinstatement of morphine-induced conditioned place preference and may be useful in treatment of morphine addiction.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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